{"id":"https://openalex.org/W2015540775","doi":"https://doi.org/10.1038/sj.cgt.7700972","title":"Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells","display_name":"Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells","publication_year":2006,"publication_date":"2006-06-16","ids":{"openalex":"https://openalex.org/W2015540775","doi":"https://doi.org/10.1038/sj.cgt.7700972","mag":"2015540775","pmid":"https://pubmed.ncbi.nlm.nih.gov/16783343"},"language":"en","primary_location":{"id":"doi:10.1038/sj.cgt.7700972","doi":"https://doi.org/10.1038/sj.cgt.7700972","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cgt.7700972","pdf_url":null,"source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044655474","display_name":"Dora Bocangel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Bocangel","raw_affiliation_strings":["Introgen Therapeutics Inc., Houston, TX 77030, USA","Introgen Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Introgen Therapeutics Inc., Houston, TX 77030, USA","institution_ids":[]},{"raw_affiliation_string":"Introgen Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037860420","display_name":"Mingzhong Zheng","orcid":"https://orcid.org/0009-0007-5090-7398","observed_orcids":["https://orcid.org/0009-0007-5090-7398"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Zheng","raw_affiliation_strings":["Introgen Therapeutics Inc., Houston, TX, USA","Introgen Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Introgen Therapeutics Inc., Houston, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Introgen Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109921549","display_name":"Abner M. Mhashilkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Mhashilkar","raw_affiliation_strings":["Introgen Therapeutics Inc., Houston, TX, USA","Introgen Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Introgen Therapeutics Inc., Houston, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Introgen Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064834869","display_name":"Y. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Liu","raw_affiliation_strings":["Departments of Surgical Oncology and Tumor Biology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgical Oncology and Tumor Biology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068736204","display_name":"Rajagopal Ramesh","orcid":"https://orcid.org/0000-0002-7658-5338","observed_orcids":["https://orcid.org/0000-0002-7658-5338"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Ramesh","raw_affiliation_strings":["Departments of Thoracic and Cardiovascular Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Thoracic and Cardiovascular Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017411324","display_name":"Kelly K. Hunt","orcid":"https://orcid.org/0000-0001-9156-8723","observed_orcids":["https://orcid.org/0000-0001-9156-8723"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K K Hunt","raw_affiliation_strings":["Departments of Surgical Oncology and Tumor Biology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA","Cancer Center Support Grant (CCSG) Programs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgical Oncology and Tumor Biology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Cancer Center Support Grant (CCSG) Programs","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112369989","display_name":"Sunil Chada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S Chada","raw_affiliation_strings":["Introgen Therapeutics Inc., Houston, TX, USA","Introgen Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Introgen Therapeutics Inc., Houston, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Introgen Therapeutics, Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112369989"],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.0399,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76298117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"10","first_page":"958","last_page":"968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.13779999315738678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mda-7","display_name":"MDA-7","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9269999861717224},{"id":"https://openalex.org/keywords/her-2-neu-overexpression","display_name":"HER-2/neu overexpression","score":0.8640000224113464},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.7960000038146973},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/beta-catenin-nuclear-translocation","display_name":"\u03b2-catenin nuclear translocation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.656000018119812},{"id":"https://openalex.org/keywords/isobologram-analysis","display_name":"isobolographic analysis","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6517618894577026},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.6002535820007324},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.49583253264427185},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4544638991355896},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42168277502059937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39783012866973877},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35747072100639343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27113276720046997},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.22271302342414856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1583053171634674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099180","descriptor_name":"Interleukin-24","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.cgt.7700972","doi":"https://doi.org/10.1038/sj.cgt.7700972","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cgt.7700972","pdf_url":null,"source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},{"id":"pmid:16783343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16783343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1501037232","https://openalex.org/W1531524380","https://openalex.org/W1572047430","https://openalex.org/W1585683447","https://openalex.org/W1823204508","https://openalex.org/W1933350662","https://openalex.org/W1973046279","https://openalex.org/W1983366532","https://openalex.org/W1989513172","https://openalex.org/W1990879645","https://openalex.org/W2001401716","https://openalex.org/W2010579356","https://openalex.org/W2019072035","https://openalex.org/W2030099710","https://openalex.org/W2038173563","https://openalex.org/W2054817881","https://openalex.org/W2071479324","https://openalex.org/W2072553587","https://openalex.org/W2082968947","https://openalex.org/W2093295719","https://openalex.org/W2095156669","https://openalex.org/W2100375606","https://openalex.org/W2104337757","https://openalex.org/W2114974083","https://openalex.org/W2115420461","https://openalex.org/W2118299100","https://openalex.org/W2125807001","https://openalex.org/W2130934175","https://openalex.org/W2135615816","https://openalex.org/W2141393790","https://openalex.org/W2143759076","https://openalex.org/W2151790613","https://openalex.org/W2159459001","https://openalex.org/W2170815810","https://openalex.org/W2234798757","https://openalex.org/W2238881100","https://openalex.org/W2321501275","https://openalex.org/W2323327334"],"related_works":["https://openalex.org/W2010579356","https://openalex.org/W1562417738","https://openalex.org/W1966523626","https://openalex.org/W1521892392","https://openalex.org/W2017046500","https://openalex.org/W2381898192","https://openalex.org/W2088859629","https://openalex.org/W2039578335","https://openalex.org/W1585683447","https://openalex.org/W3212599718"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
