{"id":"https://openalex.org/W2015515436","doi":"https://doi.org/10.1080/03009740410007014","title":"Immunomodulatory function of the 5\u2010HT3receptor antagonist tropisetron","display_name":"Immunomodulatory function of the 5\u2010HT3receptor antagonist tropisetron","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2015515436","doi":"https://doi.org/10.1080/03009740410007014","mag":"2015515436","pmid":"https://pubmed.ncbi.nlm.nih.gov/15515411"},"language":"en","primary_location":{"id":"doi:10.1080/03009740410007014","doi":"https://doi.org/10.1080/03009740410007014","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03009740410007014","pdf_url":null,"source":{"id":"https://openalex.org/S42124886","display_name":"Scandinavian Journal of Rheumatology","issn_l":"0300-9742","issn":["0300-9742","1502-7732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110106578","display_name":"EM Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"EM Schneider","raw_affiliation_strings":["Section of Experimental Anesthesiology, University Clinic Ulm, Ulm","Section of Experimental Anesthesiology, University Clinic Ulm, Ulm, Germany. marion.schneider@medizin.uni-ulm.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Experimental Anesthesiology, University Clinic Ulm, Ulm","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Section of Experimental Anesthesiology, University Clinic Ulm, Ulm, Germany. marion.schneider@medizin.uni-ulm.de","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034606486","display_name":"Xiu\u2010Juan Ma","orcid":"https://orcid.org/0000-0001-6832-0471","observed_orcids":["https://orcid.org/0000-0001-6832-0471"]},"institutions":[{"id":"https://openalex.org/I4210108154","display_name":"Hochrhein Institut f\u00fcr Rehabilitationsforschung","ror":"https://ror.org/01jy3gh06","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108154"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"X Ma","raw_affiliation_strings":["Hochrhein Institute, Bad S\u00e4ckingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hochrhein Institute, Bad S\u00e4ckingen","institution_ids":["https://openalex.org/I4210108154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110679157","display_name":"Th. Stratz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Stratz","raw_affiliation_strings":["Department of Pain Therapy, Ulm University Hospital, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pain Therapy, Ulm University Hospital, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W M\u00fcller","raw_affiliation_strings":["Section of Experimental Anesthesiology, University Clinic Ulm, Ulm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Experimental Anesthesiology, University Clinic Ulm, Ulm","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I Lorenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108154","display_name":"Hochrhein Institut f\u00fcr Rehabilitationsforschung","ror":"https://ror.org/01jy3gh06","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108154"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I Lorenz","raw_affiliation_strings":["Hochrhein Institute, Bad S\u00e4ckingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hochrhein Institute, Bad S\u00e4ckingen","institution_ids":["https://openalex.org/I4210108154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111659000","display_name":"WD Seeling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"WD Seeling","raw_affiliation_strings":["Department of Pain Therapy, Ulm University Hospital, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pain Therapy, Ulm University Hospital, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110106578"],"corresponding_institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"],"apc_list":null,"apc_paid":null,"fwci":0.1785,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.55112865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"sup119","first_page":"34","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tropisetron","display_name":"tropisetron","score":0.9629999995231628},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.9190000295639038},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/fibromyalgia","display_name":"fibromyalgia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha-stimulation","display_name":"TNF-alpha stimulation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/monocyte-count","display_name":"monocyte count","score":0.5920000076293945},{"id":"https://openalex.org/keywords/mip-1beta","display_name":"MIP-1\u03b2","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8366435766220093},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6390138864517212},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6353074908256531},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5447564721107483},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5392844080924988},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5117716193199158},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.503999650478363},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.5010950565338135},{"id":"https://openalex.org/C2778144076","wikidata":"https://www.wikidata.org/wiki/Q29428","display_name":"Tropisetron","level":4,"score":0.49730852246284485},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.44946861267089844},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4333036541938782},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.42327573895454407},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42125117778778076},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38274848461151123},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.35525768995285034},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3123331665992737},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3004971742630005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07557305693626404},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077526","descriptor_name":"Tropisetron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005356","descriptor_name":"Fibromyalgia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005356","descriptor_name":"Fibromyalgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/03009740410007014","doi":"https://doi.org/10.1080/03009740410007014","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03009740410007014","pdf_url":null,"source":{"id":"https://openalex.org/S42124886","display_name":"Scandinavian Journal of Rheumatology","issn_l":"0300-9742","issn":["0300-9742","1502-7732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Rheumatology","raw_type":"journal-article"},{"id":"pmid:15515411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15515411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of rheumatology. Supplement","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1563910358","https://openalex.org/W1750185880","https://openalex.org/W2034858091","https://openalex.org/W2069368135","https://openalex.org/W2072866578","https://openalex.org/W2168251051","https://openalex.org/W2171487934","https://openalex.org/W2317838482","https://openalex.org/W2412418820"],"related_works":["https://openalex.org/W2042937727","https://openalex.org/W2097731248","https://openalex.org/W2089894881","https://openalex.org/W2130326256","https://openalex.org/W1996073484","https://openalex.org/W2066365643","https://openalex.org/W2171487934","https://openalex.org/W2081817123","https://openalex.org/W2061376330","https://openalex.org/W177412553"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"characterize":[2],"the":[3,41,156],"immune":[4],"modulatory":[5],"effects":[6,83],"of":[7,50,69],"5-HT3":[8,132],"receptor":[9,133],"antagonist":[10],"treatment":[11],"in":[12,81,88,97,105,116,143,150],"patients":[13,52,64,119,125],"with":[14,34],"fibromyalgia,":[15],"autoimmune":[16],"disorders,":[17],"and":[18,28,57,77,101,153],"chronic":[19],"pain.":[20],"METHODS:":[21],"Multiplex-assisted":[22],"cytokine":[23],"measurements":[24],"were":[25],"performed":[26],"before":[27],"during":[29],"treatment.":[30],"Whole":[31],"blood":[32],"stimulation":[33,112],"TNF-alpha":[35,111],"was":[36,113],"carried":[37],"out":[38],"to":[39,55,120,160],"determine":[40],"proinflammatory":[42],"response":[43,159],"induced":[44],"by":[45],"exogenous":[46,161],"TNF-alpha.":[47,162],"RESULTS:":[48],"Five":[49],"nine":[51],"clinically":[53],"responded":[54],"treatment,":[56],"two":[58,98,106],"had":[59,65],"a":[60,93,121,127],"moderate":[61,151],"response.":[62,130],"All":[63],"significantly":[66],"elevated":[67],"levels":[68],"T-H1":[70,103,141],"cytokines":[71,104,142],"more":[72],"prominent":[73],"than":[74],"TNF-alpha,":[75],"IL-1beta,":[76],"IL-6.":[78],"Treatment":[79],"resulted":[80],"transient":[82],"on":[84],"peripheral":[85],"monocyte":[86,137],"counts":[87],"all":[89],"but":[90],"one":[91],"patient,":[92],"plasma":[94],"IL-1beta":[95],"increase":[96],"responder":[99,107,118],"patients,":[100],"decreased":[102],"patients.":[108],"Ex":[109],"vivo":[110,158],"transiently":[114,135,154],"reconstituted":[115],"three":[117],"significant":[122],"level.":[123],"Three":[124],"showed":[126],"marginal":[128],"reconstitutive":[129],"CONCLUSION:":[131],"blockade":[134],"affects":[136,155],"tissue":[138],"infiltration,":[139],"modulates":[140],"clinical":[144],"responders":[145],"as":[146,148],"well":[147],"MIP-1beta":[149],"responders,":[152],"ex":[157]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
