{"id":"https://openalex.org/W2015508594","doi":"https://doi.org/10.1371/journal.pone.0048167","title":"Efficient Detection of Mediterranean \u03b2-Thalassemia Mutations by Multiplex Single-Nucleotide Primer Extension","display_name":"Efficient Detection of Mediterranean \u03b2-Thalassemia Mutations by Multiplex Single-Nucleotide Primer Extension","publication_year":2012,"publication_date":"2012-10-26","ids":{"openalex":"https://openalex.org/W2015508594","doi":"https://doi.org/10.1371/journal.pone.0048167","mag":"2015508594","pmid":"https://pubmed.ncbi.nlm.nih.gov/23110203","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3482202"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0048167","doi":"https://doi.org/10.1371/journal.pone.0048167","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048167","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048167&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048167&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015898693","display_name":"Biljana Atanasovska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174143326","display_name":"Macedonian Academy of Sciences and Arts","ror":"https://ror.org/003jsdw96","country_code":"MK","type":"education","lineage":["https://openalex.org/I174143326"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Biljana Atanasovska","raw_affiliation_strings":["Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia","institution_ids":["https://openalex.org/I174143326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111009507","display_name":"Gjorgji Bozhinovski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174143326","display_name":"Macedonian Academy of Sciences and Arts","ror":"https://ror.org/003jsdw96","country_code":"MK","type":"education","lineage":["https://openalex.org/I174143326"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Georgi Bozhinovski","raw_affiliation_strings":["Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia","institution_ids":["https://openalex.org/I174143326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037585954","display_name":"Dijana Plaseska\u2010Karanfilska","orcid":"https://orcid.org/0000-0001-8877-2416","observed_orcids":["https://orcid.org/0000-0001-8877-2416"]},"institutions":[{"id":"https://openalex.org/I174143326","display_name":"Macedonian Academy of Sciences and Arts","ror":"https://ror.org/003jsdw96","country_code":"MK","type":"education","lineage":["https://openalex.org/I174143326"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Dijana Plaseska-Karanfilska","raw_affiliation_strings":["Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia","institution_ids":["https://openalex.org/I174143326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105887426","display_name":"Lyubomira Chakalova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174143326","display_name":"Macedonian Academy of Sciences and Arts","ror":"https://ror.org/003jsdw96","country_code":"MK","type":"education","lineage":["https://openalex.org/I174143326"]},{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210096874","display_name":"Institute of Molecular Biology","ror":"https://ror.org/00t7c6f62","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210096874"]}],"countries":["BG","MK"],"is_corresponding":true,"raw_author_name":"Lyubomira Chakalova","raw_affiliation_strings":["Department of Molecular Biology of the Cell Cycle, Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria","Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology of the Cell Cycle, Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210096874"]},{"raw_affiliation_string":"Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, Former Yugoslav Republic of Macedonia","institution_ids":["https://openalex.org/I174143326"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5105887426"],"corresponding_institution_ids":["https://openalex.org/I174143326","https://openalex.org/I24768866","https://openalex.org/I4210096874"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.7211,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67699591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"7","issue":"10","first_page":"e48167","last_page":"e48167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hemoglobinopathy-diagnosis","display_name":"hemoglobinopathy diagnosis","score":0.6629999876022339},{"id":"https://openalex.org/keywords/hemoglobin-s","display_name":"hemoglobin S","score":0.6140000224113464},{"id":"https://openalex.org/keywords/one-tube-assay","display_name":"one-tube assay","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7059503793716431},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.7020313739776611},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6636255383491516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5965954065322876},{"id":"https://openalex.org/C194857396","wikidata":"https://www.wikidata.org/wiki/Q382878","display_name":"Primer extension","level":4,"score":0.5185583233833313},{"id":"https://openalex.org/C2777940137","wikidata":"https://www.wikidata.org/wiki/Q3616632","display_name":"Beta thalassemia","level":3,"score":0.46298161149024963},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4613803029060364},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.4519363343715668},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.43314534425735474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18481451272964478},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.16919732093811035},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.15963506698608398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.05487993359565735}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060885","descriptor_name":"Multiplex Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0048167","doi":"https://doi.org/10.1371/journal.pone.0048167","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048167","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048167&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2475479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3482202","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23110203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23110203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3482202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3482202/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.802.6978","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.802.6978","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/67/4e/pone.0048167.PMC3482202.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9afff0858d054e03bc420bb2952eb373","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9afff0858d054e03bc420bb2952eb373","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 10, p e48167 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1083672","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Efficient_Detection_of_Mediterranean_946_Thalassemia_Mutations_by_Multiplex_Single_Nucleotide_Primer_Extension_/1083672","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0048167","doi":"https://doi.org/10.1371/journal.pone.0048167","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048167","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048167&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015508594.pdf","grobid_xml":"https://content.openalex.org/works/W2015508594.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1582572722","https://openalex.org/W1754699223","https://openalex.org/W1842383160","https://openalex.org/W1964250224","https://openalex.org/W1971904955","https://openalex.org/W1972183307","https://openalex.org/W1975631945","https://openalex.org/W1982115496","https://openalex.org/W1982322827","https://openalex.org/W1988027525","https://openalex.org/W1990692993","https://openalex.org/W1991657895","https://openalex.org/W2001590540","https://openalex.org/W2003691989","https://openalex.org/W2015177502","https://openalex.org/W2019214006","https://openalex.org/W2022916085","https://openalex.org/W2024654143","https://openalex.org/W2024770739","https://openalex.org/W2052935885","https://openalex.org/W2059112140","https://openalex.org/W2064166204","https://openalex.org/W2065272082","https://openalex.org/W2073853014","https://openalex.org/W2081498817","https://openalex.org/W2090069809","https://openalex.org/W2090104983","https://openalex.org/W2090309899","https://openalex.org/W2110199098","https://openalex.org/W2114653954","https://openalex.org/W2122006486","https://openalex.org/W2122732537","https://openalex.org/W2125642074","https://openalex.org/W2126929348","https://openalex.org/W2134151360","https://openalex.org/W2139559253","https://openalex.org/W2141157874","https://openalex.org/W2141493492","https://openalex.org/W2141653517","https://openalex.org/W2154996893","https://openalex.org/W2156962791","https://openalex.org/W2163348221","https://openalex.org/W2167434897","https://openalex.org/W2169061994","https://openalex.org/W2239902945","https://openalex.org/W2255476504","https://openalex.org/W2268335832","https://openalex.org/W2400250419","https://openalex.org/W2409637797","https://openalex.org/W2412406481","https://openalex.org/W2415427142","https://openalex.org/W2493197887"],"related_works":["https://openalex.org/W7095644572","https://openalex.org/W7061862123","https://openalex.org/W238162054","https://openalex.org/W2019214006","https://openalex.org/W1972834882","https://openalex.org/W2006376640","https://openalex.org/W2168486651","https://openalex.org/W1969057857","https://openalex.org/W2560994165","https://openalex.org/W2473383294"],"abstract_inverted_index":{"\u03b2-Thalassemias":[0],"and":[1,58,110,154,159],"abnormal":[2],"hemoglobin":[3,117],"variants":[4,20,46],"are":[5,47],"among":[6],"the":[7,17,26,38,50,81,116,125],"most":[8],"common":[9,85],"hereditary":[10],"abnormalities":[11],"in":[12,142],"humans.":[13],"Molecular":[14],"characterization":[15],"of":[16,25,44,52,83,145,151],"causative":[18],"genetic":[19,45],"is":[21],"an":[22],"essential":[23],"part":[24],"diagnostic":[27,62],"process.":[28],"In":[29],"geographic":[30],"areas":[31],"with":[32],"high":[33,152],"hemoglobinopathy":[34,53,70],"prevalence,":[35],"such":[36],"as":[37,113,115],"Mediterranean":[39,86,146],"region,":[40],"a":[41,74,143,149],"limited":[42],"number":[43],"responsible":[48],"for":[49,80],"majority":[51],"cases.":[54],"Developing":[55],"reliable,":[56],"rapid":[57],"cost-effective":[59],"mutation-specific":[60],"molecular":[61],"assays":[63],"targeting":[64],"particular":[65,169],"populations":[66,170],"greatly":[67],"facilitates":[68],"routine":[69],"investigations.":[71],"We":[72,123,175],"developed":[73],"one-tube":[75],"single-nucleotide":[76],"primer":[77],"extension":[78],"assay":[79,127,184],"detection":[82],"eight":[84],"\u03b2-thalassemia":[87],"mutations:":[88],"Codon":[89,93,97,107],"5":[90],"(-CT);":[91],"CCT(Pro)->C-,":[92],"6":[94],"(-A);":[95],"GAG(Glu)->G-G,":[96],"8":[98],"(-AA);":[99],"AAG(Lys)->-G,":[100],"IVS-I-1":[101],"(G->A),":[102,106],"IVS-I-6":[103],"(T->C),":[104],"IVS-I-110":[105],"39":[108],"(C->T),":[109],"IVS-II-745":[111],"(C->G),":[112],"well":[114],"S":[118],"variant":[119],"beta":[120],"6(A3)":[121],"Glu>Val.":[122],"validated":[124],"new":[126],"using":[128],"previously":[129],"genotyped":[130],"samples":[131],"obtaining":[132],"100%":[133],"agreement":[134],"between":[135],"independent":[136],"genotyping":[137],"methods.":[138],"Our":[139],"approach,":[140],"applicable":[141],"range":[144],"countries,":[147],"offers":[148],"combination":[150],"accuracy":[153],"rapidity":[155],"exploiting":[156],"standard":[157],"techniques":[158],"widely":[160],"available":[161],"equipment.":[162],"It":[163],"can":[164],"be":[165],"further":[166],"adapted":[167],"to":[168],"by":[171,179],"including/excluding":[172],"assayed":[173],"mutations.":[174],"facilitate":[176],"future":[177],"modifications":[178],"providing":[180],"detailed":[181],"information":[182],"on":[183],"design.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}