{"id":"https://openalex.org/W2015493259","doi":"https://doi.org/10.1111/j.1365-4362.1991.tb04352.x","title":"Specificity of Human Keratinocyte X HeLa Cell Hybrid Murine Monoclonal Antibodies","display_name":"Specificity of Human Keratinocyte X HeLa Cell Hybrid Murine Monoclonal Antibodies","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2015493259","doi":"https://doi.org/10.1111/j.1365-4362.1991.tb04352.x","mag":"2015493259","pmid":"https://pubmed.ncbi.nlm.nih.gov/1816129"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-4362.1991.tb04352.x","doi":"https://doi.org/10.1111/j.1365-4362.1991.tb04352.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-4362.1991.tb04352.x","pdf_url":null,"source":{"id":"https://openalex.org/S32635664","display_name":"International Journal of Dermatology","issn_l":"0011-9059","issn":["0011-9059","1365-4362","1365-4632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036478430","display_name":"Beata Kwiatkowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beata Kwiatkowska","raw_affiliation_strings":["Department of Dermatology, University of California-Irvine, College of Medicine 92717","Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California-Irvine, College of Medicine 92717","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088710519","display_name":"Jerry L. McCullough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerry L. McCullough","raw_affiliation_strings":["Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013311518","display_name":"Gerald D. Weinstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald D. Weinstein","raw_affiliation_strings":["Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052269548","display_name":"Eric J. Stanbridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Stanbridge","raw_affiliation_strings":["Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Microbiology, and Molecular Genetics, University of California\u2014Irvine, College of Medicine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088710519"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12148971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"12","first_page":"860","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.1964000016450882,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9269999861717224},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/stratified-squamous-epithelium","display_name":"stratified squamous epithelium","score":0.824999988079071},{"id":"https://openalex.org/keywords/urothelium","display_name":"urothelium","score":0.781000018119812},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.6629999876022339},{"id":"https://openalex.org/keywords/keratinocyte-differentiation-markers","display_name":"keratinocyte differentiation markers","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.8391703963279724},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.7033931016921997},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6529099941253662},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6344139575958252},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6184627413749695},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.5943970084190369},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5110903382301331},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5070867538452148},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.49997806549072266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4351782202720642},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.42250046133995056},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41030073165893555},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3940317630767822},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.23154348134994507},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22507959604263306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2125309705734253},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0629870593547821},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-4362.1991.tb04352.x","doi":"https://doi.org/10.1111/j.1365-4362.1991.tb04352.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-4362.1991.tb04352.x","pdf_url":null,"source":{"id":"https://openalex.org/S32635664","display_name":"International Journal of Dermatology","issn_l":"0011-9059","issn":["0011-9059","1365-4362","1365-4632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:1816129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1816129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1910277396","display_name":null,"funder_award_id":"CA-19104","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3721189499","display_name":null,"funder_award_id":"AM27110","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1560772847","https://openalex.org/W2016777182","https://openalex.org/W2020758710","https://openalex.org/W2064839854"],"related_works":["https://openalex.org/W2020758710","https://openalex.org/W1978921240","https://openalex.org/W2076059066","https://openalex.org/W1975018777","https://openalex.org/W1994155666","https://openalex.org/W2083953328","https://openalex.org/W2158237897","https://openalex.org/W2027065194","https://openalex.org/W2166692456","https://openalex.org/W2003588055"],"abstract_inverted_index":{"The":[0,77],"immunofluorescent":[1,14],"staining":[2,45,102],"patterns":[3,46],"of":[4],"three":[5,109],"differentiation-specific":[6],"monoclonals":[7,78],"(HLK3,":[8],"HLK7,":[9],"HLK20)":[10],"that":[11],"display":[12],"different":[13],"(IF)":[15],"reactivity":[16,90],"in":[17,24,57,75,122,125],"normal":[18,39,105],"and":[19,29,41,54,60,66,70,72,94,127],"psoriatic":[20],"epidermis,":[21],"were":[22,49],"examined":[23],"basal":[25],"cell":[26,31],"carcinoma":[27,32],"(BCC)":[28],"squamous":[30,98],"(SCC),":[33],"as":[34,36],"well":[35],"other":[37],"human":[38],"epithelial":[40],"nonepithelial":[42,83],"tissues.":[43],"Similar":[44],"within":[47,68],"epidermis":[48,69,106],"seen":[50],"with":[51,82,91],"HLK3":[52],"(intercellular)":[53],"HLK7":[55],"(perinuclear)":[56],"psoriasis,":[58],"SCC,":[59],"BCC.":[61],"HLK20":[62],"selectively":[63],"stained":[64],"BCC":[65],"SCC":[67],"dermis,":[71],"was":[73],"negative":[74],"psoriasis.":[76],"did":[79],"not":[80],"react":[81],"tissues,":[84],"but":[85],"repetitively":[86],"displayed":[87],"positive,":[88],"granular":[89],"simple":[92],"epithelia":[93,99],"transitional":[95],"epithelium.":[96],"Stratified":[97],"showed":[100],"IF":[101],"similar":[103],"to":[104,119],"for":[107],"all":[108],"monoclonals.":[110],"These":[111],"new":[112,116],"monoclonal":[113],"antibodies":[114],"offer":[115],"investigative":[117],"tools":[118],"study":[120],"abnormalities":[121],"keratinocyte":[123],"differentiation":[124],"benign":[126],"malignant":[128],"hyperplastic":[129],"skin":[130],"diseases.":[131]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}