{"id":"https://openalex.org/W2015491183","doi":"https://doi.org/10.1074/jbc.m006227200","title":"Interleukin-4/STAT6 Represses STAT1 and NF-\u03baB-dependent Transcription through Distinct Mechanisms","display_name":"Interleukin-4/STAT6 Represses STAT1 and NF-\u03baB-dependent Transcription through Distinct Mechanisms","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2015491183","doi":"https://doi.org/10.1074/jbc.m006227200","mag":"2015491183","pmid":"https://pubmed.ncbi.nlm.nih.gov/10982806"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m006227200","doi":"https://doi.org/10.1074/jbc.m006227200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006227200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m006227200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034838050","display_name":"Yoshihiro Ohmori","orcid":"https://orcid.org/0000-0002-6069-357X","observed_orcids":["https://orcid.org/0000-0002-6069-357X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoshihiro Ohmori","raw_affiliation_strings":["Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. ohmori@dent.meikai.ac.jp","From the Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. ohmori@dent.meikai.ac.jp","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011844060","display_name":"Thomas A. Hamilton","orcid":"https://orcid.org/0000-0002-9817-242X","observed_orcids":["https://orcid.org/0000-0002-9817-242X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Hamilton","raw_affiliation_strings":["Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195","From the Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"From the Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034838050"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.9404,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.91136778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"275","issue":"48","first_page":"38095","last_page":"38103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9539999961853027},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9440000057220459},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9729999899864197},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/creb-binding-protein","display_name":"CREB-binding protein","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.6589999794960022},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.8560000061988831},{"id":"https://openalex.org/keywords/inflammatory-gene-expression","display_name":"inflammatory gene expression","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C145430368","wikidata":"https://www.wikidata.org/wiki/Q14914613","display_name":"STAT6","level":4,"score":0.8543069362640381},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7631556987762451},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.7527402639389038},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5840964913368225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5703151822090149},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5672110319137573},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5612787008285522},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5336635112762451},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4520733654499054},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44652771949768066},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4425355792045593},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4369966983795166},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41983193159103394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3899230659008026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3063059449195862},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2549455165863037},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11677691340446472},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050856","descriptor_name":"Interferon Regulatory Factor-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m006227200","doi":"https://doi.org/10.1074/jbc.m006227200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006227200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10982806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10982806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m006227200","doi":"https://doi.org/10.1074/jbc.m006227200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006227200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5062867232","display_name":"Integrated EGFR function in cytokine-driven inflammation and cancer","funder_award_id":"P01CA062220","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W44416003","https://openalex.org/W120883790","https://openalex.org/W216009453","https://openalex.org/W1539787113","https://openalex.org/W1546171722","https://openalex.org/W1547225947","https://openalex.org/W1579361634","https://openalex.org/W1588231470","https://openalex.org/W1595927635","https://openalex.org/W1596383605","https://openalex.org/W1601219481","https://openalex.org/W1613446635","https://openalex.org/W1663629126","https://openalex.org/W1679980304","https://openalex.org/W1778529618","https://openalex.org/W1818471554","https://openalex.org/W1875764398","https://openalex.org/W1882823390","https://openalex.org/W1921414939","https://openalex.org/W1968235650","https://openalex.org/W1970569586","https://openalex.org/W1972319496","https://openalex.org/W1972692051","https://openalex.org/W1973422045","https://openalex.org/W1981839833","https://openalex.org/W1987485969","https://openalex.org/W1991164200","https://openalex.org/W1993243592","https://openalex.org/W1994390440","https://openalex.org/W2007694332","https://openalex.org/W2014237818","https://openalex.org/W2015153748","https://openalex.org/W2019835417","https://openalex.org/W2024154370","https://openalex.org/W2029275361","https://openalex.org/W2030865745","https://openalex.org/W2031156245","https://openalex.org/W2031501484","https://openalex.org/W2040256969","https://openalex.org/W2048646059","https://openalex.org/W2052172628","https://openalex.org/W2052779439","https://openalex.org/W2060333964","https://openalex.org/W2062811432","https://openalex.org/W2063517517","https://openalex.org/W2067626539","https://openalex.org/W2090509456","https://openalex.org/W2093184750","https://openalex.org/W2095217266","https://openalex.org/W2105360761","https://openalex.org/W2123898551","https://openalex.org/W2132633540","https://openalex.org/W2134828907","https://openalex.org/W2136098448","https://openalex.org/W2143001254","https://openalex.org/W2143241514","https://openalex.org/W2144120552","https://openalex.org/W2154393492","https://openalex.org/W2163853656","https://openalex.org/W2172413152","https://openalex.org/W2172466148","https://openalex.org/W2173560213","https://openalex.org/W2196799556","https://openalex.org/W2407740578","https://openalex.org/W4242028206","https://openalex.org/W4313333868"],"related_works":["https://openalex.org/W1968235650","https://openalex.org/W1972319496","https://openalex.org/W91171174","https://openalex.org/W2196799556","https://openalex.org/W1990679714","https://openalex.org/W2134828907","https://openalex.org/W4313343522","https://openalex.org/W1629854792","https://openalex.org/W2143001254","https://openalex.org/W1818471554"],"abstract_inverted_index":{"STAT6":[0,37,74,120,127,179,196,222],"mediates":[1,180],"interleukin-4":[2],"(IL-4)-dependent":[3],"positive":[4,84],"and":[5,52,100,184,199],"negative":[6,86],"regulation":[7],"of":[8,25,36,55,73,88,93,104,119,126,157,182,203,220],"inflammatory":[9],"gene":[10,27,64,90,159],"expression.":[11,65,91],"In":[12,66],"the":[13,18,116,124,136,195,218,221],"present":[14],"report":[15],"we":[16],"examined":[17],"molecular":[19],"mechanisms":[20,213],"involved":[21],"in":[22,38,115],"IL-4-induced":[23],"repression":[24,54,103],"reporter":[26,63,89,158],"transcription":[28,51,99,146,160,186],"driven":[29],"by":[30,162,187,217],"STAT1":[31,183],"and/or":[32,58],"NF-kappaB.":[33],"Transient":[34],"expression":[35],"a":[39,70],"STAT6-deficient":[40],"cell":[41],"line":[42],"(HEK":[43],"293)":[44],"conferred":[45],"sensitivity":[46],"to":[47,169],"IL-4":[48,79],"for":[49,53,128,138],"STAT6-dependent":[50],"interferon-gamma":[56],"(IFNgamma)/STAT1-":[57],"tumor":[59],"necrosis":[60],"factor-alpha":[61],"(TNFalpha)/NF-kappaB-driven":[62],"cells":[67],"transfected":[68],"with":[69],"deletion":[71],"mutant":[72],"lacking":[75],"its":[76],"transactivating":[77],"domain,":[78],"could":[80],"not":[81,107],"mediate":[82],"either":[83],"or":[85],"control":[87],"Overexpression":[92],"CREB-binding":[94],"protein":[95],"dramatically":[96],"enhanced":[97],"IL-4/STAT6-stimulated":[98],"overcame":[101],"IL-4-mediated":[102,155],"TNFalpha/NF-kappaB-dependent":[105],"but":[106,164,205],"IFNgamma/STAT1-dependent":[108],"transcription.":[109,172],"A":[110],"single":[111],"amino":[112],"acid":[113],"change":[114],"DNA-binding":[117,223],"domain":[118,198],"(H415A)":[121],"selectively":[122],"reduced":[123],"affinity":[125,137],"IL-4-responsive":[129,149],"STAT":[130],"sequence":[131],"motifs":[132],"(N4)":[133],"without":[134],"affecting":[135],"IFNgamma-responsive":[139],"(GAS)":[140],"sequences":[141],"(N3)":[142],"and,":[143],"accordingly,":[144],"eliminated":[145,154],"from":[147],"an":[148],"promoter.":[150],"Interestingly,":[151],"this":[152],"mutation":[153],"suppression":[156,181],"stimulated":[161],"TNFalpha/NF-kappaB":[163],"retained":[165],"nearly":[166],"full":[167],"capacity":[168],"suppress":[170],"IFNgamma/STAT1-stimulated":[171],"Taken":[173],"together":[174],"these":[175],"results":[176],"demonstrate":[177],"that":[178],"NF-kappaB-dependent":[185],"distinct":[188],"mechanisms.":[189],"Both":[190],"processes":[191],"are":[192,214],"dependent":[193],"upon":[194],"transactivation":[197],"may":[200],"involve":[201],"sequestration":[202],"necessary":[204],"different":[206],"transcriptional":[207],"coactivator":[208],"proteins.":[209],"These":[210],"two":[211],"suppressive":[212],"controlled":[215],"differentially":[216],"nature":[219],"site":[224],"(i.e.":[225],"N3":[226],"versus":[227],"N4).":[228]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}