{"id":"https://openalex.org/W2015486560","doi":"https://doi.org/10.1371/journal.pone.0083252","title":"Proof of the Concept to Use a Malignant B Cell Line Drug Screen Strategy for Identification and Weight of Melphalan Resistance Genes in Multiple Myeloma","display_name":"Proof of the Concept to Use a Malignant B Cell Line Drug Screen Strategy for Identification and Weight of Melphalan Resistance Genes in Multiple Myeloma","publication_year":2013,"publication_date":"2013-12-20","ids":{"openalex":"https://openalex.org/W2015486560","doi":"https://doi.org/10.1371/journal.pone.0083252","mag":"2015486560","pmid":"https://pubmed.ncbi.nlm.nih.gov/24376673","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3869769"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0083252","doi":"https://doi.org/10.1371/journal.pone.0083252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0083252","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0083252&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0083252&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077603718","display_name":"Martin B\u00f8gsted","orcid":"https://orcid.org/0000-0001-9192-1814","observed_orcids":["https://orcid.org/0000-0001-9192-1814"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Martin B\u00f8gsted","raw_affiliation_strings":["Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark ; Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark ; Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078970077","display_name":"Anders Ellern Bilgrau","orcid":"https://orcid.org/0000-0001-9875-2902","observed_orcids":["https://orcid.org/0000-0001-9875-2902"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders E. Bilgrau","raw_affiliation_strings":["Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark ; Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark","Department of Mathematical Sciences, The Faculty of Engineering and Science, Aalborg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark ; Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Department of Mathematical Sciences, The Faculty of Engineering and Science, Aalborg University","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084133067","display_name":"Christopher P. Wardell","orcid":"https://orcid.org/0000-0002-9416-7818","observed_orcids":["https://orcid.org/0000-0002-9416-7818"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher P. Wardell","raw_affiliation_strings":["Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064702344","display_name":"Uta Bertsch","orcid":"https://orcid.org/0000-0001-5584-3951","observed_orcids":["https://orcid.org/0000-0001-5584-3951"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uta Bertsch","raw_affiliation_strings":["Department of Internal Medicine V and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061635867","display_name":"Alexander Schmitz","orcid":"https://orcid.org/0009-0009-6862-6679","observed_orcids":["https://orcid.org/0009-0009-6862-6679"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Alexander Schmitz","raw_affiliation_strings":["Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069588626","display_name":"Julie St\u00f8ve B\u00f8dker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Julie S. B\u00f8dker","raw_affiliation_strings":["Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110965273","display_name":"Malene Krag Kjeldsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Malene K. Kjeldsen","raw_affiliation_strings":["Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055916434","display_name":"Hartmut Goldschmidt","orcid":"https://orcid.org/0000-0003-0961-0035","observed_orcids":["https://orcid.org/0000-0003-0961-0035"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Goldschmidt","raw_affiliation_strings":["Department of Internal Medicine V and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth J. Morgan","raw_affiliation_strings":["Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010675319","display_name":"Karen Dybk\u00e6r","orcid":"https://orcid.org/0000-0003-2488-435X","observed_orcids":["https://orcid.org/0000-0003-2488-435X"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Karen Dybkaer","raw_affiliation_strings":["Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066949744","display_name":"Hans Erik Johnsen","orcid":"https://orcid.org/0000-0001-8253-2913","observed_orcids":["https://orcid.org/0000-0001-8253-2913"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Hans E. Johnsen","raw_affiliation_strings":["Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066949744"],"corresponding_institution_ids":["https://openalex.org/I2799976261"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.4338,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.82796586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"12","first_page":"e83252","last_page":"e83252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/melphalan-resistance","display_name":"melphalan resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/drug-resistance-genes","display_name":"drug resistance genes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/drug-screens","display_name":"drug screens","score":0.7049999833106995},{"id":"https://openalex.org/keywords/resistive-index","display_name":"resistance index","score":0.8489999771118164},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8130000233650208},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6800000071525574},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9919999837875366},{"id":"https://openalex.org/keywords/translocation","display_name":"translocation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/high-dose-melphalan","display_name":"high-dose melphalan","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.9016785025596619},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6192882657051086},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5453176498413086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5204475522041321},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.518235445022583},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4978640079498291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48529738187789917},{"id":"https://openalex.org/C66339696","wikidata":"https://www.wikidata.org/wiki/Q6089397","display_name":"Log-rank test","level":3,"score":0.43497127294540405},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4327831268310547},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32378923892974854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2904192805290222},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20744967460632324},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20210739970207214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1467953324317932}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056741","descriptor_name":"Cyclin D","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056741","descriptor_name":"Cyclin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0083252","doi":"https://doi.org/10.1371/journal.pone.0083252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0083252","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0083252&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2856346","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3869769","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3869769","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3869769","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24376673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24376673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.1622","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.1622","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b2/f6/pone.0083252.PMC3869769.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0778cf153500471da18c26b6bab43813","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0778cf153500471da18c26b6bab43813","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 12, p e83252 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/883034","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Proof_of_the_Concept_to_Use_a_Malignant_B_Cell_Line_Drug_Screen_Strategy_for_Identification_and_Weight_of_Melphalan_Resistance_Genes_in_Multiple_Myeloma_/883034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.atira.dk:publications/56209f4f-778d-485e-807b-4b342332f311","doi":null,"is_oa":false,"landing_page_url":"https://vbn.aau.dk/da/publications/56209f4f-778d-485e-807b-4b342332f311","pdf_url":null,"source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B\u00f8gsted, M, Bilgrau, A E, Wardell, C P, Bertsch, U, Schmitz, A, B\u00f8dker, J S, Kjeldsen, M K, Goldschmidt, H, Morgan, G J, Dybk\u00e6r, K & Johnsen, H E 2013, 'Proof of the concept to use a malignant B cell line drug screen strategy for identification and weight of melphalan resistance genes in multiple myeloma', P L o S One, vol. 8, no. 12, e83252. https://doi.org/10.1371/journal.pone.0083252","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0083252","doi":"https://doi.org/10.1371/journal.pone.0083252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0083252","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0083252&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5091097561","display_name":null,"funder_award_id":"U58 DP004017","funder_id":"https://openalex.org/F4320337383","funder_display_name":"National Center for Chronic Disease Prevention and Health Promotion"}],"funders":[{"id":"https://openalex.org/F4320310455","display_name":"Kr\u00e6ftens Bek\u00e6mpelse","ror":"https://ror.org/03ytt7k16"},{"id":"https://openalex.org/F4320333067","display_name":"Sixth Framework Programme","ror":null},{"id":"https://openalex.org/F4320333265","display_name":"Takeda Oncology","ror":"https://ror.org/05vm7p871"},{"id":"https://openalex.org/F4320337383","display_name":"National Center for Chronic Disease Prevention and Health Promotion","ror":"https://ror.org/021rths28"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015486560.pdf","grobid_xml":"https://content.openalex.org/works/W2015486560.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1595022239","https://openalex.org/W1964770362","https://openalex.org/W1974656498","https://openalex.org/W1975771370","https://openalex.org/W1978377409","https://openalex.org/W1985995033","https://openalex.org/W1992915778","https://openalex.org/W1995852844","https://openalex.org/W1997688789","https://openalex.org/W2006393030","https://openalex.org/W2008886056","https://openalex.org/W2014946770","https://openalex.org/W2015880063","https://openalex.org/W2020234719","https://openalex.org/W2022397091","https://openalex.org/W2022795358","https://openalex.org/W2023560061","https://openalex.org/W2026548544","https://openalex.org/W2033525264","https://openalex.org/W2036200625","https://openalex.org/W2044436186","https://openalex.org/W2045010580","https://openalex.org/W2046408556","https://openalex.org/W2049918224","https://openalex.org/W2056804811","https://openalex.org/W2081675665","https://openalex.org/W2084499660","https://openalex.org/W2088171422","https://openalex.org/W2095264870","https://openalex.org/W2097355553","https://openalex.org/W2099557169","https://openalex.org/W2110168092","https://openalex.org/W2114950491","https://openalex.org/W2119462367","https://openalex.org/W2120474651","https://openalex.org/W2123664981","https://openalex.org/W2124560610","https://openalex.org/W2135326558","https://openalex.org/W2136810538","https://openalex.org/W2139602588","https://openalex.org/W2142323325","https://openalex.org/W2142739240","https://openalex.org/W2149877193","https://openalex.org/W2150997370","https://openalex.org/W2153109789","https://openalex.org/W2154041910","https://openalex.org/W2155165473","https://openalex.org/W2155263246","https://openalex.org/W2156052827","https://openalex.org/W2158768792","https://openalex.org/W2160697532","https://openalex.org/W2169585143","https://openalex.org/W2171504422","https://openalex.org/W2171608750","https://openalex.org/W2171626043","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W1992915778","https://openalex.org/W2625822503","https://openalex.org/W2594764119","https://openalex.org/W2419556407","https://openalex.org/W2439386140","https://openalex.org/W7139325272","https://openalex.org/W104371902","https://openalex.org/W4312048217","https://openalex.org/W2559907413","https://openalex.org/W7096128871"],"abstract_inverted_index":{"In":[0,27,157],"a":[1,10,31,111,158,169],"conceptual":[2],"study":[3,188],"of":[4,13,35,116,192,202],"drug":[5,19,198],"resistance":[6,33,62,65,83,171,204],"we":[7,167],"have":[8],"used":[9],"preclinical":[11],"model":[12],"malignant":[14],"B-cell":[15],"lines":[16],"by":[17,40],"combining":[18],"induced":[20],"growth":[21],"inhibition":[22],"and":[23,49,90,104,119,139,145,165,184],"gene":[24,205],"expression":[25,93],"profiling.":[26],"the":[28,44,71,78,81,96,101,105,128,136,143],"current":[29],"report":[30],"melphalan":[32,61,99,203],"profile":[34],"19":[36],"genes":[37],"were":[38,85],"weighted":[39],"microarray":[41],"data":[42,74],"from":[43],"MRC":[45],"Myeloma":[46],"IX":[47],"trial":[48,73],"time":[50],"to":[51,57,76,173,194],"progression":[52,113,181],"following":[53,152],"high":[54,170],"dose":[55],"melphalan,":[56],"generate":[58],"an":[59,175],"individual":[60],"index.":[63],"The":[64],"index":[66,172],"was":[67,132],"subsequently":[68],"validated":[69],"in":[70,196],"HOVON65/GMMG-HD4":[72],"set":[75],"prove":[77],"concept.":[79],"Biologically,":[80],"assigned":[82],"indices":[84],"differentially":[86],"distributed":[87],"among":[88],"translocations":[89],"cyclin":[91],"D":[92],"classes.":[94],"Clinically,":[95],"25%":[97,106],"most":[98,107],"resistant,":[100],"intermediate":[102,144],"50%":[103],"sensitive":[108,146],"patients":[109],"had":[110],"median":[112,129,155],"free":[114,182],"survival":[115,131,183],"18,":[117],"32":[118],"28":[120],"months,":[121],"respectively":[122],"(log-rank":[123,148],"P-value":[124,149],"=":[125,150],"0.05).":[126],"Furthermore,":[127],"overall":[130,185],"45":[133],"months":[134,154],"for":[135,142,162,200,207],"resistant":[137],"group":[138],"not":[140],"reached":[141],"groups":[147],"0.003)":[151],"38":[153],"observation.":[156],"multivariate":[159],"analysis,":[160],"correcting":[161],"age,":[163],"sex":[164],"ISS-staging,":[166],"found":[168],"be":[174],"independent":[176],"variable":[177],"associated":[178],"with":[179],"inferior":[180],"survival.":[186],"This":[187],"provides":[189],"clinical":[190],"proof":[191],"concept":[193],"use":[195],"vitro":[197],"screen":[199],"identification":[201],"signatures":[206],"future":[208],"functional":[209],"analysis.":[210]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}