{"id":"https://openalex.org/W2015469977","doi":"https://doi.org/10.1097/01.psy.0000195742.24850.79","title":"Opioid Analgesia in Persons at Risk for Hypertension","display_name":"Opioid Analgesia in Persons at Risk for Hypertension","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2015469977","doi":"https://doi.org/10.1097/01.psy.0000195742.24850.79","mag":"2015469977","pmid":"https://pubmed.ncbi.nlm.nih.gov/16449421"},"language":"en","primary_location":{"id":"doi:10.1097/01.psy.0000195742.24850.79","doi":"https://doi.org/10.1097/01.psy.0000195742.24850.79","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.psy.0000195742.24850.79","pdf_url":null,"source":{"id":"https://openalex.org/S78750095","display_name":"Psychosomatic Medicine","issn_l":"0033-3174","issn":["0033-3174","1534-7796","2998-8748","2998-8756"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychosomatic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027987077","display_name":"James A. McCubbin","orcid":"https://orcid.org/0000-0002-1803-4589","observed_orcids":["https://orcid.org/0000-0002-1803-4589"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James A. McCubbin","raw_affiliation_strings":["Department of Psychology, Clemson University, Clemson, SC 29634-1355, USA. jmccubb@clemson.edu","(S.G.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Clemson University, Clemson, SC 29634-1355, USA. jmccubb@clemson.edu","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"(S.G.H.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080144370","display_name":"Suzanne G. Helfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147193464","display_name":"Adrian College","ror":"https://ror.org/02f131c52","country_code":"US","type":"education","lineage":["https://openalex.org/I147193464"]},{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne G. Helfer","raw_affiliation_strings":["From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","and Adrian College, Adrian, MI (S.G.H.)","(S.G.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"and Adrian College, Adrian, MI (S.G.H.)","institution_ids":["https://openalex.org/I147193464"]},{"raw_affiliation_string":"(S.G.H.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054133380","display_name":"Fred S. Switzer","orcid":"https://orcid.org/0000-0002-3538-3959","observed_orcids":["https://orcid.org/0000-0002-3538-3959"]},"institutions":[{"id":"https://openalex.org/I147193464","display_name":"Adrian College","ror":"https://ror.org/02f131c52","country_code":"US","type":"education","lineage":["https://openalex.org/I147193464"]},{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred S. Switzer","raw_affiliation_strings":["From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","and Adrian College, Adrian, MI (S.G.H.)","(S.G.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"and Adrian College, Adrian, MI (S.G.H.)","institution_ids":["https://openalex.org/I147193464"]},{"raw_affiliation_string":"(S.G.H.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021052186","display_name":"Cynthia Galloway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147193464","display_name":"Adrian College","ror":"https://ror.org/02f131c52","country_code":"US","type":"education","lineage":["https://openalex.org/I147193464"]},{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Galloway","raw_affiliation_strings":["From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","and Adrian College, Adrian, MI (S.G.H.)","(S.G.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"and Adrian College, Adrian, MI (S.G.H.)","institution_ids":["https://openalex.org/I147193464"]},{"raw_affiliation_string":"(S.G.H.)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069548268","display_name":"William V. Griffith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147193464","display_name":"Adrian College","ror":"https://ror.org/02f131c52","country_code":"US","type":"education","lineage":["https://openalex.org/I147193464"]},{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William V. Griffith","raw_affiliation_strings":["From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","and Adrian College, Adrian, MI (S.G.H.)","(S.G.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Clemson University (J.A.M., F.S.S., C.G., W.V.G.), Clemson, SC","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"and Adrian College, Adrian, MI (S.G.H.)","institution_ids":["https://openalex.org/I147193464"]},{"raw_affiliation_string":"(S.G.H.)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027987077"],"corresponding_institution_ids":["https://openalex.org/I8078737"],"apc_list":null,"apc_paid":null,"fwci":3.5981,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.93096061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"1","first_page":"116","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.4036000072956085,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.4036000072956085,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.15189999341964722,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hypertension-risk","display_name":"hypertension risk","score":0.8230000138282776},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.6100000143051147},{"id":"https://openalex.org/keywords/pain-sensitivity","display_name":"pain sensitivity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cold-pressor-pain","display_name":"cold pressor pain","score":0.9010000228881836},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.9909999966621399},{"id":"https://openalex.org/keywords/opioid-receptor-antagonism","display_name":"opioid antagonism","score":0.8930000066757202},{"id":"https://openalex.org/keywords/endogenous-opioids","display_name":"endogenous opioids","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hypoalgesia","display_name":"hypoalgesia","score":0.75},{"id":"https://openalex.org/keywords/early-hypertension","display_name":"early hypertension","score":0.42800000309944153},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5978163480758667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49097302556037903},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3663579225540161},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3236372470855713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16096755862236023},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05929732322692871}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006987","descriptor_name":"Hypesthesia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018847","descriptor_name":"Opioid Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/01.psy.0000195742.24850.79","doi":"https://doi.org/10.1097/01.psy.0000195742.24850.79","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.psy.0000195742.24850.79","pdf_url":null,"source":{"id":"https://openalex.org/S78750095","display_name":"Psychosomatic Medicine","issn_l":"0033-3174","issn":["0033-3174","1534-7796","2998-8748","2998-8756"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychosomatic Medicine","raw_type":"journal-article"},{"id":"pmid:16449421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16449421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychosomatic medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.530.5386","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.530.5386","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.psychosomaticmedicine.org/content/68/1/116.full.pdf","raw_type":"text"},{"id":"pmh:oai:tigerprints.clemson.edu:health_pubs-1007","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/health_pubs/9","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G144778713","display_name":null,"funder_award_id":"HL10227","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G461415289","display_name":null,"funder_award_id":"HL-32738","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7661876660","display_name":"INSTRUMENTAL SOCIAL SUPPORT, STRESS, AND BLOOD PRESSURE","funder_award_id":"F32HL010227","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W167717437","https://openalex.org/W1969912544","https://openalex.org/W2003576115","https://openalex.org/W2015212939","https://openalex.org/W2017656459","https://openalex.org/W2024188425","https://openalex.org/W2028226906","https://openalex.org/W2056052585","https://openalex.org/W2057671041","https://openalex.org/W2064178930","https://openalex.org/W2065823549","https://openalex.org/W2075507710","https://openalex.org/W2084207941","https://openalex.org/W2085617589","https://openalex.org/W2097308157","https://openalex.org/W2124992444","https://openalex.org/W2135185875","https://openalex.org/W2138407894","https://openalex.org/W2156121263","https://openalex.org/W2158008590","https://openalex.org/W2323168553","https://openalex.org/W2488972003","https://openalex.org/W4240880433"],"related_works":["https://openalex.org/W1969912544","https://openalex.org/W2126873707","https://openalex.org/W2067343730","https://openalex.org/W2041330589","https://openalex.org/W7008912334","https://openalex.org/W2066632267","https://openalex.org/W1992349415","https://openalex.org/W2012590093","https://openalex.org/W6986790589","https://openalex.org/W2052248328"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Acute":[1],"pain":[2,14,32,50,109,145,171],"sensitivity":[3,33,110],"is":[4,21,34],"reduced":[5],"in":[6,63,89,113,154,178],"clinical":[7],"hypertension,":[8],"but":[9,60],"the":[10,37,64,80,101,139,179],"precise":[11],"relationship":[12],"between":[13,27,42,135,166],"perception":[15],"and":[16,31,49,120,138,161,172],"altered":[17,167,173],"blood":[18,29,46,67,86,129,174],"pressure":[19,30,47,68,175],"control":[20,48,176],"not":[22,71],"well-characterized.":[23],"A":[24],"negative":[25],"correlation":[26],"resting":[28],"observed":[35],"throughout":[36],"normotensive":[38],"range,":[39],"suggesting":[40],"links":[41,165],"basic":[43],"mechanisms":[44,177],"of":[45,66,82,100,141,170,182],"regulation.":[51],"The":[52,74,98],"opioid":[53,102,142,152],"peptides":[54],"are":[55],"important":[56,164],"endogenous":[57,83],"analgesic":[58],"mechanisms,":[59],"their":[61],"role":[62],"hypoalgesia":[65,88],"elevations":[69],"has":[70],"been":[72],"well-established.":[73],"current":[75],"study":[76],"sought":[77],"to":[78,163],"examine":[79],"effects":[81,99,140],"opioids":[84],"on":[85,106,144],"pressure-associated":[87],"young":[90,114],"adults":[91],"at":[92,156],"risk":[93,137,158],"for":[94,159],"hypertension":[95,136,160],"development.":[96],"METHODS:":[97],"receptor":[103],"antagonist,":[104],"naltrexone,":[105],"cold":[107],"pressor":[108],"were":[111],"assessed":[112],"adult":[115],"men":[116],"(n":[117,122],"=":[118,123],"49)":[119],"women":[121],"76)":[124],"with":[125],"mildly":[126],"elevated":[127],"casual":[128],"pressure.":[130],"RESULTS:":[131],"Results":[132],"indicate":[133],"interactions":[134],"blockade":[143],"sensitivity.":[146],"CONCLUSIONS:":[147],"These":[148],"findings":[149],"suggest":[150],"exaggerated":[151],"analgesia":[153],"persons":[155],"enhanced":[157],"point":[162],"neuropeptide":[168],"regulation":[169],"early":[180],"stages":[181],"hypertension.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}