{"id":"https://openalex.org/W2015460086","doi":"https://doi.org/10.1097/00004872-198901000-00004","title":"Atrial natriuretic peptide and exaggerated natriuresis during acute hypertonic volume expansion in essential hypertension","display_name":"Atrial natriuretic peptide and exaggerated natriuresis during acute hypertonic volume expansion in essential hypertension","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2015460086","doi":"https://doi.org/10.1097/00004872-198901000-00004","mag":"2015460086","pmid":"https://pubmed.ncbi.nlm.nih.gov/2523419"},"language":"en","primary_location":{"id":"doi:10.1097/00004872-198901000-00004","doi":"https://doi.org/10.1097/00004872-198901000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-198901000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082193117","display_name":"S\u00f8ren Schwartz S\u00f8rensen","orcid":"https://orcid.org/0000-0001-5898-8048","observed_orcids":["https://orcid.org/0000-0001-5898-8048"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800392737","display_name":"Aarhus Municipality","ror":"https://ror.org/02wwbem66","country_code":"DK","type":"government","lineage":["https://openalex.org/I2800392737"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren S. S\u00f8rensen","raw_affiliation_strings":["Department of Medicine C, Aarhus Kommunehospital, Denmark","the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine C, Aarhus Kommunehospital, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800392737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067932898","display_name":"H. Danielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800392737","display_name":"Aarhus Municipality","ror":"https://ror.org/02wwbem66","country_code":"DK","type":"government","lineage":["https://openalex.org/I2800392737"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henning Danielsen","raw_affiliation_strings":["the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800392737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021621101","display_name":"A. Amdisen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800392737","display_name":"Aarhus Municipality","ror":"https://ror.org/02wwbem66","country_code":"DK","type":"government","lineage":["https://openalex.org/I2800392737"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Amdi Amdisen","raw_affiliation_strings":["the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800392737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103410807","display_name":"Erling Bjerregaard Pedersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800392737","display_name":"Aarhus Municipality","ror":"https://ror.org/02wwbem66","country_code":"DK","type":"government","lineage":["https://openalex.org/I2800392737"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Erling B. Pedersen","raw_affiliation_strings":["the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medicine C, Aarhus Kommunehospital. The Psychopharmacology Research Unit, Psychiatric Hospital in Aarhus and Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800392737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4562,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.92104519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"1","first_page":"21","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.2915000021457672,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.8009999990463257},{"id":"https://openalex.org/keywords/acute-volume-expansion","display_name":"acute volume expansion","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hypertonic-saline","display_name":"hypertonic saline","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/renal-tubular-sodium-reabsorption","display_name":"tubular sodium reabsorption","score":0.8920000195503235},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8930000066757202},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9309999942779541},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":1.0},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lithium-clearance","display_name":"lithium clearance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/sodium-handling","display_name":"sodium handling","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9485568404197693},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.8842377066612244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6224583983421326},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5791586637496948},{"id":"https://openalex.org/C3020062846","wikidata":"https://www.wikidata.org/wiki/Q7940891","display_name":"Volume expansion","level":2,"score":0.5715366005897522},{"id":"https://openalex.org/C117277713","wikidata":"https://www.wikidata.org/wiki/Q925744","display_name":"Tonicity","level":2,"score":0.5213485956192017},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.4758419990539551},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.44679853320121765},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1511077880859375},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.07354962825775146}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009318","descriptor_name":"Natriuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012462","descriptor_name":"Saline Solution, Hypertonic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00004872-198901000-00004","doi":"https://doi.org/10.1097/00004872-198901000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-198901000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:2523419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2523419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/1e0dbdf0-0d52-11de-8317-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/1e0dbdf0-0d52-11de-8317-000ea68e967b","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"S\u00f8rensen, S S, Danielsen, H, Amdisen, A & Pedersen, E B 1989, 'Atrial natriuretic peptide and exaggerated natriuresis during acute hypertonic volume expansion in essential hypertension', Journal of Hypertension, vol. 7 (1), pp. 21-9.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2414114298","https://openalex.org/W7005700418","https://openalex.org/W1965007474","https://openalex.org/W2031254134","https://openalex.org/W2401316753","https://openalex.org/W1978003470","https://openalex.org/W2111819131","https://openalex.org/W1971240219","https://openalex.org/W2415091050","https://openalex.org/W2397053411"],"abstract_inverted_index":{"In":[0,80],"patients":[1,67,86,131,149],"with":[2,43,69,133,169],"essential":[3,187],"hypertension":[4,188],"and":[5,24,36,38,103,110,116,150,175,177,195,200,226],"healthy":[6],"controls,":[7],"plasma":[8],"levels":[9],"of":[10,27,221],"atrial":[11],"natriuretic":[12,210],"peptide":[13],"(ANP),":[14],"angiotensin":[15],"II":[16,174],"(Ang":[17],"II),":[18],"aldosterone":[19],"(Aldo),":[20],"arginine":[21],"vasopressin":[22],"(AVP)":[23],"urinary":[25,122,125],"excretion":[26,127],"prostaglandin":[28],"E2":[29],"(PGE2)":[30],"were":[31,146],"measured":[32],"under":[33,158,192],"basal":[34,61,159,193],"conditions,":[35],"before":[37],"after":[39],"acute":[40,83,166,205,213],"volume":[41,84,167,206,214],"expansion":[42,85,168,215],"a":[44],"2.5%":[45],"hypertonic":[46,165],"sodium":[47,51,113,222],"chloride":[48],"solution.":[49],"Tubular":[50],"handling":[52,220],"was":[53,64,128],"assessed":[54],"by":[55],"the":[56,196],"lithium":[57],"clearance":[58],"technique.":[59],"Under":[60],"conditions":[62,194],"ANP":[63,91,189,201],"increased":[65,191],"in":[66,90,107,130,152,172,180,186,198,223],"compared":[68,132],"controls":[70,134,151],"(9.0":[71],"pmol/l":[72,93],"versus":[73,94,137],"7.5":[74],"pmol/l,":[75,96],"P":[76,97,140],"less":[77,98,141],"than":[78,99,142],"0.01).":[79],"response":[81,211],"to":[82,164,212],"exhibited":[87],"exaggerated":[88,101,203,209],"increases":[89],"(5.3":[92],"3.0":[95],"0.05),":[100],"natriuresis,":[102],"an":[104,178,218],"abnormal":[105],"decrease":[106],"fractional":[108],"proximal":[109,225],"distal":[111,227],"tubular":[112],"reabsorption":[114],"(PFRNa":[115],"DFRNa,":[117],"respectively).":[118],"Furthermore,":[119],"during":[120,204],"comparable":[121,170],"flow":[123],"rates,":[124],"PGE2":[126],"decreased":[129],"(266":[135],"pg/min":[136],"705":[138],"pg/min,":[139],"0.05).":[143],"No":[144],"differences":[145],"found":[147],"between":[148],"Ang":[153,173],"II,":[154],"Aldo":[155],"or":[156],"AVP":[157],"conditions.":[160],"Both":[161],"groups":[162],"responded":[163],"decreases":[171],"Aldo,":[176],"increase":[179,197],"AVP.":[181],"It":[182],"is":[183,190,202],"concluded":[184],"that":[185],"natriuresis":[199],"expansion.":[207],"The":[208],"resulted":[216],"from":[217],"altered":[219],"both":[224],"tubules.":[228]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}