{"id":"https://openalex.org/W2015455079","doi":"https://doi.org/10.1021/bi00359a046","title":"Differential effects of resact analogs on sperm respiration rates and cyclic nucleotide concentrations","display_name":"Differential effects of resact analogs on sperm respiration rates and cyclic nucleotide concentrations","publication_year":1986,"publication_date":"1986-06-03","ids":{"openalex":"https://openalex.org/W2015455079","doi":"https://doi.org/10.1021/bi00359a046","mag":"2015455079","pmid":"https://pubmed.ncbi.nlm.nih.gov/3015204"},"language":"en","primary_location":{"id":"doi:10.1021/bi00359a046","doi":"https://doi.org/10.1021/bi00359a046","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00359a046","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022013480","display_name":"Hiromi Shimomura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiromi Shimomura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073371787","display_name":"David L. Garbers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Garbers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.1425,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85641135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"25","issue":"11","first_page":"3405","last_page":"3410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.43459999561309814,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.43459999561309814,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.24410000443458557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sperm-respiration","display_name":"sperm respiration","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cyclic-nucleotides","display_name":"cyclic nucleotides","score":0.921999990940094},{"id":"https://openalex.org/keywords/peptide-fragments","display_name":"peptide fragments","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cysteine-substitution","display_name":"cysteine substitution","score":0.824999988079071},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.6029999852180481},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6729511618614197},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.5870861411094666},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.5693670511245728},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5268151760101318},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.44757938385009766},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.41072651743888855},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.2844698429107666},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.2432314157485962},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00359a046","doi":"https://doi.org/10.1021/bi00359a046","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00359a046","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:3015204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3015204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3759809352","display_name":"REGULATION OF SPERM NUCLEOTIDE METABOLISM","funder_award_id":"R01HD010254","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W25999916","https://openalex.org/W130682363","https://openalex.org/W654843005","https://openalex.org/W1481688884","https://openalex.org/W1503509391","https://openalex.org/W1522192042","https://openalex.org/W1522747166","https://openalex.org/W1531883069","https://openalex.org/W1642643214","https://openalex.org/W1977896587","https://openalex.org/W1980556867","https://openalex.org/W1987949641","https://openalex.org/W1992427179","https://openalex.org/W2004953784","https://openalex.org/W2016244342","https://openalex.org/W2033785962","https://openalex.org/W2038223713","https://openalex.org/W2047253781","https://openalex.org/W2053719619","https://openalex.org/W2066334670","https://openalex.org/W2068970184","https://openalex.org/W2072109957","https://openalex.org/W2080266074","https://openalex.org/W2094599402","https://openalex.org/W2096510653","https://openalex.org/W2111988068","https://openalex.org/W2113470722","https://openalex.org/W2113728879","https://openalex.org/W2123874680","https://openalex.org/W2128481036","https://openalex.org/W2146033738","https://openalex.org/W2327582829","https://openalex.org/W2487681533","https://openalex.org/W2587538053"],"related_works":["https://openalex.org/W1494855408","https://openalex.org/W2149466700","https://openalex.org/W1642643214","https://openalex.org/W1984752145","https://openalex.org/W2089219089","https://openalex.org/W2113470722","https://openalex.org/W2031017696","https://openalex.org/W2342389219","https://openalex.org/W2333880604","https://openalex.org/W2141459646"],"abstract_inverted_index":{"Analogues":[0],"of":[1,13,20,22,27,39,50,123,129,135,198],"resact":[2,80,91,208],"(Cys-Val-Thr-Gly-Ala-Pro-Gly-Cys-Val-Gly-Gly-Gly-Arg-LeuNH2)":[3],"were":[4,68,143,150,184],"synthesized":[5,166],"to":[6,112],"determine":[7],"whether":[8,61],"or":[9,46,48,64],"not":[10,33],"a":[11,116],"stimulation":[12],"sperm":[14],"respiration":[15,62,83,103,125],"could":[16],"be":[17],"obtained":[18],"independent":[19],"elevations":[21],"cyclic":[23,65,94,106,131,147],"nucleotide":[24,66,107,148],"concentrations.":[25],"Modification":[26],"the":[28,40,51,124,130,138,153,174,196,210],"CO2-terminal":[29,117,177],"leucine":[30],"NH2":[31],"did":[32],"alter":[34],"biological":[35],"activity;":[36],"however,":[37,146],"substitution":[38],"two":[41],"cysteinyl":[42,52],"residues":[43,53],"by":[44],"Ser":[45],"Tyr":[47],"methylation":[49],"resulted":[54],"in":[55,195,209],"divergent":[56],"relative":[57,155],"potencies":[58],"dependent":[59],"on":[60],"rates":[63,84],"concentrations":[67,110,149,156],"measured.":[69],"[Ser1,Tyr8]resact,":[70],"as":[71,77,79,88,90,157,189,191,205,207],"an":[72],"example,":[73],"was":[74,86,164,203],"approximately":[75,121],"40%":[76],"potent":[78,206],"at":[81,92,109,152],"stimulating":[82],"but":[85],"1%":[87],"effective":[89,190],"causing":[93],"GMP":[95,132],"elevations.":[96],"An":[97,161],"NH2-terminal":[98,141,175],"fragment":[99,118],"(Cys-Val-Thr-Gly-Ala-Pro-Gly)":[100],"neither":[101],"stimulated":[102],"nor":[104],"elevated":[105,151],"levels":[108],"up":[111],"10":[113],"microM":[114,200],"whereas":[115],"(Cys-Val-Gly-Gly-Gly-Arg-LeuNH2)":[119],"had":[120],"20%":[122],"activity":[126,134],"and":[127,140,167,176,186],"0.1%":[128],"elevating":[133],"resact.":[136,160],"When":[137],"CO2-":[139],"fragments":[142,178],"added":[144],"simultaneously,":[145],"same":[154],"observed":[158],"with":[159],"analogue":[162],"(125I-[Tyr1,Ser8]resact)":[163],"subsequently":[165],"used":[168],"for":[169,180],"receptor":[170],"binding":[171,212],"studies.":[172],"Both":[173],"competed":[179],"binding,":[181],"although":[182],"they":[183],"0.0004":[185],"0.025":[187],"times":[188],"resact,":[192],"respectively.":[193],"However,":[194],"presence":[197],"1":[199],"resact-(1-7),":[201],"resact-(8-14)":[202],"almost":[204],"competitive":[211],"assay.(ABSTRACT":[213],"TRUNCATED":[214],"AT":[215],"250":[216],"WORDS)":[217]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
