{"id":"https://openalex.org/W2015453241","doi":"https://doi.org/10.2337/diabetes.47.9.1494","title":"Differential effect of the antidiabetic thiazolidinediones troglitazone and pioglitazone on human platelet aggregation mechanism.","display_name":"Differential effect of the antidiabetic thiazolidinediones troglitazone and pioglitazone on human platelet aggregation mechanism.","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2015453241","doi":"https://doi.org/10.2337/diabetes.47.9.1494","mag":"2015453241","pmid":"https://pubmed.ncbi.nlm.nih.gov/9726240"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.47.9.1494","doi":"https://doi.org/10.2337/diabetes.47.9.1494","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.47.9.1494","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034898325","display_name":"Tatsuo Ishizuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Ishizuka","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043944239","display_name":"Satomi Itaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Itaya","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110105972","display_name":"Hisayasu Wada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Wada","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111946933","display_name":"Masayoshi Ishizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ishizawa","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105932143","display_name":"Masashi Kimura","orcid":"https://orcid.org/0000-0003-3425-5004","observed_orcids":["https://orcid.org/0000-0003-3425-5004"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Kimura","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049484965","display_name":"Kazuo Kajita","orcid":"https://orcid.org/0000-0003-0316-6412","observed_orcids":["https://orcid.org/0000-0003-0316-6412"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kajita","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036738100","display_name":"Yoshinori Kanoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kanoh","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Miura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Miura","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037371940","display_name":"Naoya Muto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Muto","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108428709","display_name":"Keigo Yasuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Yasuda","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine, Japan. tishizuk-gif@umin.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I42405503"],"apc_list":null,"apc_paid":null,"fwci":5.1013,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.95800954,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"9","first_page":"1494","last_page":"1500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/troglitazone","display_name":"troglitazone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":1.0},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.9980000257492065},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.8479999899864197},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/phosphoinositide-signaling","display_name":"phosphoinositide signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pi-3-kinase","display_name":"PI3-kinase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8420000076293945},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6259999871253967},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2778150266","wikidata":"https://www.wikidata.org/wiki/Q7844989","display_name":"Troglitazone","level":4,"score":0.9690787196159363},{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.876184344291687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6398925185203552},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5385594964027405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5049551129341125},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4674803912639618},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4350094795227051},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43481773138046265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31418144702911377},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.27736401557922363},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2193719446659088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1902901530265808},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.13743895292282104},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.07914376258850098}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077288","descriptor_name":"Troglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002839","descriptor_name":"Chromans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051571","descriptor_name":"Protein Kinase C-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064546","descriptor_name":"Protein Kinase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diabetes.47.9.1494","doi":"https://doi.org/10.2337/diabetes.47.9.1494","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.47.9.1494","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:9726240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9726240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040840125","https://openalex.org/W2253041227","https://openalex.org/W2035930842","https://openalex.org/W2079238011","https://openalex.org/W1966088481","https://openalex.org/W2076594407","https://openalex.org/W2560319082","https://openalex.org/W1980660426","https://openalex.org/W1972632636","https://openalex.org/W1968195522"],"abstract_inverted_index":{"Troglitazone":[0],"and":[1,38,54,56,72,82,107,129,135,147,156,173,183],"pioglitazone,":[2,37,113,188],"antidiabetic":[3],"thiazolidinediones,":[4],"are":[5],"known":[6],"to":[7,218],"improve":[8],"insulin":[9],"resistance.":[10],"However,":[11,93],"the":[12,33,76,200,210,219],"effect":[13,34,193,221],"of":[14,25,35,46,78,123,199,203,213,222],"these":[15],"drugs":[16],"on":[17,41,194,224],"platelet":[18,43,67,102,195,225],"aggregation":[19,68,196,226],"remains":[20],"unclear.":[21],"The":[22],"chemical":[23,211],"structure":[24,212],"troglitazone":[26,81,106,146,155,172,182,223],"contains":[27],"vitamin":[28,39,85,108,148,184,214],"E.":[29],"Accordingly,":[30],"we":[31],"studied":[32],"troglitazone,":[36],"E":[40,86,215],"thrombin-induced":[42,101,118,163,201],"aggregation,":[44],"metabolism":[45],"phosphoinositide,":[47],"protein":[48,50,131],"phosphorylation,":[49],"kinase":[51],"C":[52],"(PKC)-alpha":[53],"-beta,":[55],"phosphatidylinositol":[57,124],"(PI)":[58],"3-kinase":[59,160,165],"activation":[60,137,166,202],"in":[61,63,75,115,117,138,206,227],"vitro":[62],"human":[64,207,228],"platelets.":[65,208,229],"Maximum":[66],"by":[69,126,143,169],"ADP,":[70],"collagen,":[71],"thrombin":[73],"decreased":[74],"presence":[77],"0.1-1":[79],"micromol/l":[80],"500":[83],"nmol/l":[84],"for":[87,175],"60":[88,176],"min":[89],"compared":[90],"with":[91,105,112,145,152,171],"controls.":[92],"pioglitazone":[94,157,174],"did":[95],"not":[96,111,151,187],"inhibit":[97],"ADP-,":[98],"collagen-,":[99],"or":[100],"aggregation.":[103],"Pretreatment":[104],"E,":[109,149,185],"but":[110,150,162,186],"resulted":[114],"decreases":[116],"phosphatidic":[119],"acid":[120],"production,":[121],"hydrolysis":[122],"4,5-bisphosphate":[125],"phospholipase":[127],"C,":[128],"47-kDa":[130],"phosphorylation.":[132],"Thrombin-induced":[133],"PKC-alpha":[134],"-beta":[136],"membrane":[139],"fraction":[140],"was":[141,167],"suppressed":[142,168],"pretreatment":[144,170],"pioglitazone.":[153],"Separately,":[154],"stimulated":[158],"PI":[159,164],"activity,":[161],"min.":[177],"These":[178],"results":[179],"suggest":[180],"that":[181],"have":[189],"a":[190],"potent":[191],"inhibitory":[192,220],"via":[197],"suppression":[198],"phosphoinositide":[204],"signaling":[205],"Finally,":[209],"may":[216],"contribute":[217]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}