{"id":"https://openalex.org/W2015452592","doi":"https://doi.org/10.1074/jbc.m304153200","title":"Induction of Intestinal ATP-binding Cassette Transporters by a Phytosterol-derived Liver X Receptor Agonist","display_name":"Induction of Intestinal ATP-binding Cassette Transporters by a Phytosterol-derived Liver X Receptor Agonist","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2015452592","doi":"https://doi.org/10.1074/jbc.m304153200","mag":"2015452592","pmid":"https://pubmed.ncbi.nlm.nih.gov/12847102"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m304153200","doi":"https://doi.org/10.1074/jbc.m304153200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m304153200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820834139/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021925820834139/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043784698","display_name":"Emi Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emi Kaneko","raw_affiliation_strings":["Graduate School of Medicine and Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine and Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112641584","display_name":"Morihiro Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Morihiro Matsuda","raw_affiliation_strings":["Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074067640","display_name":"Yukio Yamada","orcid":"https://orcid.org/0000-0002-3747-8767","observed_orcids":["https://orcid.org/0000-0002-3747-8767"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio Yamada","raw_affiliation_strings":["Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100841728","display_name":"Yoji Tachibana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274019","display_name":"Nisshin Flour Milling Inc. (Japan)","ror":"https://ror.org/00wx06002","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274019"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Tachibana","raw_affiliation_strings":["Pharmaceutical Research Center of Nisshin Flour Milling Co., 5-3-1 Tsurugaoka, Ooi-machi, Saitama 356-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Center of Nisshin Flour Milling Co., 5-3-1 Tsurugaoka, Ooi-machi, Saitama 356-8511, Japan","institution_ids":["https://openalex.org/I4405274019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037246488","display_name":"Iichiro Shimomura","orcid":"https://orcid.org/0000-0002-0851-9603","observed_orcids":["https://orcid.org/0000-0002-0851-9603"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Iichiro Shimomura","raw_affiliation_strings":["Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and","Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047196134","display_name":"Makoto Makishima","orcid":"https://orcid.org/0000-0002-4630-905X","observed_orcids":["https://orcid.org/0000-0002-4630-905X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Makoto Makishima","raw_affiliation_strings":["Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and","Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan and","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037246488","https://openalex.org/A5047196134"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.7261,"has_fulltext":true,"cited_by_count":206,"citation_normalized_percentile":{"value":0.96591466,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"278","issue":"38","first_page":"36091","last_page":"36098"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"liver X receptor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lxr-agonists","display_name":"LXR agonists","score":0.8769999742507935},{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.9750000238418579},{"id":"https://openalex.org/keywords/abcg5","display_name":"ABCG5","score":0.9779999852180481},{"id":"https://openalex.org/keywords/abcg8","display_name":"ABCG8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intestinal-cholesterol-absorption","display_name":"intestinal cholesterol absorption","score":0.777999997138977},{"id":"https://openalex.org/keywords/oxysterols","display_name":"oxysterols","score":0.6610000133514404},{"id":"https://openalex.org/keywords/src-1","display_name":"SRC-1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/t0901317","display_name":"T0901317","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intestinal-lipid-metabolism","display_name":"intestinal lipid metabolism","score":0.46799999475479126},{"id":"https://openalex.org/keywords/ergosterol-derivatives","display_name":"ergosterol derivatives","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.9871238470077515},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6643908023834229},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.6575416326522827},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.4852268695831299},{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.4493393003940582},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4462060332298279},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43707767128944397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3915024995803833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3845956325531006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.328042596578598},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.2767411470413208},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.138180673122406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09395816922187805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0788792073726654}],"mesh":[{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006845","descriptor_name":"Hydrocarbons, Fluorinated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006888","descriptor_name":"Hydroxycholesterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010840","descriptor_name":"Phytosterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m304153200","doi":"https://doi.org/10.1074/jbc.m304153200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m304153200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820834139/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12847102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12847102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m304153200","doi":"https://doi.org/10.1074/jbc.m304153200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m304153200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820834139/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309791","display_name":"Suzuken Memorial Foundation","ror":"https://ror.org/03yvcwz92"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015452592.pdf","grobid_xml":"https://content.openalex.org/works/W2015452592.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1501286679","https://openalex.org/W1517802390","https://openalex.org/W1967286688","https://openalex.org/W1973243569","https://openalex.org/W1982715024","https://openalex.org/W1996168740","https://openalex.org/W2000577172","https://openalex.org/W2000581994","https://openalex.org/W2001332055","https://openalex.org/W2008450021","https://openalex.org/W2021206718","https://openalex.org/W2024851295","https://openalex.org/W2027663543","https://openalex.org/W2034790783","https://openalex.org/W2040417680","https://openalex.org/W2046658442","https://openalex.org/W2046659875","https://openalex.org/W2053581007","https://openalex.org/W2059367957","https://openalex.org/W2063612133","https://openalex.org/W2068458442","https://openalex.org/W2082508806","https://openalex.org/W2085909854","https://openalex.org/W2086317930","https://openalex.org/W2095786854","https://openalex.org/W2099378835","https://openalex.org/W2108987650","https://openalex.org/W2112632255","https://openalex.org/W2119133998","https://openalex.org/W2122259365","https://openalex.org/W2129937334","https://openalex.org/W2135007868","https://openalex.org/W2137188051","https://openalex.org/W2147040117","https://openalex.org/W2150680144","https://openalex.org/W2153673003","https://openalex.org/W2156575042","https://openalex.org/W2157817725","https://openalex.org/W2159332620","https://openalex.org/W2165104851","https://openalex.org/W2169319034","https://openalex.org/W2172132693","https://openalex.org/W4244071318","https://openalex.org/W4251360714"],"related_works":["https://openalex.org/W2603980434","https://openalex.org/W2034790783","https://openalex.org/W2426599902","https://openalex.org/W2743744823","https://openalex.org/W2034339368","https://openalex.org/W2018911114","https://openalex.org/W2050294137","https://openalex.org/W2796421920","https://openalex.org/W1973243569","https://openalex.org/W1601481510"],"abstract_inverted_index":{"The":[0,178],"nuclear":[1],"receptors":[2,13],"liver":[3,151],"X":[4],"receptor":[5,125],"(LXR)":[6],"alpha":[7],"and":[8,14,37,45,80,99,112,114,134,150],"LXRbeta":[9,113],"serve":[10],"as":[11,35,87,123,127,129],"oxysterol":[12],"regulate":[15],"the":[16,27,67,73,102,116,130,137,144],"expression":[17,28,68,145],"of":[18,29,43,69,78,83,118,146,156],"genes":[19,71],"involved":[20],"in":[21,72,163],"lipid":[22],"metabolism.":[23,188],"LXR":[24,50,88,105,140,180],"activation":[25],"induces":[26],"ATP-binding":[30],"cassette":[31],"(ABC)":[32],"transporters,":[33],"such":[34,122],"ABCG5":[36],"ABCG8,":[38],"which":[39,94],"inhibit":[40],"intestinal":[41,147,160,170,186],"absorption":[42,172],"cholesterol":[44,171,187],"phytosterols.":[46],"Although":[47,136],"several":[48],"synthetic":[49,139],"agonists":[51],"have":[52,57],"been":[53],"generated,":[54],"these":[55],"compounds":[56],"limited":[58],"clinical":[59],"application,":[60],"because":[61],"they":[62],"cause":[63],"hypertriglycemia":[64],"by":[65],"inducing":[66],"lipogenic":[70,152],"liver.":[74],"We":[75],"synthesized":[76],"derivatives":[77],"phytosterols":[79],"found":[81],"some":[82],"them":[84],"to":[85,97,110],"act":[86],"agonists.":[89],"Among":[90],"them,":[91],"YT-32":[92,107,157,168,182],"[(22E)-ergost-22-ene-1alpha,3beta-diol],":[93],"is":[95,101],"related":[96],"ergosterol":[98],"brassicasterol,":[100],"most":[103],"potent":[104],"agonist.":[106],"directly":[108],"bound":[109],"LXRalpha":[111,119],"induced":[115,143],"interaction":[117],"with":[120],"cofactors,":[121],"steroid":[124],"coactivator-1,":[126],"effectively":[128],"natural":[131],"ligands,":[132],"22(R)-hydroxycholesterol":[133],"24(S),25-epoxycholesterol.":[135],"nonsteroidal":[138],"agonist":[141,181],"T0901317":[142,166],"ABC":[148,161],"transporters":[149,162],"genes,":[153],"oral":[154],"administration":[155],"selectively":[158,184],"activated":[159],"mice.":[164],"Unlike":[165],"treatment,":[167],"inhibited":[169],"without":[173],"increasing":[174],"plasma":[175],"triglyceride":[176],"levels.":[177],"phytosterol-derived":[179],"might":[183],"modulate":[185]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}