{"id":"https://openalex.org/W2015451804","doi":"https://doi.org/10.1021/jm0001525","title":"Design, Synthesis, and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide Analogues of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH2 Cluster for Receptor Activation and Implications in the Design of Nonpeptide Thrombin Receptor Mimetics","display_name":"Design, Synthesis, and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide Analogues of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH2 Cluster for Receptor Activation and Implications in the Design of Nonpeptide Thrombin Receptor Mimetics","publication_year":2000,"publication_date":"2000-12-29","ids":{"openalex":"https://openalex.org/W2015451804","doi":"https://doi.org/10.1021/jm0001525","mag":"2015451804","pmid":"https://pubmed.ncbi.nlm.nih.gov/11462974"},"language":"en","primary_location":{"id":"doi:10.1021/jm0001525","doi":"https://doi.org/10.1021/jm0001525","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0001525","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076188669","display_name":"Kostas A. Alexopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":false,"raw_author_name":"Kostas Alexopoulos","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dimitris Panagiotopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":false,"raw_author_name":"Dimitris Panagiotopoulos","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009553458","display_name":"Thomas Mavromoustakos","orcid":"https://orcid.org/0000-0001-5309-992X","observed_orcids":["https://orcid.org/0000-0001-5309-992X"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":false,"raw_author_name":"Thomas Mavromoustakos","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032749978","display_name":"Panagiotis Fatseas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":false,"raw_author_name":"Panagiotis Fatseas","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090442858","display_name":"Mar\u00eda Cristina Paredes-Carbajal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":false,"raw_author_name":"Maria Christina Paredes-Carbajal","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111647004","display_name":"Dieter Mascher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":false,"raw_author_name":"Dieter Mascher","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054817512","display_name":"Stefan Mihailescu","orcid":"https://orcid.org/0000-0003-3661-4103","observed_orcids":["https://orcid.org/0000-0003-3661-4103"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":false,"raw_author_name":"Stefan Mihailescu","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072960254","display_name":"John Matsoukas","orcid":"https://orcid.org/0000-0001-5554-2964","observed_orcids":["https://orcid.org/0000-0001-5554-2964"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]},{"id":"https://openalex.org/I97553796","display_name":"University of Craiova","ror":"https://ror.org/03s251g81","country_code":"RO","type":"education","lineage":["https://openalex.org/I97553796"]}],"countries":["GR","RO"],"is_corresponding":true,"raw_author_name":"John Matsoukas","raw_affiliation_strings":["Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Patras, Patras 26500, Greece, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens 11635, Greece, Department of Physiology, School of Medicine, UNAM, Mexico DF 04510, Mexico, and Department of Physiology, Faculty of Medicine, University of Craiova, Craiova RO-1100, Romania","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072960254"],"corresponding_institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210127711","https://openalex.org/I97553796"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8355,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.65539283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"44","issue":"3","first_page":"328","last_page":"339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-activated-receptor-1","display_name":"protease-activated receptor 1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cyclic-peptide-analogues","display_name":"cyclic peptide analogues","score":0.8410000205039978},{"id":"https://openalex.org/keywords/d-phenylalanine","display_name":"D-phenylalanine","score":0.4490000009536743},{"id":"https://openalex.org/keywords/diastereomers","display_name":"diastereomers","score":0.6060000061988831},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7519999742507935},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/pharmacophore","display_name":"pharmacophore","score":0.6380000114440918},{"id":"https://openalex.org/keywords/piperazine-derivatives","display_name":"piperazine derivatives","score":0.8849999904632568},{"id":"https://openalex.org/keywords/guanidino-group","display_name":"guanidino group","score":0.7360000014305115},{"id":"https://openalex.org/keywords/smooth-muscle-relaxation","display_name":"smooth muscle relaxation","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9051812291145325},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.781302273273468},{"id":"https://openalex.org/C2776201271","wikidata":"https://www.wikidata.org/wiki/Q409292","display_name":"Piperazine","level":2,"score":0.7360560894012451},{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.6101529598236084},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6013391017913818},{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.5654890537261963},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5558861494064331},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5038871169090271},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.49390608072280884},{"id":"https://openalex.org/C2778886182","wikidata":"https://www.wikidata.org/wiki/Q24769535","display_name":"Thrombin receptor","level":4,"score":0.46604931354522705},{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.412123441696167},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18870899081230164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16687166690826416},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0894518494606018},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018179","descriptor_name":"Receptors, Thrombin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/jm0001525","doi":"https://doi.org/10.1021/jm0001525","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0001525","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:11462974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11462974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:http://helios-eie.ekt.gr:10442/7998","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10442/7998","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:https://helios.eie.gr:10442/7998","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10442/7998","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Chemistry, 44(3), 328-339, (2001)","raw_type":"text"},{"id":"pmh:oai:pandektisint.ekt.gr:10442/7998","doi":null,"is_oa":false,"landing_page_url":"http://helios-eie.ekt.gr/EIE/handle/10442/7998","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Chemistry 44:3(Feb2001):328-339","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W228010362","https://openalex.org/W1487725726","https://openalex.org/W1489529085","https://openalex.org/W1495307817","https://openalex.org/W1668651547","https://openalex.org/W1847187734","https://openalex.org/W1969738964","https://openalex.org/W1987934518","https://openalex.org/W1990500910","https://openalex.org/W1991741054","https://openalex.org/W1994819101","https://openalex.org/W1996052275","https://openalex.org/W1998899308","https://openalex.org/W2001285955","https://openalex.org/W2006849546","https://openalex.org/W2016969337","https://openalex.org/W2026680735","https://openalex.org/W2044080127","https://openalex.org/W2071435247","https://openalex.org/W2072235672","https://openalex.org/W2074384162","https://openalex.org/W2093175816","https://openalex.org/W2095481288","https://openalex.org/W2153444599"],"related_works":["https://openalex.org/W3183286808","https://openalex.org/W2016969337","https://openalex.org/W1987934518","https://openalex.org/W2047219390","https://openalex.org/W2031015772","https://openalex.org/W2006849546","https://openalex.org/W2491575588","https://openalex.org/W2073421986","https://openalex.org/W228010362","https://openalex.org/W2105681292"],"abstract_inverted_index":{"The":[0,172],"novel":[1],"cyclic":[2,150,157],"analogues":[3],"cyclo(Phe-Leu-Leu-Arg-epsilonLys-Dap)":[4],"(1)":[5],"and":[6,21,60,88,111,121,198],"cyclo(D-Phe-Leu-Leu-Arg-epsilonLys-Dap)":[7],"(2),":[8],"which":[9,30,45,70,93,193,220],"differ":[10],"only":[11],"in":[12,44,55,69,75,90,97,148,192],"the":[13,25,39,50,56,71,76,82,86,119,140,149,163,169,180,194,211,216,222],"absolute":[14],"conformation":[15,158],"of":[16,85,108,142,165,174,182],"Phe,":[17],"have":[18,49],"been":[19,32],"designed":[20],"synthesized":[22,218],"based":[23],"upon":[24],"minimal":[26],"peptide":[27],"sequence":[28],"Phe-Leu-Leu-Arg":[29],"has":[31],"found":[33,208],"to":[34,66,81,209,215],"exhibit":[35],"biological":[36],"activity":[37,54],"for":[38,162],"thrombin":[40,170,186],"receptor.":[41,171],"Compound":[42],"1,":[43],"all":[46],"amino":[47,129,146,199,223],"acids":[48],"L-configuration,":[51],"exhibited":[52],"higher":[53],"rat":[57,61],"aorta":[58],"relaxation":[59],"longitudinal":[62],"muscle":[63],"bioassays":[64],"compared":[65,214],"compound":[67,91,100],"2,":[68,101],"Phe":[72,87,120],"residue":[73],"is":[74,79,103,137],"D-configuration.":[77],"This":[78],"attributed":[80],"spatial":[83],"proximity":[84],"Arg":[89,122],"1":[92],"does":[94],"not":[95],"exist":[96],"its":[98],"diastereomeric":[99],"as":[102],"depicted":[104],"from":[105],"a":[106,127,143,155,204],"combination":[107],"NMR":[109],"studies":[110,115],"computational":[112],"analysis.":[113],"Structure-activity":[114],"(SAR)":[116],"showed":[117],"that":[118,136,154],"side":[123],"chains":[124],"along":[125],"with":[126,168],"primary":[128,145],"group":[130,147],"form":[131],"an":[132],"active":[133,184,213],"recognition":[134],"motif":[135],"augmented":[138],"by":[139,179],"presence":[141],"second":[144],"peptide.":[151],"We":[152],"suggest":[153],"comparable":[156],"may":[159],"be":[160,210],"responsible":[161],"interaction":[164],"linear":[166],"TRAPs":[167],"validity":[173],"this":[175],"proposition":[176],"was":[177,207],"tested":[178],"synthesis":[181],"four":[183],"nonpeptide":[185],"receptor":[187],"mimetics.":[188],"Substance":[189],"(S)-N-(6-guanidohexanoyl)-N'-(2-amino-3-phenylpropionyl)piperazine":[190],"(3),":[191],"pharmacophoric":[195,224],"phenyl,":[196],"guanidino,":[197],"groups":[200],"were":[201],"incorporated":[202],"onto":[203],"piperazine":[205],"template,":[206],"most":[212],"other":[217],"compounds":[219],"lack":[221],"group.":[225]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
