{"id":"https://openalex.org/W2015449003","doi":"https://doi.org/10.1002/art.1780170208","title":"Urinary fibrin split products in lupus nephritis. Correlation with other parameters of renal disease","display_name":"Urinary fibrin split products in lupus nephritis. Correlation with other parameters of renal disease","publication_year":1974,"publication_date":"1974-03-01","ids":{"openalex":"https://openalex.org/W2015449003","doi":"https://doi.org/10.1002/art.1780170208","mag":"2015449003","pmid":"https://pubmed.ncbi.nlm.nih.gov/4592571"},"language":"en","primary_location":{"id":"doi:10.1002/art.1780170208","doi":"https://doi.org/10.1002/art.1780170208","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780170208","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065572460","display_name":"Sally L. Marchesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. L. Marchesi","raw_affiliation_strings":["Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066032840","display_name":"Robert G. Aptekar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. G. Aptekar","raw_affiliation_strings":["Department of Orthopedic Surgery, Stanford University Medical School, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Stanford University Medical School, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109924757","display_name":"A D Steinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. D. Steinberg","raw_affiliation_strings":["Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolic, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolic, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111460075","display_name":"H. R. Gralnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. R. Gralnick","raw_affiliation_strings":["Hematology Service, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Service, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112514605","display_name":"John L. Decker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. L. Decker","raw_affiliation_strings":["Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolic, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolic, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5065572460"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":2.8088,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.89137466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"158","last_page":"164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glomerular-fibrin-deposition","display_name":"glomerular fibrin deposition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lupus-disease-activity","display_name":"lupus disease activity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.5370000004768372},{"id":"https://openalex.org/keywords/anti-dna-antibodies","display_name":"anti-DNA antibodies","score":0.9760000109672546},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7149999737739563},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.6650000214576721},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.8992688059806824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6682012677192688},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.6223360300064087},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6118420362472534},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5841469764709473},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5661583542823792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5633870959281921},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5493320226669312},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.4657507836818695},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4604955017566681},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.43216168880462646},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4275628924369812},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.41394859552383423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4108850955963135},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4031161069869995},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.38421833515167236},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.369326651096344},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3183137774467468},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.16069218516349792}],"mesh":[{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D006386","descriptor_name":"Hemagglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.1780170208","doi":"https://doi.org/10.1002/art.1780170208","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780170208","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:4592571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4592571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W63887162","https://openalex.org/W1978622225","https://openalex.org/W1993150697","https://openalex.org/W2031407104","https://openalex.org/W2056986362","https://openalex.org/W2065798304","https://openalex.org/W2077856582","https://openalex.org/W2083360966","https://openalex.org/W2130244707","https://openalex.org/W2217321247","https://openalex.org/W2339481324","https://openalex.org/W2399899211","https://openalex.org/W2413703853","https://openalex.org/W2417109573","https://openalex.org/W2469608489"],"related_works":["https://openalex.org/W2340535183","https://openalex.org/W2370565227","https://openalex.org/W2380068085","https://openalex.org/W2096576397","https://openalex.org/W4238741686","https://openalex.org/W2008639893","https://openalex.org/W2413944397","https://openalex.org/W2052864832","https://openalex.org/W2022650756","https://openalex.org/W1993150697"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"total":[2],"of":[3,6,35,60,64,78,116,141,154],"337":[4],"measurements":[5],"urinary":[7,144],"fibrin(ogen)":[8],"split":[9],"products":[10],"(FDP)":[11],"have":[12],"been":[13],"made":[14,51],"over":[15],"a":[16,30],"2\u2010year":[17],"period":[18],"on":[19],"56":[20],"patients":[21,26,42,68,86,94],"with":[22,57,69,82,87,106,114],"lupus":[23,65,117,142],"nephritis.":[24],"Nineteen":[25],"were":[27,43],"studied":[28,44],"during":[29],"14":[31],"week":[32],"controlled":[33],"trial":[34],"cytoxic":[36],"drug":[37],"therapy":[38],"and":[39,63,110,113,120],"the":[40,90,130,139,152],"remaining":[41],"at":[45],"random":[46],"intervals.":[47],"An":[48],"attempt":[49],"was":[50],"to":[52],"correlate":[53],"FDP":[54,79,102,145],"excretion":[55,91,103],"levels":[56,77,146],"accepted":[58],"parameters":[59],"renal":[61],"disease":[62],"activity.":[66],"While":[67],"significant":[70],"nephritis":[71],"by":[72,92],"other":[73],"criteria":[74],"excreted":[75],"elevated":[76],"when":[80],"compared":[81],"normal":[83],"individuals":[84],"or":[85],"rheumatoid":[88],"arthritis,":[89],"individual":[93,158],"fluctuated":[95],"markedly":[96],"in":[97,129,138,150,157],"sequential":[98],"measurements.":[99],"In":[100],"addition":[101],"correlated":[104],"poorly":[105],"BUN,":[107],"creatinine":[108],"clearance,":[109],"protein":[111],"excretion,":[112],"indicators":[115],"activity":[118],"(C3":[119],"anti\u2010DNA":[121],"levels).":[122],"We":[123],"conclude":[124],"that":[125],"although":[126],"fibrin":[127],"deposition":[128],"glomerulus":[131],"is":[132],"almost":[133],"certainly":[134],"an":[135],"important":[136],"factor":[137],"pathogenesis":[140],"nephritis,":[143],"are":[147],"not":[148],"helpful":[149],"assessing":[151],"progress":[153],"glomerular":[155],"damage":[156],"patients.":[159]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}