{"id":"https://openalex.org/W2015448905","doi":"https://doi.org/10.2337/diacare.17.3.183","title":"Effect of Antecedent Hypoglycemia on Cognitive Function and on Glycemie Thresholds for Counterregulatory Hormone Secretion in Healthy Humans","display_name":"Effect of Antecedent Hypoglycemia on Cognitive Function and on Glycemie Thresholds for Counterregulatory Hormone Secretion in Healthy Humans","publication_year":1994,"publication_date":"1994-03-01","ids":{"openalex":"https://openalex.org/W2015448905","doi":"https://doi.org/10.2337/diacare.17.3.183","mag":"2015448905","pmid":"https://pubmed.ncbi.nlm.nih.gov/8174445"},"language":"en","primary_location":{"id":"doi:10.2337/diacare.17.3.183","doi":"https://doi.org/10.2337/diacare.17.3.183","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.17.3.183","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041399881","display_name":"Michael Mellman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Mellman","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012307088","display_name":"MARIS R. DAVIS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maris R Davis","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061582410","display_name":"Michelle Brisman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Brisman","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071069414","display_name":"Harry Shamoon","orcid":"https://orcid.org/0000-0002-5014-5211","observed_orcids":["https://orcid.org/0000-0002-5014-5211"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry Shamoon","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology, and the Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine\u2008Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":1.3315,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.77883193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"3","first_page":"183","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/counterregulatory-hormones","display_name":"counterregulatory hormones","score":0.753000020980835},{"id":"https://openalex.org/keywords/plasma-glucose","display_name":"plasma glucose","score":0.6759999990463257},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.7059999704360962},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.9810000061988831},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":1.0},{"id":"https://openalex.org/keywords/hypoglycemic-symptoms","display_name":"hypoglycemic symptoms","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.9210000038146973},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.75},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.6489999890327454},{"id":"https://openalex.org/keywords/normoglycemia","display_name":"normoglycemia","score":0.703000009059906},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.43799999356269836},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.8947701454162598},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8305901288986206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8280380964279175},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.774423360824585},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.7675889730453491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6827260255813599},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5953629612922668},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.42478710412979126},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.4113748073577881},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3402954936027527},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.06350788474082947}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diacare.17.3.183","doi":"https://doi.org/10.2337/diacare.17.3.183","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.17.3.183","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:8174445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8174445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4791850569","display_name":"ALTERED EPINEPHRINE RESPONSES IN DIABETES","funder_award_id":"R01DK036617","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G630845642","display_name":null,"funder_award_id":"DK20541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2120952370","https://openalex.org/W2413682213","https://openalex.org/W2034300066","https://openalex.org/W2395029694","https://openalex.org/W2104992190","https://openalex.org/W2148938779","https://openalex.org/W2160378554","https://openalex.org/W2047719843","https://openalex.org/W2074411447","https://openalex.org/W7098019337"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"whether":[3,211],"reduced":[4],"hormonal,":[5],"symptomatic,":[6],"and/or":[7],"cognitive":[8,343],"responses":[9],"to":[10,23,49,146,158,172,276,313],"hypoglycemia":[11,42,70,107,216,241,259,315,352],"are":[12,252],"caused":[13],"by":[14,65,205,350],"an":[15],"increase":[16],"in":[17,52,223,242,317,342,353],"the":[18,224,243,271],"plasma":[19,94,100,129,194,229,262,272,294,303,324],"glucose":[20,45,72,84,95,130,195,230,263,273,295,304,325],"concentration":[21],"required":[22,275],"stimulate":[24],"these":[25],"counterregulatory":[26,135,278],"parameters":[27],"after":[28,105,137,282],"antecedent":[29,106,138,215,284],"hypoglycemia.":[30],"RESEARCH":[31],"DESIGN":[32],"AND":[33],"METHODS:":[34],"We":[35],"studied":[36],"nine":[37],"healthy":[38,354],"volunteers":[39],"during":[40],"stepped":[41],"clamps":[43],"(plasma":[44,71,83],"targets":[46],"from":[47],"80":[48],"50":[50,329],"mg/dl":[51,54,235,268],"10":[53],"steps)":[55],"on":[56],"two":[57],"separate":[58],"days.":[59,186],"The":[60,93],"study":[61,226,245],"was":[62,103],"preceded":[63],"either":[64],"a":[66,78,126,193,228],"2-h":[67,79],"period":[68,80],"of":[69,81,99,133,197,231,257,319,327],"58":[73],"+/-":[74,86,111,117,144,148,156,160,170,174,199,233],"2":[75,87,112,118,145,149,157,161,171,175,200,234],"mg/dl)":[76,88],"or":[77,217],"euglycemia":[82],"94":[85],"for":[89,336,340],"90":[90],"min.":[91],"RESULTS:":[92],"that":[96,334],"triggered":[97],"secretion":[98,132,290,338],"norepinephrine":[101],"(NE)":[102],"lower":[104,269,302],"(control":[108],"=":[109,115],"74":[110],"and":[113,166,288,297,306,339],"experimental":[114,185,244],"67":[116],"mg/dl,":[119,150,162,176],"respectively,":[120],"P":[121,151,163,177],"<":[122,152,164,178,247],"0.005).":[123],"In":[124],"contrast,":[125],"relatively":[127],"higher":[128,293],"stimulated":[131],"other":[134],"hormones":[136],"hypoglycemia:":[139],"growth":[140],"hormone":[141,279,337],"(GH)":[142],"(65":[143],"72":[147],"0.01);":[153,165],"glucagon":[154],"(63":[155],"70":[159],"epinephrine":[167],"(EPI)":[168],"(68":[169],"76":[173],"0.01)":[179],"when":[180],"comparing":[181],"control":[182,225],"days":[183],"with":[184],"Hypoglycemic":[187],"symptoms":[188,256],"were":[189],"first":[190],"observed":[191],"at":[192,227,239,261,292,301,323],"plateau":[196],"59":[198],"mg/dl.":[201,330],"Motor":[202],"function":[203,322,344],"reflected":[204,316],"Digit":[206],"Symbol":[207],"Substitution":[208],"deteriorated":[209,222],"equally":[210],"there":[212,308],"had":[213],"been":[214],"euglycemia.":[218],"Logical":[219],"(immediate)":[220],"memory":[221,321],"54":[232],"but":[236],"remained":[237],"unchanged":[238],"equivalent":[240],"(P":[246],"0.03).":[248],"CONCLUSIONS:":[249],"Our":[250],"conclusions":[251],"as":[253],"follows:":[254],"1)":[255],"moderate":[258],"occur":[260,291],"levels":[264,326],"averaging":[265],"approximately":[266,328],"5-15":[267],"than":[270],"concentrations":[274,296],"trigger":[277],"release;":[280],"2)":[281],"acute":[283],"hypoglycemia,":[285],"glucagon,":[286],"EPI,":[287],"GH":[289],"NE":[298],"is":[299],"released":[300],"concentrations;":[305],"3)":[307],"may":[309],"be":[310,346],"CNS":[311],"adaptation":[312],"prior":[314],"preservation":[318],"logical":[320],"These":[331],"findings":[332],"suggest":[333],"thresholds":[335],"changes":[341],"can":[345],"altered":[347],"very":[348],"acutely":[349],"foregoing":[351],"humans.":[355]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
