{"id":"https://openalex.org/W2015402980","doi":"https://doi.org/10.1038/sj.bjp.0704634","title":"Pharmacological characterization of F\u2010180: a selective human V1a vasopressin receptor agonist of high affinity","display_name":"Pharmacological characterization of F\u2010180: a selective human V1a vasopressin receptor agonist of high affinity","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2015402980","doi":"https://doi.org/10.1038/sj.bjp.0704634","mag":"2015402980","pmid":"https://pubmed.ncbi.nlm.nih.gov/11934825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1573299"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0704634","doi":"https://doi.org/10.1038/sj.bjp.0704634","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0704634","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704634","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704634","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109172473","display_name":"M\u00edriam Andr\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES","FR"],"is_corresponding":false,"raw_author_name":"Miriam Andr\u00e9s","raw_affiliation_strings":["INSERM U 469, 141, rue de la Cardonille, 34094 Montpellier Cedex 05, France","Department of Biochemistry and Molecular Biology, Faculty of Sciences, Basque Country University, P.O. Box 644, E-48080 Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 469, 141, rue de la Cardonille, 34094 Montpellier Cedex 05, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Sciences, Basque Country University, P.O. Box 644, E-48080 Bilbao, Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004402701","display_name":"Miguel Trueba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Trueba","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Sciences, Basque Country University, P.O. Box 644, E-48080 Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Sciences, Basque Country University, P.O. Box 644, E-48080 Bilbao, Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065132245","display_name":"Gilles Guillon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Gilles Guillon","raw_affiliation_strings":["INSERM U 469, 141, rue de la Cardonille, 34094 Montpellier Cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 469, 141, rue de la Cardonille, 34094 Montpellier Cedex 05, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065132245"],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":5.1751,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94658607,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"135","issue":"7","first_page":"1828","last_page":"1836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.08320000022649765,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasopressin-receptor-agonists","display_name":"vasopressin receptor agonists","score":0.8029999732971191},{"id":"https://openalex.org/keywords/vasopressin-v1a-receptor","display_name":"vasopressin V1a receptor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"oxytocin receptor","score":0.656000018119812},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/inositol-phosphate-accumulation","display_name":"inositol phosphate accumulation","score":0.828000009059906},{"id":"https://openalex.org/keywords/cortisol-secretion","display_name":"cortisol secretion","score":0.8569999933242798},{"id":"https://openalex.org/keywords/zona-fasciculata","display_name":"zona fasciculata","score":0.9549999833106995},{"id":"https://openalex.org/keywords/vasopressin-analogue","display_name":"vasopressin analogue","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7887376546859741},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6799420714378357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5603158473968506},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5295083522796631},{"id":"https://openalex.org/C90474776","wikidata":"https://www.wikidata.org/wiki/Q24784390","display_name":"Vasopressin receptor","level":4,"score":0.5232129096984863},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4133356213569641},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3471231162548065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32041168212890625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24301978945732117},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22013920545578003},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.19163581728935242}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015383","descriptor_name":"Zona Fasciculata","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015383","descriptor_name":"Zona Fasciculata","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D018045","descriptor_name":"Receptors, Oxytocin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018045","descriptor_name":"Receptors, Oxytocin","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjp.0704634","doi":"https://doi.org/10.1038/sj.bjp.0704634","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0704634","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704634","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1573299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1573299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:11934825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11934825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjp.0704634","doi":"https://doi.org/10.1038/sj.bjp.0704634","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0704634","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704634","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015402980.pdf","grobid_xml":"https://content.openalex.org/works/W2015402980.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1486425129","https://openalex.org/W1536268728","https://openalex.org/W1549512600","https://openalex.org/W1971146690","https://openalex.org/W1974837681","https://openalex.org/W1986288669","https://openalex.org/W1994715499","https://openalex.org/W1996996770","https://openalex.org/W2007060613","https://openalex.org/W2011329611","https://openalex.org/W2015687644","https://openalex.org/W2016272794","https://openalex.org/W2027467507","https://openalex.org/W2027738686","https://openalex.org/W2043553193","https://openalex.org/W2044500605","https://openalex.org/W2048235565","https://openalex.org/W2057556146","https://openalex.org/W2057640040","https://openalex.org/W2070821979","https://openalex.org/W2073583235","https://openalex.org/W2074631079","https://openalex.org/W2075343329","https://openalex.org/W2088350539","https://openalex.org/W2091666217","https://openalex.org/W2100573158","https://openalex.org/W2128635872","https://openalex.org/W2131706912","https://openalex.org/W2136240744","https://openalex.org/W2158529933","https://openalex.org/W2163657751","https://openalex.org/W2443946626","https://openalex.org/W2500454519","https://openalex.org/W4211165141"],"related_works":["https://openalex.org/W1585891918","https://openalex.org/W7008601593","https://openalex.org/W1973126703","https://openalex.org/W2059849462","https://openalex.org/W1974837681","https://openalex.org/W2164768810","https://openalex.org/W7023747333","https://openalex.org/W120370463","https://openalex.org/W7143611510","https://openalex.org/W2085319220"],"abstract_inverted_index":{"1.":[0],"The":[1,74],"pharmacological":[2,111,220],"properties":[3,122,148,158],"of":[4,71,123,159,172,226],"F-180,":[5],"a":[6,32,162,218],"vasopressin":[7,20,114,210,227],"(VP)":[8],"structural":[9],"analogue,":[10],"were":[11],"determined":[12],"on":[13,54,125,161,169],"CHO":[14,55],"cells":[15,56,173],"expressing":[16,57],"the":[17,36,69,92,103,121,156,200,224],"different":[18],"human":[19,37,58,93,104,137,207],"and":[21,43,81,95,99,133,138,145,186,208],"oxytocin":[22],"(OT)":[23],"receptor":[24,39,48,97,233],"subtypes.":[25,234],"Binding":[26],"experiments":[27],"revealed":[28],"that":[29,62,197,228],"F-180":[30,66,80,86,124,129,160,181,198,213],"exhibited":[31],"high":[33,131],"affinity":[34,132,144],"for":[35,46,78,91,102,113,136,149,206],"V(1a)":[38,59,140,151,203,232],"subtype":[40],"(K(i)=11":[41],"nM)":[42],"was":[44,83,87],"selective":[45,147,202],"this":[47],"subtype.":[49],"2.":[50],"Functional":[51],"studies":[52,168],"performed":[53,167],"receptors":[60,115],"indicate":[61],"similarly":[63],"to":[64,222],"AVP,":[65,180],"can":[67,214],"stimulate":[68],"accumulation":[70,185],"inositol":[72,183],"phosphate.":[73],"activation":[75],"constant":[76],"(K(act))":[77],"both":[79],"AVP":[82],"1.7":[84],"nM.":[85],"also":[88],"an":[89,100],"agonist":[90,204],"V(2)":[94],"V(1b)":[96],"subtypes":[98],"antagonist":[101],"OT":[105],"receptor.":[106],"3.":[107],"Since":[108],"marked":[109],"species":[110],"differences":[112],"have":[116],"been":[117],"described,":[118],"we":[119,166,195],"studied":[120],"various":[126],"mammalian":[127],"species.":[128],"showed":[130],"good":[134],"selectivity":[135],"bovine":[139,175,209],"receptors,":[141],"but":[142],"weak":[143],"non":[146],"rat":[150],"receptors.":[152,211],"4.":[153],"To":[154],"assess":[155],"functional":[157],"native":[163],"biological":[164],"model,":[165],"primary":[170],"cultures":[171],"from":[174],"zona":[176],"fasciculata":[177],"(ZF).":[178],"As":[179],"stimulated":[182],"phosphate":[184],"cortisol":[187],"secretion":[188],"with":[189],"similar":[190],"efficiency.":[191],"5.":[192],"In":[193],"conclusion,":[194],"demonstrate":[196],"is":[199],"first":[201],"described":[205],"Therefore":[212],"be":[215],"used":[216],"as":[217],"powerful":[219],"tool":[221],"characterize":[223],"actions":[225],"are":[229],"mediated":[230],"by":[231]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}