{"id":"https://openalex.org/W2015398199","doi":"https://doi.org/10.1097/00003246-200108000-00013","title":"Iontophoretic delivery of calcium for experimental hydrofluoric acid burns","display_name":"Iontophoretic delivery of calcium for experimental hydrofluoric acid burns","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2015398199","doi":"https://doi.org/10.1097/00003246-200108000-00013","mag":"2015398199","pmid":"https://pubmed.ncbi.nlm.nih.gov/11505130"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-200108000-00013","doi":"https://doi.org/10.1097/00003246-200108000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-200108000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Masatomo Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masatomo Yamashita","raw_affiliation_strings":["Department of Emergency Medicine, University of Tsukuba School of Medicine, 1-1-1, Tennodai, Tsukuba, 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, University of Tsukuba School of Medicine, 1-1-1, Tennodai, Tsukuba, 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mamoru Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Yamashita","raw_affiliation_strings":["Department of Emergency Medicine, University of Tsukuba School of Medicine, 1-1-1, Tennodai, Tsukuba, 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, University of Tsukuba School of Medicine, 1-1-1, Tennodai, Tsukuba, 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082449956","display_name":"Mikio Suzuki","orcid":"https://orcid.org/0000-0001-7743-8666","observed_orcids":["https://orcid.org/0000-0001-7743-8666"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4210088523","display_name":"Nichiban (Japan)","ror":"https://ror.org/004tpxz33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088523"]},{"id":"https://openalex.org/I4405265001","display_name":"Nichiban Co., Ltd. (Japan)","ror":"https://ror.org/03jgr6c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikio Suzuki","raw_affiliation_strings":["From the Department of Emergency Medicine (MY, MY), University of Tsukuba School of Medicine, Tsukuba, Japan","and the Section of Comparative Pathology (HK), Nippon Professional School of Medical Technology, Tokyo, Japan","the Medical Institute (MS, HH), Nichiban Co., Hidaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Emergency Medicine (MY, MY), University of Tsukuba School of Medicine, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"and the Section of Comparative Pathology (HK), Nippon Professional School of Medical Technology, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"the Medical Institute (MS, HH), Nichiban Co., Hidaka, Japan","institution_ids":["https://openalex.org/I4210088523","https://openalex.org/I4405265001"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroyasu Hirai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4210088523","display_name":"Nichiban (Japan)","ror":"https://ror.org/004tpxz33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088523"]},{"id":"https://openalex.org/I4405265001","display_name":"Nichiban Co., Ltd. (Japan)","ror":"https://ror.org/03jgr6c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyasu Hirai","raw_affiliation_strings":["From the Department of Emergency Medicine (MY, MY), University of Tsukuba School of Medicine, Tsukuba, Japan","and the Section of Comparative Pathology (HK), Nippon Professional School of Medical Technology, Tokyo, Japan","the Medical Institute (MS, HH), Nichiban Co., Hidaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Emergency Medicine (MY, MY), University of Tsukuba School of Medicine, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"and the Section of Comparative Pathology (HK), Nippon Professional School of Medical Technology, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"the Medical Institute (MS, HH), Nichiban Co., Hidaka, Japan","institution_ids":["https://openalex.org/I4210088523","https://openalex.org/I4405265001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034860819","display_name":"Hiroshi Kajigaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4210088523","display_name":"Nichiban (Japan)","ror":"https://ror.org/004tpxz33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088523"]},{"id":"https://openalex.org/I4405265001","display_name":"Nichiban Co., Ltd. (Japan)","ror":"https://ror.org/03jgr6c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kajigaya","raw_affiliation_strings":["From the Department of Emergency Medicine (MY, MY), University of Tsukuba School of Medicine, Tsukuba, Japan","and the Section of Comparative Pathology (HK), Nippon Professional School of Medical Technology, Tokyo, Japan","the Medical Institute (MS, HH), Nichiban Co., Hidaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Emergency Medicine (MY, MY), University of Tsukuba School of Medicine, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"and the Section of Comparative Pathology (HK), Nippon Professional School of Medical Technology, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"the Medical Institute (MS, HH), Nichiban Co., Hidaka, Japan","institution_ids":["https://openalex.org/I4210088523","https://openalex.org/I4405265001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":null,"apc_paid":null,"fwci":2.3332,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.86970925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"8","first_page":"1575","last_page":"1578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iontophoresis","display_name":"iontophoresis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/calcium-chloride","display_name":"calcium chloride","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hydrofluoric-acid-burns","display_name":"hydrofluoric acid burns","score":0.984000027179718},{"id":"https://openalex.org/keywords/calcium-gluconate","display_name":"calcium gluconate","score":0.7860000133514404},{"id":"https://openalex.org/keywords/burn-treatment","display_name":"burn treatment","score":0.6669999957084656},{"id":"https://openalex.org/keywords/full-thickness-burns","display_name":"third-degree burns","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9197608232498169},{"id":"https://openalex.org/C183529106","wikidata":"https://www.wikidata.org/wiki/Q1528394","display_name":"Iontophoresis","level":2,"score":0.8161340951919556},{"id":"https://openalex.org/C2776967294","wikidata":"https://www.wikidata.org/wiki/Q209569","display_name":"Hydrofluoric acid","level":2,"score":0.7010898590087891},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6002295613288879},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4122338891029358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1360463798046112},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0695657730102539},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002057","descriptor_name":"Burns, Chemical","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002057","descriptor_name":"Burns, Chemical","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002122","descriptor_name":"Calcium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002122","descriptor_name":"Calcium Chloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002125","descriptor_name":"Calcium Gluconate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002125","descriptor_name":"Calcium Gluconate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006858","descriptor_name":"Hydrofluoric Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007478","descriptor_name":"Iontophoresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003246-200108000-00013","doi":"https://doi.org/10.1097/00003246-200108000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-200108000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:11505130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11505130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1587195035","https://openalex.org/W1662040403","https://openalex.org/W1975127647","https://openalex.org/W1997487539","https://openalex.org/W2021636863","https://openalex.org/W2032169821","https://openalex.org/W2040846117","https://openalex.org/W2060225920","https://openalex.org/W2076035285","https://openalex.org/W2080538378","https://openalex.org/W2082609420","https://openalex.org/W2086966934","https://openalex.org/W2153654060","https://openalex.org/W2280737718"],"related_works":["https://openalex.org/W2384045563","https://openalex.org/W3198166694","https://openalex.org/W6989494023","https://openalex.org/W1992691984","https://openalex.org/W2035292364","https://openalex.org/W1986577518","https://openalex.org/W1975343933","https://openalex.org/W2057293732","https://openalex.org/W1997487539","https://openalex.org/W2064034755"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"examine":[2],"the":[3,28,36,51,86,103,106,199,207,224,234,239,249,254,322],"efficacy":[4,258],"of":[5,8,57,67,105,145,154,259,281,308],"iontophoretic":[6],"delivery":[7,307],"calcium":[9,58,136,146,155,211,282,309],"to":[10,50,311],"experimental":[11,302],"hydrofluoric":[12,90,98,271,303],"acid":[13,91,99,272,304],"burns.":[14,305],"DESIGN:":[15],"Prospective,":[16],"controlled":[17],"study.":[18],"SETTING:":[19],"Institutional":[20],"laboratory.":[21],"SUBJECTS:":[22],"Male":[23],"nude":[24,107],"rats.":[25],"INTERVENTIONS:":[26],"For":[27,85],"in":[29,40,87,208,216,225,233,248,285],"vitro":[30,209,226],"experiment,":[31,89,210,227],"a":[32,41,64,220],"full-thickness":[33,192],"skin":[34,72,74],"from":[35],"back":[37],"was":[38,48,59,78,83,261,265,283,293],"set":[39],"vertical":[42],"flow-through":[43],"diffusion":[44],"cell.":[45],"Calcium":[46],"chloride":[47,156],"applied":[49],"donor":[52],"chamber,":[53],"and":[54,142,148,164,194,290,317],"transdermal":[55,279],"transport":[56,280],"examined":[60],"with":[61,80,135,152,219,238,253],"or":[62,73,298],"without":[63],"voltage":[65],"gradient":[66],"1.5":[68,158],"V.":[69],"Either":[70],"intact":[71],"whose":[75],"stratum":[76],"corneum":[77],"stripped":[79,217,286],"adhesive":[81],"tapes":[82],"used.":[84],"vivo":[88],"burns":[92],"were":[93,110,115,162,167,230,245],"induced":[94],"by":[95,288],"dispensing":[96],"50%":[97],"(50":[100],"microL)":[101],"on":[102],"backs":[104],"rats,":[108],"who":[109],"under":[111],"pentobarbital":[112],"anesthesia.":[113],"Rats":[114],"divided":[116],"into":[117,170],"four":[118],"groups":[119],"(n":[120],"=":[121],"5":[122],"for":[123,301,321],"each":[124],"group):":[125],"control":[126,255],"group":[127,133,140,150,236,251],"(burned":[128],"but":[129],"not":[130],"treated);":[131],"topical":[132,297],"(treated":[134,151],"gluconate":[137],"jelly);":[138],"infiltration":[139,299],"(intradermal":[141],"subcutaneous":[143],"injection":[144],"gluconate);":[147],"iontophoresis":[149,153,235,250,260,289,292],"at":[157,173],"V).":[159],"Burn":[160],"areas":[161,229],"measured":[163],"pathologic":[165],"findings":[166,244],"classified":[168],"microscopically":[169],"five":[171],"stages":[172],"1":[174],"wk:":[175],"stage":[176,180,185,190,195],"1,":[177],"epidermal":[178],"burn;":[179,184,189,193],"2,":[181],"superficial":[182],"dermal":[183,188],"3,":[186],"deep":[187],"4,":[191],"5,":[196],"burn":[197,228],"affecting":[198],"skeletal":[200],"muscle.":[201],"MEASUREMENTS":[202],"AND":[203],"MAIN":[204],"RESULTS:":[205],"In":[206,223],"concentrations":[212],"increased":[213],"significantly":[214,232,246],"only":[215],"skins":[218,287],"1.5-V":[221],"gradient.":[222],"reduced":[231],"compared":[237,252],"other":[240],"three":[241],"groups.":[242],"Pathologic":[243],"improved":[247],"group.":[256],"This":[257],"observed":[262],"when":[263],"it":[264],"initiated":[266],"within":[267],"30":[268],"mins":[269],"after":[270],"burn.":[273],"CONCLUSIONS:":[274],"These":[275],"results":[276],"show":[277],"that":[278,291],"enhanced":[284],"more":[294],"efficacious":[295],"than":[296,314],"therapy":[300],"Iontophoretic":[306],"seems":[310],"be":[312,319],"easier":[313],"intra-arterial":[315,325],"infusion":[316,326],"may":[318],"effective":[320],"lesions":[323],"where":[324],"is":[327],"difficult.":[328]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
