{"id":"https://openalex.org/W2015390870","doi":"https://doi.org/10.1172/jci8678","title":"Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene","display_name":"Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W2015390870","doi":"https://doi.org/10.1172/jci8678","mag":"2015390870","pmid":"https://pubmed.ncbi.nlm.nih.gov/10841514","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/300850"},"language":"en","primary_location":{"id":"doi:10.1172/jci8678","doi":"https://doi.org/10.1172/jci8678","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci8678","pdf_url":"http://www.jci.org/articles/view/8678/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/8678/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004381659","display_name":"Saadia Eddahibi","orcid":"https://orcid.org/0000-0002-0374-019X","observed_orcids":["https://orcid.org/0000-0002-0374-019X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"S. Eddahibi","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France. eddahibi@im3.inserm.fr","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France. eddahibi@im3.inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006822403","display_name":"Na\u00efma Hanoun","orcid":"https://orcid.org/0009-0006-8511-4788","observed_orcids":["https://orcid.org/0009-0006-8511-4788"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405274093","display_name":"Neuropsychopharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle","ror":"https://ror.org/0127nye39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405274093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Hanoun","raw_affiliation_strings":["INSERM Unit\u00e9 288, NeuroPsychoPharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle,","Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 288, NeuroPsychoPharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405274093"]},{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005425707","display_name":"Laurence Lanfumey","orcid":"https://orcid.org/0000-0002-4725-2737","observed_orcids":["https://orcid.org/0000-0002-4725-2737"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"id":"https://openalex.org/I4405274093","display_name":"Neuropsychopharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle","ror":"https://ror.org/0127nye39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405274093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Lanfumey","raw_affiliation_strings":["CHU Henri Mondor Assistance Publique-Hopitaux de Paris , Cr\u00e9teil , France","INSERM Unit\u00e9 288, NeuroPsychoPharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle,","Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Henri Mondor Assistance Publique-Hopitaux de Paris , Cr\u00e9teil , France","institution_ids":["https://openalex.org/I3019246885","https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"INSERM Unit\u00e9 288, NeuroPsychoPharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405274093"]},{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069738672","display_name":"Klaus\u2010Peter Lesch","orcid":"https://orcid.org/0000-0001-8348-153X","observed_orcids":["https://orcid.org/0000-0001-8348-153X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"K.P. Lesch","raw_affiliation_strings":["Department of Psychiatry, University of W\u00fcrzburg, W\u00fcrzburg, Germany","INSERM Unit\u00e9 492 et D\u00e9partement de Physiologie , CHU Henri Mondor Assistance Publique-Hopitaux de Paris , 94010 Cr\u00e9teil , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"INSERM Unit\u00e9 492 et D\u00e9partement de Physiologie , CHU Henri Mondor Assistance Publique-Hopitaux de Paris , 94010 Cr\u00e9teil , France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001844320","display_name":"Bernadette Raffestin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Raffestin","raw_affiliation_strings":["D\u00e9partement de Physiologie, H\u00f4pital Ambroise Par\u00e9, Universit\u00e9 Paris V, Boulogne, France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM ) Unit\u00e9 492 , D\u00e9partement de Physiologie ,","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Physiologie, H\u00f4pital Ambroise Par\u00e9, Universit\u00e9 Paris V, Boulogne, France","institution_ids":["https://openalex.org/I4210133069","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM ) Unit\u00e9 492 , D\u00e9partement de Physiologie ,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038507730","display_name":"M. Hamon","orcid":"https://orcid.org/0000-0002-6579-1849","observed_orcids":["https://orcid.org/0000-0002-6579-1849"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405274093","display_name":"Neuropsychopharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle","ror":"https://ror.org/0127nye39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405274093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Hamon","raw_affiliation_strings":["INSERM Unit\u00e9 288, NeuroPsychoPharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle,","Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 288, NeuroPsychoPharmacologie Mol\u00e9culaire, Cellulaire et Fonctionnelle,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405274093"]},{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210121705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004901419","display_name":"Serge Adnot","orcid":"https://orcid.org/0000-0001-5666-3063","observed_orcids":["https://orcid.org/0000-0001-5666-3063"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Adnot","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM ) Unit\u00e9 492 , D\u00e9partement de Physiologie ,","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France","institution_ids":["https://openalex.org/I4210121705"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM ) Unit\u00e9 492 , D\u00e9partement de Physiologie ,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 492, D\u00e9partement de Physiologie, CHU Henri Mondor Assistance Publique-Hopitaux de Paris, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5004381659"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210097159","https://openalex.org/I4210130325"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":11.1149,"has_fulltext":true,"cited_by_count":332,"citation_normalized_percentile":{"value":0.98729049,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"105","issue":"11","first_page":"1555","last_page":"1562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxic-pulmonary-hypertension","display_name":"hypoxic pulmonary hypertension","score":0.8080000281333923},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.9039999842643738},{"id":"https://openalex.org/keywords/5-htt-knockout-mice","display_name":"5-HTT knockout mice","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pulmonary-vascular-remodeling","display_name":"pulmonary vascular remodeling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pulmonary-vasoconstriction","display_name":"pulmonary vasoconstriction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/right-ventricular-hypertrophy","display_name":"right ventricular hypertrophy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/platelet-serotonin-uptake","display_name":"platelet serotonin uptake","score":0.8709999918937683},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pulmonary-vessels","display_name":"pulmonary vessels","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6154772639274597},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5494786500930786},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5380821228027344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5102636814117432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4481946527957916},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37036195397377014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3364564776420593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27561020851135254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2727220058441162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21328547596931458},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci8678","doi":"https://doi.org/10.1172/jci8678","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci8678","pdf_url":"http://www.jci.org/articles/view/8678/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:10841514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10841514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:300850","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC300850/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci8678","doi":"https://doi.org/10.1172/jci8678","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci8678","pdf_url":"http://www.jci.org/articles/view/8678/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306262","display_name":"Bristol-Myers Squibb Foundation","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015390870.pdf","grobid_xml":"https://content.openalex.org/works/W2015390870.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W58278584","https://openalex.org/W1775749144","https://openalex.org/W1971839073","https://openalex.org/W1983120805","https://openalex.org/W1988403143","https://openalex.org/W1993653750","https://openalex.org/W2011848197","https://openalex.org/W2020277250","https://openalex.org/W2020968632","https://openalex.org/W2035848646","https://openalex.org/W2040336481","https://openalex.org/W2043128979","https://openalex.org/W2060406500","https://openalex.org/W2081635255","https://openalex.org/W2111156355","https://openalex.org/W2132167094","https://openalex.org/W2134362869","https://openalex.org/W2163293935","https://openalex.org/W2171679921","https://openalex.org/W2181526959","https://openalex.org/W2184920316","https://openalex.org/W2205104674","https://openalex.org/W2300090606","https://openalex.org/W2329065056","https://openalex.org/W2332980040","https://openalex.org/W2337229884","https://openalex.org/W2418248128","https://openalex.org/W3023130045"],"related_works":["https://openalex.org/W2040336481","https://openalex.org/W2166049758","https://openalex.org/W2109779629","https://openalex.org/W2080853227","https://openalex.org/W1986398321","https://openalex.org/W7098391297","https://openalex.org/W58278584","https://openalex.org/W2128697694","https://openalex.org/W2007824990","https://openalex.org/W2275048230"],"abstract_inverted_index":{"Hypoxia":[0],"is":[1,22,63,71],"a":[2,121,191],"well-recognized":[3],"stimulus":[4],"for":[5,19,81,130],"pulmonary":[6,11,59,87,143,181,198,203],"blood":[7,107,116],"vessel":[8],"remodeling":[9,91],"and":[10,62,89,114,137,164,202],"hypertension":[12,88],"development.":[13],"One":[14],"mechanism":[15],"that":[16,45,78],"may":[17],"account":[18],"these":[20],"effects":[21],"the":[23,29,46,53,135,171,184],"direct":[24],"action":[25],"of":[26,31,56,118,123,141,178,194],"hypoxia":[27],"on":[28],"expression":[30],"specific":[32],"genes":[33],"involved":[34],"in":[35,58,147,170,183,196],"vascular":[36,60,90,199],"smooth":[37],"muscle":[38],"cell":[39],"(SMC)":[40],"proliferation.":[41],"Previous":[42],"studies":[43],"demonstrated":[44],"serotonin":[47],"(5-hydroxytryptamine;":[48],"5-HT)":[49],"transporter":[50],"(5-HTT)":[51],"mediates":[52],"mitogenic":[54,69],"activity":[55,70],"5-HT":[57,108,112],"SMCs":[61],"overexpressed":[64],"during":[65,73],"hypoxia.":[66,74],"Thus,":[67],"5-HT-related":[68],"increased":[72],"Here,":[75],"we":[76],"report":[77],"mice":[79,101,150],"deficient":[80,110],"5-HTT":[82,195],"(5-HTT(-/-))":[83],"developed":[84],"less":[85,168],"hypoxic":[86,148,180],"than":[92],"paired":[93,155],"5-HTT(+/+)":[94],"controls.":[95,156],"When":[96],"maintained":[97],"under":[98],"normoxia,":[99],"5-HTT(-/-)-mutant":[100],"had":[102],"normal":[103],"hemodynamic":[104],"parameters,":[105],"low":[106],"levels,":[109],"platelet":[111],"uptake,":[113],"unchanged":[115],"levels":[117],"5-hydroxyindoleacetic":[119],"acid,":[120],"metabolite":[122],"5-HT.":[124],"After":[125],"exposure":[126],"to":[127],"10%":[128],"O(2)":[129],"2":[131],"or":[132],"5":[133],"weeks,":[134],"number":[136],"medial":[138],"wall":[139],"thickness":[140],"muscular":[142],"vessels":[144],"were":[145],"reduced":[146],"5-HTT(-/-)":[149,185],"as":[151],"compared":[152],"with":[153],"wild-type":[154],"Concomitantly,":[157],"right":[158,165],"ventricular":[159],"systolic":[160],"pressure":[161],"was":[162],"lower":[163],"ventricle":[166],"hypertrophy":[167],"marked":[169],"mutant":[172],"mice.":[173,186],"This":[174],"occurred":[175],"despite":[176],"potentiation":[177],"acute":[179],"vasoconstriction":[182],"These":[187],"data":[188],"further":[189],"support":[190],"key":[192],"role":[193],"hypoxia-induced":[197],"SMC":[200],"proliferation":[201],"hypertension.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}