{"id":"https://openalex.org/W2015383096","doi":"https://doi.org/10.1182/blood-2006-08-043570","title":"Chemotherapy exposure increases leukemia cell stiffness","display_name":"Chemotherapy exposure increases leukemia cell stiffness","publication_year":2006,"publication_date":"2006-12-19","ids":{"openalex":"https://openalex.org/W2015383096","doi":"https://doi.org/10.1182/blood-2006-08-043570","mag":"2015383096","pmid":"https://pubmed.ncbi.nlm.nih.gov/17179225","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1852256"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2006-08-043570","doi":"https://doi.org/10.1182/blood-2006-08-043570","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-08-043570","pdf_url":"https://ashpublications.org/blood/article-pdf/109/8/3505/1291184/zh800807003505.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/109/8/3505/1291184/zh800807003505.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065031384","display_name":"Wilbur Aaron Lam","orcid":"https://orcid.org/0000-0002-0325-7990","observed_orcids":["https://orcid.org/0000-0002-0325-7990"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilbur A. Lam","raw_affiliation_strings":["Department of Bioengineering and UCSF/University of California, Berkeley, (UCB) Joint Graduate Group in Bioengineering, University of California, Berkeley;","Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California, San Francisco (UCSF);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and UCSF/University of California, Berkeley, (UCB) Joint Graduate Group in Bioengineering, University of California, Berkeley;","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California, San Francisco (UCSF);","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086481996","display_name":"Michael J. Rosenbluth","orcid":"https://orcid.org/0009-0009-6930-7688","observed_orcids":["https://orcid.org/0009-0009-6930-7688"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Rosenbluth","raw_affiliation_strings":["Department of Bioengineering and UCSF/University of California, Berkeley, (UCB) Joint Graduate Group in Bioengineering, University of California, Berkeley;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and UCSF/University of California, Berkeley, (UCB) Joint Graduate Group in Bioengineering, University of California, Berkeley;","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084102341","display_name":"Daniel A. Fletcher","orcid":"https://orcid.org/0000-0002-1890-5364","observed_orcids":["https://orcid.org/0000-0002-1890-5364"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Fletcher","raw_affiliation_strings":["Biophysics Graduate Group, University of California, Berkeley","Department of Bioengineering and UCSF/University of California, Berkeley, (UCB) Joint Graduate Group in Bioengineering, University of California, Berkeley;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Graduate Group, University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Bioengineering and UCSF/University of California, Berkeley, (UCB) Joint Graduate Group in Bioengineering, University of California, Berkeley;","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.8268,"has_fulltext":true,"cited_by_count":252,"citation_normalized_percentile":{"value":0.89439655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"109","issue":"8","first_page":"3505","last_page":"3508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8399999737739563},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":1.0},{"id":"https://openalex.org/keywords/cell-deformability","display_name":"cell deformability","score":0.8339999914169312},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8299999833106995},{"id":"https://openalex.org/keywords/vascular-complications","display_name":"vascular complications","score":0.828000009059906},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6787762641906738},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6649507284164429},{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.6050406098365784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5331100225448608},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5164837837219238},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.48835989832878113},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.4366830289363861},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4248458445072174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3739001750946045},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32479774951934814},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32294392585754395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2670992612838745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07191774249076843}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2006-08-043570","doi":"https://doi.org/10.1182/blood-2006-08-043570","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-08-043570","pdf_url":"https://ashpublications.org/blood/article-pdf/109/8/3505/1291184/zh800807003505.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1852256","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1852256","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:17179225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17179225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2006-08-043570","doi":"https://doi.org/10.1182/blood-2006-08-043570","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-08-043570","pdf_url":"https://ashpublications.org/blood/article-pdf/109/8/3505/1291184/zh800807003505.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306442","display_name":"National Childhood Cancer Foundation","ror":"https://ror.org/01521js97"},{"id":"https://openalex.org/F4320309411","display_name":"University of California Berkeley","ror":"https://ror.org/01an7q238"},{"id":"https://openalex.org/F4320315321","display_name":"Cancer Research Coordinating Committee","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320338286","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015383096.pdf","grobid_xml":"https://content.openalex.org/works/W2015383096.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1939017986","https://openalex.org/W1964613765","https://openalex.org/W1977271246","https://openalex.org/W1988158019","https://openalex.org/W2007243735","https://openalex.org/W2010227280","https://openalex.org/W2017142945","https://openalex.org/W2026875866","https://openalex.org/W2031719167","https://openalex.org/W2034653352","https://openalex.org/W2035956150","https://openalex.org/W2059897671","https://openalex.org/W2064933070","https://openalex.org/W2078782272","https://openalex.org/W2084338558","https://openalex.org/W2115040066","https://openalex.org/W2170755361","https://openalex.org/W2310701426","https://openalex.org/W2471004782","https://openalex.org/W3150248096","https://openalex.org/W4239713289","https://openalex.org/W4254888452"],"related_works":["https://openalex.org/W7099038526","https://openalex.org/W2589898755","https://openalex.org/W127252207","https://openalex.org/W2300686355","https://openalex.org/W7168035624","https://openalex.org/W2005178791","https://openalex.org/W124043662","https://openalex.org/W2885840690","https://openalex.org/W2064718674","https://openalex.org/W3094002975"],"abstract_inverted_index":{"Deformability":[0],"of":[1,37,81,101,107,145],"blood":[2,29],"cells":[3,50],"is":[4],"known":[5],"to":[6,12,22,69,128],"influence":[7],"vascular":[8,13,146],"flow":[9],"and":[10,46,57,97,104,124],"contribute":[11],"complications.":[14],"Medications":[15],"for":[16,119],"hematologic":[17],"diseases":[18],"have":[19],"the":[20,35,105,132,143],"potential":[21],"modulate":[23],"these":[24],"complications":[25,147],"if":[26],"they":[27],"alter":[28],"cell":[30,41,59,74,102,116,121],"deformability.":[31],"Here":[32],"we":[33],"report":[34],"effect":[36],"chemotherapy":[38,112,139],"on":[39,111],"leukemia":[40,49,73],"mechanical":[42],"properties.":[43],"Acute":[44],"lymphoblastic":[45],"acute":[47,149],"myeloid":[48],"were":[51],"incubated":[52],"with":[53,63,115],"standard":[54],"induction":[55],"chemotherapy,":[56],"individual":[58],"stiffness":[60,75,91,108],"was":[61],"tracked":[62],"atomic":[64],"force":[65],"microscopy.":[66],"When":[67],"exposed":[68],"dexamethasone":[70],"or":[71],"daunorubicin,":[72],"increased":[76],"by":[77],"nearly":[78],"2":[79],"orders":[80],"magnitude,":[82],"which":[83],"decreased":[84],"their":[85],"passage":[86],"through":[87],"microfluidic":[88],"channels.":[89],"This":[90],"increase":[92,109,142],"occurred":[93,118],"before":[94],"caspase":[95],"activation":[96],"peaked":[98],"after":[99],"completion":[100],"death,":[103],"rate":[106],"depended":[110],"type.":[113],"Stiffening":[114],"death":[117],"all":[120],"types":[122],"investigated":[123],"may":[125,141],"be":[126],"due":[127],"dynamic":[129],"changes":[130],"in":[131,148],"actin":[133],"cytoskeleton.":[134],"These":[135],"observations":[136],"suggest":[137],"that":[138],"itself":[140],"risk":[144],"leukemia.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
