{"id":"https://openalex.org/W2015364584","doi":"https://doi.org/10.1002/ejoc.200600157","title":"A Simple Stereoselective Route to \u03b1\u2010Trifluoromethyl Analogues of Piperidine Alkaloids","display_name":"A Simple Stereoselective Route to \u03b1\u2010Trifluoromethyl Analogues of Piperidine Alkaloids","publication_year":2006,"publication_date":"2006-06-07","ids":{"openalex":"https://openalex.org/W2015364584","doi":"https://doi.org/10.1002/ejoc.200600157","mag":"2015364584"},"language":"en","primary_location":{"id":"doi:10.1002/ejoc.200600157","doi":"https://doi.org/10.1002/ejoc.200600157","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejoc.200600157","pdf_url":null,"source":{"id":"https://openalex.org/S21317199","display_name":"European Journal of Organic Chemistry","issn_l":"1099-0690","issn":["1099-0690","1434-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039926303","display_name":"Annabelle Bariau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155675","display_name":"Clermont-Ferrand\u2019s Superior National School of Chemistry","ror":"https://ror.org/04cxrqq60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I198244214","https://openalex.org/I4210123221","https://openalex.org/I4210155675","https://openalex.org/I4387154249"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Annabelle Bariau","raw_affiliation_strings":["Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]},{"raw_affiliation_string":"Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026501406","display_name":"Wahid Bux Jatoi","orcid":"https://orcid.org/0000-0002-4891-4851","observed_orcids":["https://orcid.org/0000-0002-4891-4851"]},"institutions":[{"id":"https://openalex.org/I4210155675","display_name":"Clermont-Ferrand\u2019s Superior National School of Chemistry","ror":"https://ror.org/04cxrqq60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I198244214","https://openalex.org/I4210123221","https://openalex.org/I4210155675","https://openalex.org/I4387154249"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wahid Bux Jatoi","raw_affiliation_strings":["Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]},{"raw_affiliation_string":"Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045767484","display_name":"Pierre Calinaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155675","display_name":"Clermont-Ferrand\u2019s Superior National School of Chemistry","ror":"https://ror.org/04cxrqq60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I198244214","https://openalex.org/I4210123221","https://openalex.org/I4210155675","https://openalex.org/I4387154249"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Calinaud","raw_affiliation_strings":["Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]},{"raw_affiliation_string":"Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108126742","display_name":"Yves Troin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155675","display_name":"Clermont-Ferrand\u2019s Superior National School of Chemistry","ror":"https://ror.org/04cxrqq60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I198244214","https://openalex.org/I4210123221","https://openalex.org/I4210155675","https://openalex.org/I4387154249"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Yves Troin","raw_affiliation_strings":["Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]},{"raw_affiliation_string":"Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103970356","display_name":"Jean\u2010Louis Canet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155675","display_name":"Clermont-Ferrand\u2019s Superior National School of Chemistry","ror":"https://ror.org/04cxrqq60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I198244214","https://openalex.org/I4210123221","https://openalex.org/I4210155675","https://openalex.org/I4387154249"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Louis Canet","raw_affiliation_strings":["Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie des He\u0301te\u0301rocycles et des Glucides, EA 987, Ecole Nationale Supe\u0301rieure de Chimie de Clermont-Ferrand, Universite\u0301 Blaise Pascal, 63174 Aubie\u0300re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]},{"raw_affiliation_string":"Laboratoire de Chimie des H\u00e9t\u00e9rocycles et des Glucides, EA 987, Ecole Nationale Sup\u00e9rieure de Chimie de Clermont\u2010Ferrand, Universit\u00e9 Blaise Pascal, 63174 Aubi\u00e8re cedex, France","institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108126742"],"corresponding_institution_ids":["https://openalex.org/I4210155675","https://openalex.org/I4405258658"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":0.9287,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.6855116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2006","issue":"15","first_page":"3421","last_page":"3433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperidine-alkaloids","display_name":"piperidine alkaloids","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stereoselective-synthesis","display_name":"stereoselective synthesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/diastereoselectivity","display_name":"diastereoselectivity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/4-piperidones","display_name":"4-piperidones","score":0.8659999966621399},{"id":"https://openalex.org/keywords/intramolecular-mannich-reaction","display_name":"intramolecular Mannich reaction","score":0.9179999828338623},{"id":"https://openalex.org/keywords/trifluoromethyl-protecting-group","display_name":"trifluoromethyl protecting group","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9527812004089355},{"id":"https://openalex.org/C2776442012","wikidata":"https://www.wikidata.org/wiki/Q2302144","display_name":"Trifluoromethyl","level":3,"score":0.9223897457122803},{"id":"https://openalex.org/C2781462491","wikidata":"https://www.wikidata.org/wiki/Q410234","display_name":"Piperidine","level":2,"score":0.9075431823730469},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.8632415533065796},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.6846991777420044},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5813109874725342},{"id":"https://openalex.org/C2780640045","wikidata":"https://www.wikidata.org/wiki/Q183055","display_name":"Mannich reaction","level":3,"score":0.4566279351711273},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3905459940433502},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07798272371292114},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ejoc.200600157","doi":"https://doi.org/10.1002/ejoc.200600157","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejoc.200600157","pdf_url":null,"source":{"id":"https://openalex.org/S21317199","display_name":"European Journal of Organic Chemistry","issn_l":"1099-0690","issn":["1099-0690","1434-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Organic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1566080486","https://openalex.org/W1976584026","https://openalex.org/W1984880675","https://openalex.org/W1989778645","https://openalex.org/W1995370492","https://openalex.org/W2004047353","https://openalex.org/W2011465690","https://openalex.org/W2014509546","https://openalex.org/W2018487459","https://openalex.org/W2019788589","https://openalex.org/W2032828708","https://openalex.org/W2033497449","https://openalex.org/W2050204815","https://openalex.org/W2051542700","https://openalex.org/W2057476365","https://openalex.org/W2061957367","https://openalex.org/W2063700634","https://openalex.org/W2063915017","https://openalex.org/W2070335499","https://openalex.org/W2078731297","https://openalex.org/W2121395743","https://openalex.org/W2145153523","https://openalex.org/W2157666750","https://openalex.org/W2164415338","https://openalex.org/W2167382484","https://openalex.org/W2174286721","https://openalex.org/W2949107093","https://openalex.org/W2949962046","https://openalex.org/W2951430548","https://openalex.org/W2952955579","https://openalex.org/W2952968645","https://openalex.org/W2953073526","https://openalex.org/W4235454828"],"related_works":["https://openalex.org/W2951064134","https://openalex.org/W3191438513","https://openalex.org/W2033497449","https://openalex.org/W2035464502","https://openalex.org/W4302759525","https://openalex.org/W2126060625","https://openalex.org/W2011465690","https://openalex.org/W4306907105","https://openalex.org/W4393946958","https://openalex.org/W1978405132"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"highly":[2],"diastereoselective":[3],"synthesis":[4],"of":[5,9,38],"five":[6],"trifluoro\u2010substituted":[7],"analogues":[8],"mono\u2010,":[10],"di\u2010,":[11],"and":[12,41],"trisubstituted":[13],"piperidine":[14],"alkaloids":[15],"was":[16],"accomplished":[17],"in":[18],"two":[19],"to":[20],"four":[21],"steps":[22],"from":[23],"2\u2010trifluoromethyl":[24],"keto\u2010protected":[25],"4\u2010piperidones,":[26],"prepared":[27],"by":[28],"an":[29],"intramolecular":[30],"Mannich\u2010type":[31],"reaction":[32],"methodology.":[33],"A":[34],"simple":[35],"stereoselective":[36],"elaboration":[37],"new":[39],"2\u2010(trifluoromethyl)\u20104\u2010piperidinols":[40],"4\u2010amino\u20102\u2010(trifluoromethyl)piperidines":[42],"is":[43],"also":[44],"described.":[45],"(\u00a9":[46],"Wiley\u2010VCH":[47],"Verlag":[48],"GmbH":[49],"&":[50],"Co.":[51],"KGaA,":[52],"69451":[53],"Weinheim,":[54],"Germany,":[55],"2006)":[56]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}