{"id":"https://openalex.org/W2015356286","doi":"https://doi.org/10.1016/j.neuint.2003.09.009","title":"Glial activation and pathological pain","display_name":"Glial activation and pathological pain","publication_year":2004,"publication_date":"2004-04-26","ids":{"openalex":"https://openalex.org/W2015356286","doi":"https://doi.org/10.1016/j.neuint.2003.09.009","mag":"2015356286","pmid":"https://pubmed.ncbi.nlm.nih.gov/15145553"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuint.2003.09.009","doi":"https://doi.org/10.1016/j.neuint.2003.09.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuint.2003.09.009","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046557028","display_name":"Julie Wieseler\u2010Frank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julie Wieseler-Frank","raw_affiliation_strings":["Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA. frankjw@psych.colorado.edu","Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA. frankjw@psych.colorado.edu","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011957342","display_name":"Steven F. Maier","orcid":"https://orcid.org/0000-0002-3370-6160","observed_orcids":["https://orcid.org/0000-0002-3370-6160"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven F Maier","raw_affiliation_strings":["Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025282582","display_name":"Linda R. Watkins","orcid":"https://orcid.org/0000-0002-5870-388X","observed_orcids":["https://orcid.org/0000-0002-5870-388X"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda R Watkins","raw_affiliation_strings":["Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309-0345, USA","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046557028"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":null,"fwci":13.8093,"has_fulltext":false,"cited_by_count":267,"citation_normalized_percentile":{"value":0.99367231,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"45","issue":"2-3","first_page":"389","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathological-pain","display_name":"pathological pain","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8479999899864197},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.921999990940094},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cx3cl1","display_name":"fractalkine","score":1.0},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neuronal-glial-interactions","display_name":"neuron-glia interactions","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.8045910000801086},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7599586248397827},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5515232682228088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49571144580841064},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.482260525226593},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.47891080379486084},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.4212223291397095},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3778654634952545},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2831859290599823},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21749866008758545},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18109965324401855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1596035659313202},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuint.2003.09.009","doi":"https://doi.org/10.1016/j.neuint.2003.09.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuint.2003.09.009","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},{"id":"doi:10.1016/s0197-0186(03)00301-2","doi":"https://doi.org/10.1016/s0197-0186(03)00301-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0197-0186(03)00301-2","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},{"id":"pmid:15145553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15145553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1395805143","display_name":null,"funder_award_id":"NS 38020","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1809295588","display_name":"Immune /Glial Mediation of Exaggerated Pain States","funder_award_id":"K02DA015642","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G1865353920","display_name":"PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEIN","funder_award_id":"R01NS038020","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2092865088","display_name":"Acute Stress and Macrophage Priming","funder_award_id":"F32AI051093","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3205351289","display_name":null,"funder_award_id":"DA-15642","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3724547990","display_name":"ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITIS","funder_award_id":"R01NS040696","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5561120335","display_name":"Pain control via spinal interleukin-10 gene therapy","funder_award_id":"R21DA015656","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G599019117","display_name":null,"funder_award_id":"NS40696","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6629551566","display_name":null,"funder_award_id":"AI51093","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7194767943","display_name":null,"funder_award_id":"DA015656","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W646741695","https://openalex.org/W1504724650","https://openalex.org/W1613847106","https://openalex.org/W1629086159","https://openalex.org/W1646647792","https://openalex.org/W1906993142","https://openalex.org/W1963918819","https://openalex.org/W1964616080","https://openalex.org/W1968402792","https://openalex.org/W1974093633","https://openalex.org/W1978515480","https://openalex.org/W1981014302","https://openalex.org/W1984153222","https://openalex.org/W1984252894","https://openalex.org/W1988015066","https://openalex.org/W1990604057","https://openalex.org/W1992206444","https://openalex.org/W1998781594","https://openalex.org/W1999771185","https://openalex.org/W2004915376","https://openalex.org/W2010040350","https://openalex.org/W2010067410","https://openalex.org/W2010166433","https://openalex.org/W2015756509","https://openalex.org/W2021132159","https://openalex.org/W2029503801","https://openalex.org/W2029549981","https://openalex.org/W2030685002","https://openalex.org/W2039414634","https://openalex.org/W2042324518","https://openalex.org/W2043217368","https://openalex.org/W2044730840","https://openalex.org/W2049390031","https://openalex.org/W2050234839","https://openalex.org/W2053916112","https://openalex.org/W2055197670","https://openalex.org/W2057621238","https://openalex.org/W2058615066","https://openalex.org/W2059442704","https://openalex.org/W2068384471","https://openalex.org/W2071029493","https://openalex.org/W2075097757","https://openalex.org/W2076175139","https://openalex.org/W2081887464","https://openalex.org/W2083375671","https://openalex.org/W2086129363","https://openalex.org/W2088163920","https://openalex.org/W2092413554","https://openalex.org/W2096330567","https://openalex.org/W2102023851","https://openalex.org/W2113221031","https://openalex.org/W2113617025","https://openalex.org/W2116903459","https://openalex.org/W2123269821","https://openalex.org/W2132582699","https://openalex.org/W2133316133","https://openalex.org/W2135230448","https://openalex.org/W2139118538","https://openalex.org/W2146061835","https://openalex.org/W2147749740","https://openalex.org/W2155555128","https://openalex.org/W2156364336","https://openalex.org/W2158230836","https://openalex.org/W2162730620","https://openalex.org/W2170019750","https://openalex.org/W4242020052","https://openalex.org/W6699017977"],"related_works":["https://openalex.org/W2126575561","https://openalex.org/W2354896268","https://openalex.org/W2071391649","https://openalex.org/W2088045917","https://openalex.org/W2009182920","https://openalex.org/W2134557769","https://openalex.org/W3032216373","https://openalex.org/W2412551333","https://openalex.org/W2254459223","https://openalex.org/W3033991892"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":22}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}