{"id":"https://openalex.org/W2015348188","doi":"https://doi.org/10.3109/10731199209119643","title":"Hemoglobin-Based Oxygen Carriers (HBOCs): Structural Alterations that Affect Free Radical Generation","display_name":"Hemoglobin-Based Oxygen Carriers (HBOCs): Structural Alterations that Affect Free Radical Generation","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2015348188","doi":"https://doi.org/10.3109/10731199209119643","mag":"2015348188","pmid":"https://pubmed.ncbi.nlm.nih.gov/1391442"},"language":"en","primary_location":{"id":"doi:10.3109/10731199209119643","doi":"https://doi.org/10.3109/10731199209119643","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10731199209119643","pdf_url":null,"source":{"id":"https://openalex.org/S159739878","display_name":"Artificial Cells Blood Substitutes and Biotechnology","issn_l":"1055-7172","issn":["1055-7172","1073-1199","1532-4184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials, Artificial Cells and Immobilization Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078640285","display_name":"Abdu I. Alayash","orcid":"https://orcid.org/0000-0002-2899-6757","observed_orcids":["https://orcid.org/0000-0002-2899-6757"]},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. I. Alayash","raw_affiliation_strings":["Center for Biologics Evaluation and Research, Bethesda, MD","Center for Biologies Evaluation and Research, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biologics Evaluation and Research, Bethesda, MD","institution_ids":["https://openalex.org/I1318287680"]},{"raw_affiliation_string":"Center for Biologies Evaluation and Research, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1318287680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056473458","display_name":"Beth A. Brockner Ryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. A. Brockner Ryan","raw_affiliation_strings":["Center for Biologies Evaluation and Research, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biologies Evaluation and Research, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1318287680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113635908","display_name":"Joseph C. Fratantoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Fratantoni","raw_affiliation_strings":["Center for Biologies Evaluation and Research, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biologies Evaluation and Research, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1318287680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107412810","display_name":"Joseph Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bonaventura","raw_affiliation_strings":["Duke University Marine Biomedical Center, Beaufort, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Marine Biomedical Center, Beaufort, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060269662","display_name":"Celia Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Bonaventura","raw_affiliation_strings":["Duke University Marine Biomedical Center, Beaufort, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Marine Biomedical Center, Beaufort, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4407,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61214286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"2-4","first_page":"277","last_page":"281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-based-oxygen-carriers","display_name":"hemoglobin-based oxygen carriers","score":0.9990000128746033},{"id":"https://openalex.org/keywords/free-radical-production","display_name":"free radical generation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hemoglobin-oxidation","display_name":"hemoglobin oxidation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/oxygen-affinity","display_name":"oxygen affinity","score":0.5009999871253967},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9269999861717224},{"id":"https://openalex.org/keywords/formaldehyde-formation","display_name":"formaldehyde formation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ferric-hemoglobin","display_name":"ferric hemoglobin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/aniline-hydroxylation","display_name":"aniline hydroxylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thiourea","display_name":"thiourea","score":0.6949999928474426},{"id":"https://openalex.org/keywords/mannitol","display_name":"mannitol","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.89887535572052},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.7226382493972778},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5537461638450623},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5358335375785828},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.4566771388053894},{"id":"https://openalex.org/C2775930285","wikidata":"https://www.wikidata.org/wiki/Q161210","display_name":"Formaldehyde","level":2,"score":0.4277232885360718},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4134519398212433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2498958706855774},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20225289463996887},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11374589800834656}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001802","descriptor_name":"Blood Substitutes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10731199209119643","doi":"https://doi.org/10.3109/10731199209119643","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10731199209119643","pdf_url":null,"source":{"id":"https://openalex.org/S159739878","display_name":"Artificial Cells Blood Substitutes and Biotechnology","issn_l":"1055-7172","issn":["1055-7172","1073-1199","1532-4184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials, Artificial Cells and Immobilization Biotechnology","raw_type":"journal-article"},{"id":"pmid:1391442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1391442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1484198152","https://openalex.org/W1502235800","https://openalex.org/W1505536992","https://openalex.org/W1554849134","https://openalex.org/W1605002548","https://openalex.org/W1972924509","https://openalex.org/W2008081488","https://openalex.org/W2097744068","https://openalex.org/W2107950730"],"related_works":["https://openalex.org/W2082020711","https://openalex.org/W2265824391","https://openalex.org/W2050905302","https://openalex.org/W2059424392","https://openalex.org/W4205638011","https://openalex.org/W2792582298","https://openalex.org/W1979329899","https://openalex.org/W2803334048","https://openalex.org/W2135156659","https://openalex.org/W2050459095"],"abstract_inverted_index":{"We":[0],"examined":[1],"how":[2],"changes":[3,104,137],"in":[4,153,177,185,190],"oxygen":[5],"affinity":[6],"brought":[7],"about":[8],"by":[9,28,42,159],"different":[10],"chemical":[11],"modifications":[12],"of":[13,31,45,52,58,62,83,122,127,135,144,148,161],"hemoglobins":[14,22],"affect":[15],"their":[16,191],"oxidation-reduction":[17],"reactions.":[18],"The":[19,141,180],"three":[20],"modified":[21],"studied":[23],"were":[24,86,115],"HbA-FMDA,":[25],"HbBv-FMDA,":[26],"produced":[27,41],"the":[29,43,72,81,109,120,133,145,149,174],"reaction":[30,44,73],"human":[32,46],"or":[33,129,195],"bovine":[34],"oxyHb":[35,53],"with":[36,48,119,197],"fumaryl":[37],"mono-dibromoaspirin;":[38],"and":[39,94,138,165],"HbA-DBBF,":[40,90],"deoxyHb":[47],"bis(3,5-dibromosalicyl)":[49],"fumarate.":[50],"Exposure":[51,98],"to":[54,66,71,99,151,193],"H2O2":[55,100],"causes":[56],"generation":[57],"free":[59,123,154,198],"radicals":[60],"capable":[61],"cleaving":[63],"dimethylsulfoxide":[64],"(Me2SO)":[65],"produce":[67],"formaldehyde":[68],"(HCHO).":[69],"Relative":[70],"rate":[74,134],"for":[75,89,92,96,108],"HbAo":[76],"(630":[77],"+/-":[78],"130":[79],"M/min)":[80],"rates":[82,107,114,121,172],"HCHO":[84,139],"formation":[85],"roughly":[87],"70%":[88],"50%":[91],"HbA-FMDA":[93],"16%":[95],"HbBv-FMDA.":[97],"also":[101],"caused":[102],"spectral":[103,136],"at":[105],"varied":[106],"HBOCs":[110,150,176,184],"analyzed.":[111],"Although":[112],"these":[113,186],"not":[116],"directly":[117],"correlated":[118],"radical":[124,155],"formation,":[125],"addition":[126],"mannitol":[128],"thiourea":[130],"slowed":[131],"both":[132,178],"formation.":[140],"relative":[142],"ability":[143,192],"ferric":[146],"derivatives":[147],"participate":[152],"reactions":[156],"was":[157],"monitored":[158],"assays":[160,187],"non-enzymatic":[162],"NADPH":[163],"oxidation":[164],"aniline":[166],"hydroxylation.":[167],"HbBv-FMDA":[168],"showed":[169],"significantly":[170],"slower":[171],"than":[173],"other":[175],"assays.":[179],"observed":[181],"differences":[182,189],"between":[183],"indicate":[188],"generate":[194],"interact":[196],"radicals.":[199]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
