{"id":"https://openalex.org/W2015338902","doi":"https://doi.org/10.1016/0014-5793(95)00550-s","title":"Characterization of a novel protein\u2010binding module \u2014 the WW domain","display_name":"Characterization of a novel protein\u2010binding module \u2014 the WW domain","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2015338902","doi":"https://doi.org/10.1016/0014-5793(95)00550-s","mag":"2015338902","pmid":"https://pubmed.ncbi.nlm.nih.gov/7641887"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(95)00550-s","doi":"https://doi.org/10.1016/0014-5793(95)00550-s","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(95)00550-s","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2015338902"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058298248","display_name":"Marius Sudol","orcid":"https://orcid.org/0000-0003-3051-6406","observed_orcids":["https://orcid.org/0000-0003-3051-6406"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marius Sudol","raw_affiliation_strings":["Laboratory of Molecular Oncology, Rockefeller University, New York, NY 10021, USA","Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Rockefeller University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069058837","display_name":"Henry I. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry I. Chen","raw_affiliation_strings":["Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049531350","display_name":"C\u00e9cile Bougeret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecile Bougeret","raw_affiliation_strings":["Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004386494","display_name":"Aaron Einbond","orcid":"https://orcid.org/0000-0003-1734-6641","observed_orcids":["https://orcid.org/0000-0003-1734-6641"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Einbond","raw_affiliation_strings":["Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074309419","display_name":"Peer Bork","orcid":"https://orcid.org/0000-0002-2627-833X","observed_orcids":["https://orcid.org/0000-0002-2627-833X"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peer Bork","raw_affiliation_strings":["EMBL, 69012 Heidelberg and Max-Delbruck-Center for Molecular Medicine, 13122 Berlin-Buch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL, 69012 Heidelberg and Max-Delbruck-Center for Molecular Medicine, 13122 Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I4210138560"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058298248"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.7443,"has_fulltext":false,"cited_by_count":396,"citation_normalized_percentile":{"value":0.86982249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"369","issue":"1","first_page":"67","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ww-domain","display_name":"WW domain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7379999756813049},{"id":"https://openalex.org/keywords/proline-rich-motif","display_name":"proline-rich motif","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.5630000233650208},{"id":"https://openalex.org/keywords/tryptophan-residues","display_name":"tryptophan residues","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C204491159","wikidata":"https://www.wikidata.org/wiki/Q24726881","display_name":"WW domain","level":3,"score":0.8372467756271362},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.8084909915924072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6422709822654724},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.5543375611305237},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5151718854904175},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.5105549097061157},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4953412115573883},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.49228158593177795},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40678972005844116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30667203664779663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30512136220932007},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24286425113677979},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.24183562397956848},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20325157046318054},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13957104086875916}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051575","descriptor_name":"Proto-Oncogene Proteins c-yes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(95)00550-s","doi":"https://doi.org/10.1016/0014-5793(95)00550-s","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(95)00550-s","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:7641887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7641887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G156391993","display_name":null,"funder_award_id":"CA 01605","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3293222746","display_name":null,"funder_award_id":"5T32GM07739-16","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8179224827","display_name":"FUNCTIONAL ANALYSIS OF PROTO-ONCOGENES","funder_award_id":"K04CA001605","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8798105863","display_name":"Weill Cornell/Rockefeller/Sloan Kettering MST Program","funder_award_id":"T32GM007739","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320314023","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W94709363","https://openalex.org/W624924830","https://openalex.org/W1749710960","https://openalex.org/W1829412071","https://openalex.org/W1891969776","https://openalex.org/W1969153299","https://openalex.org/W1990061019","https://openalex.org/W1990516841","https://openalex.org/W2014428378","https://openalex.org/W2031920726","https://openalex.org/W2044548055","https://openalex.org/W2046109302","https://openalex.org/W2048472525","https://openalex.org/W2049480511","https://openalex.org/W2065033398","https://openalex.org/W2069116251","https://openalex.org/W2084140421","https://openalex.org/W2091124764","https://openalex.org/W2150295206","https://openalex.org/W2159452410","https://openalex.org/W2170939558","https://openalex.org/W2215206078","https://openalex.org/W2336964174","https://openalex.org/W2413696966"],"related_works":["https://openalex.org/W2033152875","https://openalex.org/W1999948064","https://openalex.org/W2009126761","https://openalex.org/W2011186424","https://openalex.org/W1994375000","https://openalex.org/W2474175655","https://openalex.org/W2007698657","https://openalex.org/W1604166471","https://openalex.org/W2119903691","https://openalex.org/W94709363"],"abstract_inverted_index":{"We":[0,29],"have":[1,90,125],"identified,":[2],"characterized":[3],"and":[4,8,53,105,122,136,192],"cloned":[5],"human,":[6],"mouse":[7],"chicken":[9],"cDNA":[10,86],"of":[11,24,38,58,62,69,84,95,99,142],"a":[12,43,81,85,116,145,163],"novel":[13],"protein":[14,44,189],"that":[15,46,127,148,158,187,193],"binds":[16,131],"to":[17,138],"the":[18,25,39,59,67,77,96,111,128,139,152,159],"Src":[19,176],"homology":[20,177],"domain":[21,98,141,161],"3":[22,178],"(SH3)":[23,179],"Yes":[26],"proto-oncogene":[27],"product.":[28],"subsequently":[30],"named":[31,75,103],"it":[32,76],"YAP":[33,40,100],"for":[34],"Yes-associated":[35],"protein.":[36],"Analysis":[37],"sequence":[41,64,108],"revealed":[42,115],"module":[45],"was":[47],"found":[48],"in":[49,165],"various":[50],"structural,":[51],"regulatory":[52],"signaling":[54],"molecules.":[55],"Because":[56],"one":[57],"prominent":[60],"features":[61],"this":[63,183],"motif":[65,130],"is":[66,149],"presence":[68],"two":[70,92,112],"conserved":[71],"tryptophans":[72],"(W),":[73],"we":[74,89,102,185],"WW":[78,97,140,160],"domain.":[79],"Using":[80],"functional":[82,202],"screen":[83],"expression":[87],"library,":[88],"identified":[91],"putative":[93],"ligands":[94],"which":[101],"WBP-1":[104],"WBP-2.":[106],"Peptide":[107],"comparison":[109],"between":[110],"partial":[113],"clones":[114],"homologous":[117],"proline-rich":[118,129,170,199],"region.":[119],"Binding":[120],"assays":[121],"site-specific":[123],"mutagenesis":[124],"shown":[126],"with":[132,144],"relatively":[133],"high":[134],"affinity":[135],"specificity":[137],"YAP,":[143],"preliminary":[146],"consensus":[147],"different":[150],"from":[151,175],"SH3-binding":[153],"PXXP":[154],"motif.":[155],"This":[156],"suggests":[157],"has":[162],"role":[164],"mediating":[166],"protein-protein":[167],"interactions":[168],"via":[169],"regions,":[171],"similar":[172],"but":[173],"distinct":[174],"domains.":[180],"Based":[181],"on":[182],"finding,":[184],"hypothesize":[186],"additional":[188],"modules":[190],"exist":[191],"they":[194],"could":[195],"be":[196],"isolated":[197],"using":[198],"peptides":[200],"as":[201],"probes.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
