{"id":"https://openalex.org/W2015337645","doi":"https://doi.org/10.1042/bj20111617","title":"Domain assembly of NAADP-gated two-pore channels","display_name":"Domain assembly of NAADP-gated two-pore channels","publication_year":2011,"publication_date":"2011-10-13","ids":{"openalex":"https://openalex.org/W2015337645","doi":"https://doi.org/10.1042/bj20111617","mag":"2015337645","pmid":"https://pubmed.ncbi.nlm.nih.gov/21992073","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3242506"},"language":"en","primary_location":{"id":"doi:10.1042/bj20111617","doi":"https://doi.org/10.1042/bj20111617","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20111617","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1042/bj20111617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051592206","display_name":"Dev Churamani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dev Churamani","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108433255","display_name":"Robert Hooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Robert Hooper","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085776987","display_name":"Eugen Brailoiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugen Brailoiu","raw_affiliation_strings":["Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086481218","display_name":"Sandip Patel","orcid":"https://orcid.org/0000-0001-7247-2013","observed_orcids":["https://orcid.org/0000-0001-7247-2013"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sandip Patel","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051592206","https://openalex.org/A5086481218","https://openalex.org/A5108433255"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":2.249,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.85299145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"441","issue":"1","first_page":"317","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/two-pore-channels","display_name":"two-pore channels","score":0.9670000076293945},{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tpc1","display_name":"TPC1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/channel-assembly","display_name":"channel assembly","score":0.7089999914169312},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.7590000033378601},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dimers","display_name":"dimers","score":0.6589999794960022},{"id":"https://openalex.org/keywords/tetramer","display_name":"tetramer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pore-loop","display_name":"pore loop","score":0.8220000267028809},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5872262120246887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.501842737197876},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42035233974456787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1768854856491089},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.05142927169799805},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1042/bj20111617","doi":"https://doi.org/10.1042/bj20111617","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20111617","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2247643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3242506","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3242506","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3242506","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:21992073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21992073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.1395","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.1395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6e/fb/Biochem_J_2012_Jan_1_441(Pt_1)_317-323.tar.gz","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1326540","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1326540/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BIOCHEMICAL JOURNAL , 441 pp. 317-323. (2012)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1042/bj20111617","doi":"https://doi.org/10.1042/bj20111617","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20111617","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2741465026","display_name":"The molecular basis for calcium release by NAADP","funder_award_id":"BB/G013721/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W186230142","https://openalex.org/W1615545200","https://openalex.org/W1895963467","https://openalex.org/W1964384026","https://openalex.org/W1964549513","https://openalex.org/W1965590635","https://openalex.org/W1968004900","https://openalex.org/W1968966344","https://openalex.org/W1969637387","https://openalex.org/W1972080672","https://openalex.org/W1975832881","https://openalex.org/W1979482249","https://openalex.org/W1988252217","https://openalex.org/W1990708583","https://openalex.org/W1992199981","https://openalex.org/W1995138459","https://openalex.org/W2011432266","https://openalex.org/W2029205502","https://openalex.org/W2030691340","https://openalex.org/W2031675835","https://openalex.org/W2031790758","https://openalex.org/W2033242114","https://openalex.org/W2033961874","https://openalex.org/W2035066043","https://openalex.org/W2037388166","https://openalex.org/W2037708728","https://openalex.org/W2046253303","https://openalex.org/W2047510863","https://openalex.org/W2055221223","https://openalex.org/W2061436416","https://openalex.org/W2065368005","https://openalex.org/W2066094716","https://openalex.org/W2069945478","https://openalex.org/W2069954126","https://openalex.org/W2071089917","https://openalex.org/W2073308483","https://openalex.org/W2076442408","https://openalex.org/W2078502414","https://openalex.org/W2079010149","https://openalex.org/W2082625926","https://openalex.org/W2088421990","https://openalex.org/W2089033487","https://openalex.org/W2089067304","https://openalex.org/W2093768785","https://openalex.org/W2104885055","https://openalex.org/W2112045725","https://openalex.org/W2112686808","https://openalex.org/W2128498401","https://openalex.org/W2143125286","https://openalex.org/W2146447679","https://openalex.org/W2155239512"],"related_works":["https://openalex.org/W2085642554","https://openalex.org/W2046253303","https://openalex.org/W651720316","https://openalex.org/W2067490887","https://openalex.org/W1986274720","https://openalex.org/W4245405659","https://openalex.org/W2759238042","https://openalex.org/W2767655374","https://openalex.org/W2000270473","https://openalex.org/W2089488598"],"abstract_inverted_index":{"TPCs":[0,18,70,185],"(two-pore":[1],"channels)":[2],"have":[3,19],"recently":[4],"been":[5],"identified":[6],"as":[7,189],"targets":[8],"for":[9],"the":[10,57,79,82,111,147,177,205],"Ca2+-mobilizing":[11],"messenger":[12],"NAADP":[13],"(nicotinic":[14],"acid-adenine":[15],"dinucleotide":[16],"phosphate).":[17],"a":[20,39,42],"unique":[21],"structure":[22],"consisting":[23],"of":[24,68,73,88,94,99,106,110,132,140,165,210],"cytosolic":[25,44],"termini,":[26],"two":[27,113],"hydrophobic":[28,107,154],"domains":[29,83],"(I":[30],"and":[31,38,41,66,129,174,183,208],"II)":[32],"each":[33,130],"comprising":[34],"six":[35],"transmembrane":[36,89,114,123,133,163,171,195],"regions":[37,90,124,134,164,172],"pore,":[40],"connecting":[43],"loop;":[45],"however,":[46,116],"little":[47],"is":[48],"known":[49],"concerning":[50],"how":[51],"these":[52],"channels":[53],"are":[54,71,96],"assembled.":[55],"In":[56],"present":[58,198],"paper,":[59],"we":[60],"report":[61],"that":[62],"both":[63,181],"domain":[64,92,136,155],"I":[65,93],"II":[67],"human":[69],"capable":[72,98,139],"independent":[74],"insertion":[75,207],"into":[76,204],"membranes,":[77],"whereas":[78,170],"loop":[80],"linking":[81],"fails":[84],"to":[85],"insert.":[86],"Pairs":[87],"within":[91,135],"TPC1":[95,166],"also":[97,167],"insertion,":[100],"consistent":[101],"with":[102],"sequential":[103],"translational":[104],"integration":[105],"regions.":[108,196],"Insertion":[109],"first":[112,161],"regions,":[115],"was":[117],"inefficient,":[118],"indicating":[119],"possible":[120],"interaction":[121],"between":[122,194],"during":[125],"translation.":[126],"Both":[127],"domains,":[128],"pair":[131],"I,":[137],"were":[138],"forming":[141],"oligomers,":[142],"highlighting":[143],"marked":[144],"redundancy":[145],"in":[146],"molecular":[148,202],"determinants":[149],"driving":[150],"oligomer":[151],"formation.":[152],"Each":[153],"formed":[156,168,180],"dimers":[157,182,190],"upon":[158],"cross-linking.":[159],"The":[160,197],"four":[162],"dimers,":[169],"5":[173],"6,":[175],"encompassing":[176],"pore":[178],"loop,":[179],"tetramers.":[184],"thus":[186],"probably":[187],"assemble":[188],"through":[191],"differential":[192],"interactions":[193],"study":[199],"provides":[200],"new":[201],"insight":[203],"membrane":[206],"oligomerization":[209],"TPCs.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
