{"id":"https://openalex.org/W2015328326","doi":"https://doi.org/10.1016/j.ijpharm.2012.10.044","title":"Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation","display_name":"Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation","publication_year":2012,"publication_date":"2012-11-08","ids":{"openalex":"https://openalex.org/W2015328326","doi":"https://doi.org/10.1016/j.ijpharm.2012.10.044","mag":"2015328326","pmid":"https://pubmed.ncbi.nlm.nih.gov/23142421"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2012.10.044","doi":"https://doi.org/10.1016/j.ijpharm.2012.10.044","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2012.10.044","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102808024","display_name":"Ju-Hwan Park","orcid":"https://orcid.org/0000-0001-8338-5708","observed_orcids":["https://orcid.org/0000-0001-8338-5708"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju-Hwan Park","raw_affiliation_strings":["National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022053152","display_name":"Hyo\u2010Eon Jin","orcid":"https://orcid.org/0000-0002-1292-5508","observed_orcids":["https://orcid.org/0000-0002-1292-5508"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyo-Eon Jin","raw_affiliation_strings":["National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078895940","display_name":"Dae\u2010Duk Kim","orcid":"https://orcid.org/0000-0003-0093-3874","observed_orcids":["https://orcid.org/0000-0003-0093-3874"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Duk Kim","raw_affiliation_strings":["National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012894904","display_name":"Suk\u2010Jae Chung","orcid":"https://orcid.org/0000-0001-8576-8470","observed_orcids":["https://orcid.org/0000-0001-8576-8470"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suk-Jae Chung","raw_affiliation_strings":["National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039386992","display_name":"Won\u2010Sik Shim","orcid":"https://orcid.org/0000-0002-1020-685X","observed_orcids":["https://orcid.org/0000-0002-1020-685X"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Won-Sik Shim","raw_affiliation_strings":["College of Pharmacy, Gachon University, Hambakmoeiro 191, Yeonsu-gu, Incheon 406-799, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Gachon University, Hambakmoeiro 191, Yeonsu-gu, Incheon 406-799, Republic of Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091547688","display_name":"Chang\u2010Koo Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Chang-Koo Shim","raw_affiliation_strings":["National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039386992","https://openalex.org/A5091547688"],"corresponding_institution_ids":["https://openalex.org/I12832649","https://openalex.org/I139264467"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":2.9399,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.9098179,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"441","issue":"1-2","first_page":"562","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan-microparticles","display_name":"chitosan microspheres","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ofloxacin","display_name":"ofloxacin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pulmonary-drug-delivery","display_name":"pulmonary drug delivery","score":0.8059999942779541},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.9459999799728394},{"id":"https://openalex.org/keywords/water-in-oil-emulsification","display_name":"water-in-oil emulsification","score":0.9340000152587891},{"id":"https://openalex.org/keywords/macrophage-uptake","display_name":"macrophage uptake","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nr8383-cells","display_name":"NR8383 cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2778049240","wikidata":"https://www.wikidata.org/wiki/Q411447","display_name":"Ofloxacin","level":4,"score":0.9723455905914307},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.7744500041007996},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5423892140388489},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.5056993961334229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.491129606962204},{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.481444776058197},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.46736857295036316},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.46245551109313965},{"id":"https://openalex.org/C82085835","wikidata":"https://www.wikidata.org/wiki/Q16142045","display_name":"Aerosolization","level":3,"score":0.4397948086261749},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.42448610067367554},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.41425517201423645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3745650351047516},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.31554439663887024},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.2999878525733948},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28195711970329285},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.279498815536499},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.21848708391189575},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18883636593818665},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.17153191566467285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06865891814231873},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005976","descriptor_name":"Glutaral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015242","descriptor_name":"Ofloxacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015242","descriptor_name":"Ofloxacin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ijpharm.2012.10.044","doi":"https://doi.org/10.1016/j.ijpharm.2012.10.044","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2012.10.044","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:23142421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23142421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Comparative Study"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/224221","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/224221","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1540100255","https://openalex.org/W1932693184","https://openalex.org/W1964163557","https://openalex.org/W1977149116","https://openalex.org/W1982627897","https://openalex.org/W1984360046","https://openalex.org/W1988207012","https://openalex.org/W1992153043","https://openalex.org/W1997409302","https://openalex.org/W2011818678","https://openalex.org/W2016198702","https://openalex.org/W2034737778","https://openalex.org/W2037699568","https://openalex.org/W2043598462","https://openalex.org/W2044872933","https://openalex.org/W2048274021","https://openalex.org/W2061077667","https://openalex.org/W2062342035","https://openalex.org/W2068846148","https://openalex.org/W2069442723","https://openalex.org/W2069782044","https://openalex.org/W2070298713","https://openalex.org/W2086614821","https://openalex.org/W2089602976","https://openalex.org/W2092810452","https://openalex.org/W2093377232","https://openalex.org/W2095892875","https://openalex.org/W2139001148","https://openalex.org/W2141629755","https://openalex.org/W2147445933","https://openalex.org/W2149860604","https://openalex.org/W2167774711","https://openalex.org/W2170563097","https://openalex.org/W2239384431","https://openalex.org/W2308938068","https://openalex.org/W2328349441","https://openalex.org/W2403894851","https://openalex.org/W2556873660","https://openalex.org/W3005484639","https://openalex.org/W4243233769","https://openalex.org/W6682100529"],"related_works":["https://openalex.org/W2070298713","https://openalex.org/W3118379174","https://openalex.org/W7001179950","https://openalex.org/W2139231653","https://openalex.org/W301527467","https://openalex.org/W2938438194","https://openalex.org/W2103177915","https://openalex.org/W4225275807","https://openalex.org/W6980545157","https://openalex.org/W2995515671"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
