{"id":"https://openalex.org/W2015326068","doi":"https://doi.org/10.1097/meg.0b013e3283352cbb","title":"COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention","display_name":"COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention","publication_year":2010,"publication_date":"2010-03-18","ids":{"openalex":"https://openalex.org/W2015326068","doi":"https://doi.org/10.1097/meg.0b013e3283352cbb","mag":"2015326068","pmid":"https://pubmed.ncbi.nlm.nih.gov/20075740"},"language":"en","primary_location":{"id":"doi:10.1097/meg.0b013e3283352cbb","doi":"https://doi.org/10.1097/meg.0b013e3283352cbb","is_oa":false,"landing_page_url":"https://doi.org/10.1097/meg.0b013e3283352cbb","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology & Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107479026","display_name":"Carina Pereira","orcid":"https://orcid.org/0000-0003-4302-2501","observed_orcids":["https://orcid.org/0000-0003-4302-2501"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carina Pereira","raw_affiliation_strings":["Portuguese Institute of Oncology, Porto, Portugal. anacmpereira@gmail.com","Portuguese Institute of Oncology, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portuguese Institute of Oncology, Porto, Portugal. anacmpereira@gmail.com","institution_ids":["https://openalex.org/I4210111164"]},{"raw_affiliation_string":"Portuguese Institute of Oncology, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084301295","display_name":"Pedro Pimentel\u2010Nunes","orcid":"https://orcid.org/0000-0002-7308-3295","observed_orcids":["https://orcid.org/0000-0002-7308-3295"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Pimentel-Nunes","raw_affiliation_strings":["Gastroenterology Department, Portuguese Institute of Oncology","Physiology Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department, Portuguese Institute of Oncology","institution_ids":["https://openalex.org/I4210103180"]},{"raw_affiliation_string":"Physiology Department","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Catarina Brand\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Brand\u00e3o","raw_affiliation_strings":["Gastroenterology Department, Portuguese Institute of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department, Portuguese Institute of Oncology","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024968221","display_name":"Lu\u00eds Moreira\u2010Dias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Moreira-Dias","raw_affiliation_strings":["Gastroenterology Department, Portuguese Institute of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department, Portuguese Institute of Oncology","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002735203","display_name":"Rui Medeiros","orcid":"https://orcid.org/0000-0003-3010-8373","observed_orcids":["https://orcid.org/0000-0003-3010-8373"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Medeiros","raw_affiliation_strings":["ICBAS, Abel Salazar Institute for the Biomedical Sciences, University of Porto, Port, Portugal","Molecular Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICBAS, Abel Salazar Institute for the Biomedical Sciences, University of Porto, Port, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]},{"raw_affiliation_string":"Molecular Oncology Group","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014360454","display_name":"M\u00e1rio Jorge Dinis-Ribeiro","orcid":"https://orcid.org/0000-0003-0121-6850","observed_orcids":["https://orcid.org/0000-0003-0121-6850"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]},{"id":"https://openalex.org/I4210137384","display_name":"Centre for Health Technology and Services Research","ror":"https://ror.org/0434vme59","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210137384"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M\u00e1rio Dinis-Ribeiro","raw_affiliation_strings":["CINTESIS/Department of Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto","Gastroenterology Department, Portuguese Institute of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINTESIS/Department of Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210137384"]},{"raw_affiliation_string":"Gastroenterology Department, Portuguese Institute of Oncology","institution_ids":["https://openalex.org/I4210103180"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8133,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.94969059,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"5","first_page":"607","last_page":"613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8379999995231628},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9179999828338623},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7770000100135803},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8920000195503235},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.777999997138977},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.806627094745636},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7974666953086853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7891502380371094},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7463524341583252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6784875392913818},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6330593824386597},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.593087375164032},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5368211269378662},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.529099702835083},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4628182649612427},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4264051020145416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36683979630470276},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32515841722488403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2627817988395691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13579437136650085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12500202655792236}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/meg.0b013e3283352cbb","doi":"https://doi.org/10.1097/meg.0b013e3283352cbb","is_oa":false,"landing_page_url":"https://doi.org/10.1097/meg.0b013e3283352cbb","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology & Hepatology","raw_type":"journal-article"},{"id":"pmid:20075740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20075740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1523805774","https://openalex.org/W1648593433","https://openalex.org/W1971160226","https://openalex.org/W1972504351","https://openalex.org/W1975076018","https://openalex.org/W1976415203","https://openalex.org/W1980858407","https://openalex.org/W1983264604","https://openalex.org/W1985046539","https://openalex.org/W1992991089","https://openalex.org/W2004957314","https://openalex.org/W2029161817","https://openalex.org/W2037952228","https://openalex.org/W2038301005","https://openalex.org/W2052572594","https://openalex.org/W2053143976","https://openalex.org/W2054872303","https://openalex.org/W2062406653","https://openalex.org/W2079290729","https://openalex.org/W2084863173","https://openalex.org/W2097903769","https://openalex.org/W2118538747","https://openalex.org/W2124567477","https://openalex.org/W2130418564","https://openalex.org/W2130833596","https://openalex.org/W2137520566","https://openalex.org/W2147618020","https://openalex.org/W2147828056","https://openalex.org/W2159874711","https://openalex.org/W2164597973","https://openalex.org/W2171165592","https://openalex.org/W2391019246","https://openalex.org/W2410622758","https://openalex.org/W2594842159","https://openalex.org/W4211090034","https://openalex.org/W6663587680","https://openalex.org/W6711756277"],"related_works":["https://openalex.org/W2557753004","https://openalex.org/W2105239364","https://openalex.org/W2130418564","https://openalex.org/W2036894983","https://openalex.org/W2391990365","https://openalex.org/W1994383673","https://openalex.org/W2600139594","https://openalex.org/W2133383641","https://openalex.org/W4320888321","https://openalex.org/W2131088390"],"abstract_inverted_index":{"OBJECTIVE:":[0],"COX-2,":[1],"the":[2,28,49,175,185,197,216,223,235],"inducible":[3],"isoenzyme,":[4],"was":[5,108,178],"found":[6],"to":[7,17,36,47,115,160,195],"be":[8,34],"overexpressed":[9],"in":[10,20,59,174,204,228],"approximately":[11],"85%":[12],"of":[13,30,51,87,225],"colorectal":[14,60],"adenocarcinomas,":[15],"contributing":[16],"key":[18],"steps":[19],"tumor":[21],"development.":[22],"COX-2":[23,53,90,192,226],"polymorphisms":[24,54],"that":[25,230],"might":[26],"modify":[27],"levels":[29],"protein":[31],"expression":[32],"would":[33],"anticipated":[35],"have":[37,161],"a":[38,69,111,119,162],"substantial":[39],"influence":[40],"on":[41],"disease":[42],"phenotype.":[43],"Therefore,":[44],"we":[45],"sought":[46],"understand":[48],"role":[50],"three":[52],"(-1195A>G,":[55],"-765G>C,":[56],"and":[57,79,123,143,182,220,238],"8473T>C)":[58],"cancer":[61],"(CRC)":[62],"onset.":[63,117],"MATERIAL":[64],"AND":[65],"METHODS:":[66],"We":[67],"conducted":[68],"hospital-based":[70],"case-control":[71],"study":[72],"involving":[73],"117":[74],"consecutively":[75],"enrolled":[76],"CRC":[77,116,134,167,201],"patients":[78],"256":[80],"healthy":[81],"individuals":[82],"without":[83],"any":[84],"clinical":[85],"evidence":[86],"cancer.":[88],"The":[89,105,190],"polymorphisms'":[91],"genotypes":[92],"were":[93],"characterized":[94],"by":[95,234],"PCR-restriction":[96],"fragment":[97],"length":[98],"polymorphism":[99,107,193],"or":[100],"real-time":[101],"PCR":[102],"techniques.":[103],"RESULTS:":[104],"-1195A>G":[106,191],"associated":[109],"with":[110],"1.73-fold":[112],"increased":[113,131,164],"predisposition":[114],"In":[118],"stratified":[120],"analysis,":[121],"men":[122,154,205],"ever-smokers":[124,155],"carrying":[125,156],"-1195G":[126,157],"allele":[127,158],"(AG+GG)":[128],"had":[129],"an":[130],"risk":[132,165,219],"for":[133,166,184,200,222],"development":[135],"(odds":[136],"ratio:":[137,145],"2.58;":[138],"95%":[139,147],"confidence":[140,148],"intraval:":[141,149],"1.29-5.15":[142],"odds":[144],"10.3;":[146],"3.37-31.2,":[150],"respectively).":[151],"More":[152],"interestingly,":[153],"appeared":[159],"nine-fold":[163],"onset":[168],"(95%":[169],"CI:":[170],"2.94-27.6).":[171],"No":[172],"difference":[173],"genotype's":[176],"distribution":[177],"noticed":[179],"between":[180,218],"cases":[181],"controls":[183],"remaining":[186],"two":[187],"polymorphisms.":[188],"CONCLUSION:":[189],"seems":[194],"modulate":[196],"genetic":[198],"susceptibility":[199],"onset,":[202],"especially":[203],"ever-smokers.":[206],"This":[207],"genetically":[208],"based":[209],"higher-risk":[210],"group":[211],"definition":[212],"may":[213],"help":[214],"shift":[215],"balance":[217],"benefits":[221],"use":[224],"inhibitors":[227],"chemoprevention":[229],"is":[231],"currently":[232],"hampered":[233],"adverse":[236],"gastrointestinal":[237],"cardiovascular":[239],"side-effects.":[240]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}