{"id":"https://openalex.org/W2015317431","doi":"https://doi.org/10.1111/j.1530-0277.1990.tb00508.x","title":"Behavioral and Subjective Effects of Ethanol: Relationship to Cerebral Metabolism Using PET","display_name":"Behavioral and Subjective Effects of Ethanol: Relationship to Cerebral Metabolism Using PET","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W2015317431","doi":"https://doi.org/10.1111/j.1530-0277.1990.tb00508.x","mag":"2015317431","pmid":"https://pubmed.ncbi.nlm.nih.gov/2198826"},"language":"en","primary_location":{"id":"doi:10.1111/j.1530-0277.1990.tb00508.x","doi":"https://doi.org/10.1111/j.1530-0277.1990.tb00508.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1990.tb00508.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041945807","display_name":"Harriet de Wit","orcid":"https://orcid.org/0000-0002-7211-8994","observed_orcids":["https://orcid.org/0000-0002-7211-8994"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. de Wit","raw_affiliation_strings":["Department of Psychiatry, University of Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863850","display_name":"John T. Metz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Metz","raw_affiliation_strings":["Department of Psychiatry, the Department of Radiology, and the Illinois State Psychiatric Institute, University of Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, the Department of Radiology, and the Illinois State Psychiatric Institute, University of Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Wagner","raw_affiliation_strings":["Department of Psychiatry, the Department of Radiology, and the Illinois State Psychiatric Institute, University of Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, the Department of Radiology, and the Illinois State Psychiatric Institute, University of Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112084236","display_name":"Malcolm Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Cooper","raw_affiliation_strings":["Department of Psychiatry, the Department of Radiology, and the Illinois State Psychiatric Institute, University of Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, the Department of Radiology, and the Illinois State Psychiatric Institute, University of Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041945807"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":3.7805,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.93055415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"482","last_page":"489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.24719999730587006,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.8169999718666077},{"id":"https://openalex.org/keywords/subjective-effects-of-alcohol","display_name":"subjective effects of alcohol","score":0.6899999976158142},{"id":"https://openalex.org/keywords/positive-mood","display_name":"positive mood","score":0.574999988079071},{"id":"https://openalex.org/keywords/behavioral-preferences","display_name":"behavioral preferences","score":0.4429999887943268},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6593260765075684},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.6348440051078796},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5297264456748962},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4601171314716339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3981792628765106},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3728911876678467},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3413562774658203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3308093249797821},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21305018663406372},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.19255566596984863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10731041431427002},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08820199966430664},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000339","descriptor_name":"Affect","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010556","descriptor_name":"Personality Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1530-0277.1990.tb00508.x","doi":"https://doi.org/10.1111/j.1530-0277.1990.tb00508.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1990.tb00508.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:2198826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2198826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G456316537","display_name":null,"funder_award_id":"DA 02812","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7629899948","display_name":"General Clinical Research Center","funder_award_id":"M01RR000055","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8310491216","display_name":"Determinants of Drug Preference in Humans","funder_award_id":"R01DA002812","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1951442280","https://openalex.org/W1981288172","https://openalex.org/W1998959746","https://openalex.org/W2007856779","https://openalex.org/W2020756846","https://openalex.org/W2029181187","https://openalex.org/W2031235671","https://openalex.org/W2040926452","https://openalex.org/W2045075681","https://openalex.org/W2061161259","https://openalex.org/W2062398979","https://openalex.org/W2081300445","https://openalex.org/W2086918894","https://openalex.org/W2090203522","https://openalex.org/W2110965393","https://openalex.org/W2114963277","https://openalex.org/W2486330806","https://openalex.org/W4293858637"],"related_works":["https://openalex.org/W2054081060","https://openalex.org/W2397792038","https://openalex.org/W2082429473","https://openalex.org/W2064814535","https://openalex.org/W1978687964","https://openalex.org/W1971631607","https://openalex.org/W2053623278","https://openalex.org/W38005040","https://openalex.org/W2092411360","https://openalex.org/W2797182873"],"abstract_inverted_index":{"This":[0],"study":[1,18],"examined":[2],"the":[3,20,23,43,47,49,110,121,124,128,137,140,181,205],"effects":[4,25,30,114,133,155,207],"of":[5,26,46,115,127,151,186,208],"ethanol":[6,27,67,116,152,174,187,209],"on":[7,31,134,156],"regional":[8,32,160,170,218],"cerebral":[9,33],"metabolic":[10,171],"rate":[11],"using":[12,102],"positron":[13],"emission":[14],"tomography":[15],"(PET).":[16],"The":[17,112,148,183],"explored":[19],"relationship":[21],"between":[22],"mood-altering":[24,113,206],"and":[28,123,139,159],"its":[29],"glucose":[34],"utilization":[35],"(CMRglu)":[36],"in":[37,52,58,70,77,88,119,136,145,192,213,220],"eight":[38],"healthy":[39],"male":[40],"volunteers.":[41],"In":[42],"first":[44],"phase":[45],"study,":[48],"subjects":[50],"participated":[51,76],"a":[53,59,71,103,214],"behavioral":[54],"preference":[55],"procedure":[56],"conducted":[57,101],"recreational":[60],"environment":[61],"to":[62,66,84,180,217],"determine":[63],"their":[64],"responses":[65,179],"(0.5":[68],"g/kg)":[69],"naturalistic":[72,122,138],"setting.":[73],"They":[74],"then":[75],"three":[78,83],"PET":[79,98,125,141],"sessions,":[80],"receiving":[81],"at":[82],"seven":[85],"day":[86],"intervals,":[87],"counterbalanced":[89],"order,":[90],"placebo,":[91],"0.5":[92],"g/kg":[93,96],"or":[94],"0.8":[95],"ethanol.":[97],"scans":[99],"were":[100,117,175,197],"PETT-VI":[104],"scanner":[105],"with":[106,177],"F-18-2-fluoro-2-deoxyglucose":[107],"(FDG)":[108],"as":[109],"tracer.":[111],"measured":[118],"both":[120],"phases":[126],"study.":[129],"Ethanol":[130],"produced":[131,153],"comparable":[132],"mood":[135],"settings":[142],"(i.e.,":[143],"increases":[144],"positive":[146],"mood).":[147],"lower":[149],"dose":[150,185],"variable":[154],"whole":[157,189],"brain":[158,190],"CMRglu":[161,191],"across":[162],"subjects.":[163,194],"There":[164],"was":[165,202],"some":[166],"suggestion":[167],"that":[168,204],"certain":[169],"changes":[172,219],"after":[173],"correlated":[176],"subjective":[178],"drug.":[182],"higher":[184],"decreased":[188],"most":[193],"All":[195],"regions":[196],"affected":[198],"about":[199],"equally.":[200],"It":[201],"concluded":[203],"are":[210],"not":[211],"related":[212],"simple":[215],"manner":[216],"CMRglu.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}