{"id":"https://openalex.org/W2015316294","doi":"https://doi.org/10.1016/j.jalz.2008.05.1450","title":"P2\u2010372: Development of oligomer\u2010specific alpha\u2010synuclein antibodies","display_name":"P2\u2010372: Development of oligomer\u2010specific alpha\u2010synuclein antibodies","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W2015316294","doi":"https://doi.org/10.1016/j.jalz.2008.05.1450","mag":"2015316294"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2008.05.1450","doi":"https://doi.org/10.1016/j.jalz.2008.05.1450","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2008.05.1450","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088664019","display_name":"Therese Wahlberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Therese Wahlberg","raw_affiliation_strings":["Public Health and Caring Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health and Caring Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003893889","display_name":"Tomas N\u00e4sstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tomas N\u00e4sstr\u00f6m","raw_affiliation_strings":["Public Health and Caring Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health and Caring Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113902232","display_name":"Marie Hedlund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marie Hedlund","raw_affiliation_strings":["Public Health and Caring Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health and Caring Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029284586","display_name":"Frida Ekholm Pettersson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Frida Ekholm Pettersson","raw_affiliation_strings":["Public Health and Caring Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health and Caring Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018345023","display_name":"Lars Lannfelt","orcid":"https://orcid.org/0000-0001-9839-659X","observed_orcids":["https://orcid.org/0000-0001-9839-659X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars Lannfelt","raw_affiliation_strings":["Public Health and Caring Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health and Caring Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005585024","display_name":"Martin Ingelsson","orcid":"https://orcid.org/0000-0001-5466-8370","observed_orcids":["https://orcid.org/0000-0001-5466-8370"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Martin Ingelsson","raw_affiliation_strings":["Public Health and Caring Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health and Caring Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016812105","display_name":"Joakim J. E. Bergstr\u00f6m","orcid":"https://orcid.org/0000-0002-9700-5419","observed_orcids":["https://orcid.org/0000-0002-9700-5419"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Joakim Bergstr\u00f6m","raw_affiliation_strings":["Public Health and Caring Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health and Caring Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088664019"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"4S_Part_14","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/oligomeric-alpha-synuclein","display_name":"oligomeric alpha-synuclein","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7548493146896362},{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.7229655981063843},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6508461833000183},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.6508023738861084},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.6502953171730042},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.513116180896759},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5018010139465332},{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.4861266613006592},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44125962257385254},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.43994003534317017},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.42840132117271423},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4137864112854004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36355000734329224},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3397884666919708},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2870228886604309},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2826150059700012},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.232923686504364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22613811492919922},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.1765347421169281},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16377049684524536},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1407606303691864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2008.05.1450","doi":"https://doi.org/10.1016/j.jalz.2008.05.1450","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2008.05.1450","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1661957452","https://openalex.org/W1975638928","https://openalex.org/W3088641381","https://openalex.org/W2025829713","https://openalex.org/W3034385109","https://openalex.org/W2909238401","https://openalex.org/W4389447584","https://openalex.org/W6947965843","https://openalex.org/W4294989680","https://openalex.org/W2043885531"],"abstract_inverted_index":{"Aggregates":[0],"of":[1,15,37,84,95,132,163,166,196,216],"alpha-synuclein":[2],"(a-syn)":[3],"are":[4,42,219],"present":[5],"as":[6,60],"Lewy":[7,10,21],"bodies":[8,22],"and":[9,24,67,81,86,148,153,182,214],"neurites":[11],"in":[12,48,159],"the":[13,38,46,114,127,146,167],"brains":[14],"patients":[16],"suffering":[17],"from":[18],"dementia":[19],"with":[20,70,93,104,138,192],"(DLB)":[23],"Parkinson\u2032s":[25],"disease":[26],"(PD).":[27],"Accumulating":[28],"evidence":[29],"suggests":[30],"that":[31,203],"oligomers,":[32],"intermediately":[33],"sized":[34],"soluble":[35],"species":[36],"a-syn":[39,71,122,140,155,172,180,197,210],"aggregation":[40],"process,":[41],"primarily":[43],"responsible":[44],"for":[45,62,78,82,121,179],"neurotoxicity":[47],"these":[49,217],"disorders.":[50],"Our":[51],"aim":[52],"is":[53],"to":[54,108,126,145,171,209],"develop":[55],"oligomer":[56,198],"specific":[57,208],"monoclonal":[58],"antibodies":[59,74,123,149,207,218],"tools":[61],"studies":[63],"on":[64],"cell":[65],"cultures":[66],"transgenic":[68],"mice":[69,134,143],"pathology.":[72],"Such":[73],"might":[75],"be":[76],"useful":[77],"diagnostic":[79],"purposes":[80],"immunotherapy":[83],"DLB":[85],"PD.":[87],"Mice":[88],"were":[89,102,117,136,157,176],"repeatedly":[90],"immunized":[91,137],"subcutaneously":[92],"preparations":[94],"oligomeric":[96,128,139,152],"recombinant":[97],"a-syn.":[98],"Next,":[99],"spleen":[100],"cells":[101,107],"fused":[103],"mouse":[105],"myeloma":[106],"generate":[109],"antibody":[110],"producing":[111],"hybridomas.":[112],"Finally,":[113],"generated":[115,206],"clones":[116,168,191],"screened,":[118],"using":[119],"ELISA,":[120],"specifically":[124],"binding":[125],"state.":[129],"A":[130],"total":[131],"five":[133],"(Balb/c)":[135],"preparations.":[141],"All":[142],"responded":[144],"immunization":[147],"against":[150],"monomeric,":[151],"fibrillar":[154],"forms":[156],"detected":[158],"plasma.":[160],"After":[161],"generation":[162],"hybridomas,":[164],"some":[165],"showed":[169],"specificity":[170],"oligomers":[173],"whereas":[174],"others":[175],"more":[177],"selective":[178],"monomers":[181],"fibrils.":[183],"Ongoing":[184],"subcloning":[185],"aims":[186],"at":[187],"further":[188],"isolating":[189],"IgG-positive":[190],"a":[193],"high":[194],"degree":[195],"specificity.":[199],"Preliminary":[200],"results":[201],"indicate":[202],"we":[204],"have":[205],"oligomers.":[211],"Further":[212],"screening":[213],"characterization":[215],"ongoing.":[220]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
