{"id":"https://openalex.org/W2015312171","doi":"https://doi.org/10.1152/jn.00781.2001","title":"Role of Dendritic Spines in Action Potential Backpropagation: A Numerical Simulation Study","display_name":"Role of Dendritic Spines in Action Potential Backpropagation: A Numerical Simulation Study","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2015312171","doi":"https://doi.org/10.1152/jn.00781.2001","mag":"2015312171","pmid":"https://pubmed.ncbi.nlm.nih.gov/12424316"},"language":"en","primary_location":{"id":"doi:10.1152/jn.00781.2001","doi":"https://doi.org/10.1152/jn.00781.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00781.2001","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111620771","display_name":"David Tsay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Tsay","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, New York 10027","Department of Biological Sciences, Columbia University, New York, New York 10027, USA. dt133@columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, New York 10027","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, New York 10027, USA. dt133@columbia.edu","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083888813","display_name":"Rafael Yuste","orcid":"https://orcid.org/0000-0003-4206-497X","observed_orcids":["https://orcid.org/0000-0003-4206-497X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael Yuste","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, New York 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, New York 10027","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.5117,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.53697248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"88","issue":"5","first_page":"2834","last_page":"2845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.15870000422000885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.996999979019165},{"id":"https://openalex.org/keywords/action-potential-backpropagation","display_name":"action potential backpropagation","score":0.996999979019165},{"id":"https://openalex.org/keywords/sodium-channel-density","display_name":"sodium channel density","score":0.734000027179718},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.777999997138977},{"id":"https://openalex.org/keywords/dendritic-signaling","display_name":"dendritic signaling","score":0.7099999785423279},{"id":"https://openalex.org/keywords/sodium-channel-clustering","display_name":"sodium channel clustering","score":0.652999997138977},{"id":"https://openalex.org/keywords/spine-morphology","display_name":"dendritic spine morphology","score":0.859000027179718},{"id":"https://openalex.org/keywords/apical-dendrites","display_name":"apical dendrites","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.9118444919586182},{"id":"https://openalex.org/C155032097","wikidata":"https://www.wikidata.org/wiki/Q798503","display_name":"Backpropagation","level":3,"score":0.7930730581283569},{"id":"https://openalex.org/C205383261","wikidata":"https://www.wikidata.org/wiki/Q7392570","display_name":"SPINE (molecular biology)","level":2,"score":0.6820465922355652},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6313961148262024},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.6257067918777466},{"id":"https://openalex.org/C50820595","wikidata":"https://www.wikidata.org/wiki/Q5256675","display_name":"Dendritic spike","level":4,"score":0.5917186141014099},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3995150923728943},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3829995095729828},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.335040807723999},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2884811758995056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2483910322189331},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.2290762960910797},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14496952295303345},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.07469549775123596},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.06628352403640747},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jn.00781.2001","doi":"https://doi.org/10.1152/jn.00781.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00781.2001","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmid:12424316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12424316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2690882572","display_name":"SPINE MOTILITY AND VISUAL PLASTICITY","funder_award_id":"R01EY013237","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8371192985","display_name":"IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX","funder_award_id":"R01NS040726","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1528942588","https://openalex.org/W1549050411","https://openalex.org/W1566861944","https://openalex.org/W1568625389","https://openalex.org/W1572640432","https://openalex.org/W1574935607","https://openalex.org/W1677457722","https://openalex.org/W1716632673","https://openalex.org/W1763296052","https://openalex.org/W1775494655","https://openalex.org/W1783167916","https://openalex.org/W1828412953","https://openalex.org/W1852715831","https://openalex.org/W1971366695","https://openalex.org/W1971405760","https://openalex.org/W1972289901","https://openalex.org/W1972815737","https://openalex.org/W1973816298","https://openalex.org/W1979356066","https://openalex.org/W1980618916","https://openalex.org/W1986246844","https://openalex.org/W1997220636","https://openalex.org/W2004921550","https://openalex.org/W2007289876","https://openalex.org/W2015399184","https://openalex.org/W2016582329","https://openalex.org/W2016999231","https://openalex.org/W2022802465","https://openalex.org/W2028055236","https://openalex.org/W2030739138","https://openalex.org/W2033087539","https://openalex.org/W2042457404","https://openalex.org/W2044833738","https://openalex.org/W2046503384","https://openalex.org/W2048088781","https://openalex.org/W2049699715","https://openalex.org/W2050566796","https://openalex.org/W2055568369","https://openalex.org/W2057426891","https://openalex.org/W2059256607","https://openalex.org/W2062148835","https://openalex.org/W2062820369","https://openalex.org/W2063027609","https://openalex.org/W2065416066","https://openalex.org/W2066002146","https://openalex.org/W2072233684","https://openalex.org/W2073818625","https://openalex.org/W2081940193","https://openalex.org/W2084518163","https://openalex.org/W2096424464","https://openalex.org/W2099676980","https://openalex.org/W2101473364","https://openalex.org/W2106235427","https://openalex.org/W2109889898","https://openalex.org/W2110887671","https://openalex.org/W2111916392","https://openalex.org/W2113617205","https://openalex.org/W2117120818","https://openalex.org/W2131441488","https://openalex.org/W2133406691","https://openalex.org/W2134937647","https://openalex.org/W2145296723","https://openalex.org/W2152016695","https://openalex.org/W2156941468","https://openalex.org/W2165375369","https://openalex.org/W2185212694","https://openalex.org/W2200411430","https://openalex.org/W2220761031","https://openalex.org/W2233298138","https://openalex.org/W2414649194","https://openalex.org/W2471521183","https://openalex.org/W4234546939","https://openalex.org/W4293029111"],"related_works":["https://openalex.org/W2099676980","https://openalex.org/W24027051","https://openalex.org/W4407121609","https://openalex.org/W2059256607","https://openalex.org/W2613002003","https://openalex.org/W3163239097","https://openalex.org/W2145198020","https://openalex.org/W2033379301","https://openalex.org/W2188502712","https://openalex.org/W2152003243"],"abstract_inverted_index":{"Two":[0],"remarkable":[1],"aspects":[2],"of":[3,15,23,30,41,65,84,86,95,141],"pyramidal":[4],"neurons":[5],"are":[6,20],"their":[7,149,153],"complex":[8],"dendritic":[9,32,45,71,99,132],"morphologies":[10],"and":[11,47,74,82],"the":[12,21,27,31,39,63,80,131],"abundant":[13],"presence":[14],"spines,":[16],"small":[17],"structures":[18],"that":[19,92,119,159],"sites":[22],"excitatory":[24],"input.":[25],"Although":[26],"channel":[28,72],"properties":[29,43],"shaft":[33,133],"membrane":[34],"have":[35,57],"been":[36],"experimentally":[37],"probed,":[38],"influence":[40,85,165],"spine":[42,162],"in":[44,98,106,122,130,144,161],"signaling":[46],"action":[48],"potential":[49,117],"propagation":[50],"remains":[51],"unclear.":[52],"To":[53],"explore":[54],"this":[55],"we":[56,157],"performed":[58],"multi-compartmental":[59],"numerical":[60],"simulations":[61],"investigating":[62],"degree":[64,83],"consistency":[66],"between":[67],"experimental":[68],"data":[69],"on":[70],"densities":[73,94,126],"backpropagation":[75,104,166],"behavior,":[76],"as":[77,79,115],"well":[78],"necessity":[81],"excitable":[87],"spines.":[88],"Our":[89],"results":[90,169],"indicate":[91],"measured":[93,129],"Na(+)":[96,120,142],"channels":[97,121,143],"shafts":[100],"cannot":[101],"support":[102,135],"effective":[103],"observed":[105],"apical":[107],"dendrites":[108],"due":[109,151],"to":[110,147,152,179],"suprathreshold":[111],"inactivation.":[112],"We":[113],"demonstrate":[114],"a":[116],"solution":[118],"spines":[123,145,176],"at":[124],"higher":[125],"than":[127],"those":[128],"can":[134],"extensive":[136],"backpropagation.":[137,181],"In":[138],"addition,":[139],"clustering":[140,173],"appears":[146],"enhance":[148],"effect":[150],"unique":[154],"morphology.":[155],"Finally,":[156],"show":[158],"changes":[160],"morphology":[163],"significantly":[164],"efficacy.":[167],"These":[168],"suggest":[170],"that,":[171],"by":[172],"sodium":[174],"channels,":[175],"may":[177],"serve":[178],"control":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}