{"id":"https://openalex.org/W2015305669","doi":"https://doi.org/10.1055/s-0032-1314858","title":"The Effect of Vitamin D on Expression of TGF \u03b21 in Ovary","display_name":"The Effect of Vitamin D on Expression of TGF \u03b21 in Ovary","publication_year":2012,"publication_date":"2012-07-31","ids":{"openalex":"https://openalex.org/W2015305669","doi":"https://doi.org/10.1055/s-0032-1314858","mag":"2015305669","pmid":"https://pubmed.ncbi.nlm.nih.gov/22851187"},"language":"en","primary_location":{"id":"doi:10.1055/s-0032-1314858","doi":"https://doi.org/10.1055/s-0032-1314858","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0032-1314858","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025492308","display_name":"Nerg\u00fcl \u00c7\u00f6rd\u00fck","orcid":"https://orcid.org/0009-0008-5102-8392","observed_orcids":["https://orcid.org/0009-0008-5102-8392"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"N. Corduk","raw_affiliation_strings":["Pediatric Surgery, Pamukkale University School of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Surgery, Pamukkale University School of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038100608","display_name":"G\u00fcl\u00e7in Abban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G. Abban","raw_affiliation_strings":["Histology and Embryology, Pamukkale University, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histology and Embryology, Pamukkale University, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Yildirim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B. Yildirim","raw_affiliation_strings":["Obstetrics and Gynecology, Pamukkale University School of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology, Pamukkale University School of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070162702","display_name":"Ak\u0131le Sar\u0131o\u011flu-B\u00fcke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"A. Sarioglu-Buke","raw_affiliation_strings":["Pediatric Surgery, Pamukkale University School of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Surgery, Pamukkale University School of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025492308"],"corresponding_institution_ids":["https://openalex.org/I48843708"],"apc_list":null,"apc_paid":null,"fwci":1.4929,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.79822107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"120","issue":"08","first_page":"494","last_page":"493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.17020000517368317,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9890000224113464},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8960000276565552},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7080000042915344},{"id":"https://openalex.org/keywords/ovarian-follicle-development","display_name":"ovarian follicle development","score":0.7979999780654907},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/oocytes","display_name":"oocytes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.5659999847412109},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.4830000102519989},{"id":"https://openalex.org/keywords/rat-ovary","display_name":"rat ovary","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.8683125972747803},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7698129415512085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7639784812927246},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.6667750477790833},{"id":"https://openalex.org/C5512455","wikidata":"https://www.wikidata.org/wiki/Q2142940","display_name":"Folliculogenesis","level":4,"score":0.6338209509849548},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5975688695907593},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5523508191108704},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.533478856086731},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.48951709270477295},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.47867971658706665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45125022530555725},{"id":"https://openalex.org/C2777203538","wikidata":"https://www.wikidata.org/wiki/Q1543282","display_name":"Granulosa cell","level":3,"score":0.4144967794418335},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32559239864349365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3026998043060303},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.08046957850456238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.061708271503448486},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009866","descriptor_name":"Oogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046468","descriptor_name":"Sexual Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0032-1314858","doi":"https://doi.org/10.1055/s-0032-1314858","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0032-1314858","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"},{"id":"pmid:22851187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22851187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3001417722","https://openalex.org/W2901217872","https://openalex.org/W2033457392","https://openalex.org/W3152357308","https://openalex.org/W3105426143","https://openalex.org/W2165975054","https://openalex.org/W4372346232","https://openalex.org/W2108471105","https://openalex.org/W3097546169","https://openalex.org/W4310770905"],"abstract_inverted_index":{"The":[0,29,250],"transforming":[1],"growth":[2],"factor":[3],"\u03b2":[4],"(TGF-\u03b2)":[5],"is":[6,19,242],"thought":[7],"to":[8,36,112],"have":[9],"important":[10],"roles":[11],"in":[12,21,48,67,141,150,162,176,183,187,205,208,211,222,227,262],"several":[13],"stages":[14],"of":[15,31,41,46,83,119,129,180,252],"folliculogenesis.":[16],"Vitamin":[17,245],"D":[18,202,239,246,258],"effective":[20],"cell":[22],"proliferation,":[23],"differentition":[24],"and":[25,57,79,88,115,121,133,144,153,178,192],"on":[26,44],"estrogen":[27],"biosynthesis.":[28],"aim":[30],"the":[32,38,212,223],"present":[33],"study":[34,254],"was":[35,107,158,169],"determine":[37],"respective":[39],"role":[40,261],"1,25-dihydroxyvitamin":[42],"D3":[43,101],"expression":[45,217],"TGF-\u03b21":[47,147,167,171,209,216,232,248],"developing":[49],"rat":[50],"ovaries.":[51],"24":[52],"(one-mounth-old":[53],"n":[54,59],"=":[55,60,86,92],"12":[56],"adult":[58,89,122,213],"12)":[61],"female":[62],"Wistar":[63],"rats":[64,90,123],"were":[65,72,131,148,173,194,234],"enrolled":[66],"this":[68,253],"study.":[69],"All":[70],"animals":[71,130],"divided":[73],"into":[74],"4":[75],"groups.":[76,98],"Group":[77],"I":[78,152],"II":[80],"that":[81,200,244,256],"consist":[82,118],"one-month-old":[84],"(n":[85,91],"6)":[87,93],"respectively":[94],"served":[95],"as":[96],"control":[97],"Intramuscular":[99],"vitamin":[100,201,238,257],"(":[102],"0,05":[103],"\u03bcgr/kg/every":[104],"other":[105],"day)":[106],"injected":[108],"for":[109,135,146,196],"8":[110],"weeks":[111],"group":[113,151,154,184,188],"III":[114],"IV":[116,189],"which":[117],"one-mounth-old":[120],"respectively.":[124],"After":[125],"last":[126],"injection,":[127],"ovaries":[128],"removed":[132],"processed":[134],"immunohistochemistry":[136],"assay.":[137],"No":[138],"remarkable":[139],"differences":[140],"staining":[142],"intensity":[143],"localization":[145],"observed":[149,174,243],"III.":[155],"TGF":[156],"immunostaining":[157,172],"also":[159],"predominantly":[160],"found":[161,199],"oocytes.":[163],"In":[164],"granulosa":[165,181,190],"cells,":[166],"immunoreactivity":[168],"negative.":[170],"both":[175],"nuclei":[177],"cytoplasm":[179],"cells":[182,191],"II.":[185],"But":[186],"oocytes":[193],"negative":[195],"TGF-\u03b21.":[197,265],"We":[198],"administration":[203],"resulted":[204],"a":[206],"decrease":[207,221],"levels":[210],"rats,":[214],"but,":[215],"did":[218],"not":[219],"significantly":[220],"newborn":[224],"rats.":[225],"However,":[226],"multiple":[228],"linear":[229],"regression":[230],"analysis,":[231],"expressions":[233],"independently":[235],"associated":[236],"with":[237],"administration.":[240],"It":[241],"attenuated":[247],"expression.":[249],"results":[251],"suggest":[255],"may":[259],"play":[260],"folliculogenesis":[263],"via":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}