{"id":"https://openalex.org/W2015288678","doi":"https://doi.org/10.1016/j.tox.2014.09.011","title":"\u03949-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPAR\u03b1 in MDA-MB-231 breast cancer cells","display_name":"\u03949-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPAR\u03b1 in MDA-MB-231 breast cancer cells","publication_year":2014,"publication_date":"2014-10-05","ids":{"openalex":"https://openalex.org/W2015288678","doi":"https://doi.org/10.1016/j.tox.2014.09.011","mag":"2015288678","pmid":"https://pubmed.ncbi.nlm.nih.gov/25291031","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4258431"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2014.09.011","doi":"https://doi.org/10.1016/j.tox.2014.09.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2014.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/abstract/MED/25291031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014577532","display_name":"Shuso Takeda","orcid":"https://orcid.org/0000-0003-2193-1421","observed_orcids":["https://orcid.org/0000-0003-2193-1421"]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]},{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuso Takeda","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan","Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan","institution_ids":["https://openalex.org/I2802008203","https://openalex.org/I4210131401"]},{"raw_affiliation_string":"Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046243330","display_name":"Eriko Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eriko Ikeda","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033494026","display_name":"Shengzhong Su","orcid":"https://orcid.org/0000-0002-3519-3899","observed_orcids":["https://orcid.org/0000-0002-3519-3899"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengzhong Su","raw_affiliation_strings":["Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111812802","display_name":"Mari Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mari Harada","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101728309","display_name":"Hiroyuki Okazaki","orcid":"https://orcid.org/0000-0002-4509-0228","observed_orcids":["https://orcid.org/0000-0002-4509-0228"]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Okazaki","raw_affiliation_strings":["Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4509-0228","affiliations":[{"raw_affiliation_string":"Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087533789","display_name":"Yasushi Yoshioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Yoshioka","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hajime Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Nishimura","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064928700","display_name":"Hiroyuki Ishii","orcid":"https://orcid.org/0000-0002-5776-2423","observed_orcids":["https://orcid.org/0000-0002-5776-2423"]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Ishii","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059888850","display_name":"Kazuhiro Kakizoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Kakizoe","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007676233","display_name":"Aya Taniguchi","orcid":"https://orcid.org/0000-0003-4925-3140","observed_orcids":["https://orcid.org/0000-0003-4925-3140"]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aya Taniguchi","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026418651","display_name":"Miki Tokuyasu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miki Tokuyasu","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021710290","display_name":"Taichi Himeno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taichi Himeno","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050493845","display_name":"Kazuhito Watanabe","orcid":"https://orcid.org/0000-0002-3778-182X","observed_orcids":["https://orcid.org/0000-0002-3778-182X"]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhito Watanabe","raw_affiliation_strings":["Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan","institution_ids":["https://openalex.org/I49155475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028135927","display_name":"Curtis J. Omiecinski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis J. Omiecinski","raw_affiliation_strings":["Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067248578","display_name":"Hironori Aramaki","orcid":"https://orcid.org/0000-0003-0499-0868","observed_orcids":["https://orcid.org/0000-0003-0499-0868"]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hironori Aramaki","raw_affiliation_strings":["Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan; Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan. Electronic address: haramaki@daiichi-cps.ac.jp","Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan; Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan. Electronic address: haramaki@daiichi-cps.ac.jp","institution_ids":["https://openalex.org/I2802008203"]},{"raw_affiliation_string":"Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067248578"],"corresponding_institution_ids":["https://openalex.org/I2802008203"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":2.3566,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.85217585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"326","issue":null,"first_page":"18","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.392300009727478,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta9-tetrahydrocannabinol","display_name":"delta-9-tetrahydrocannabinol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fatty-acid-2-hydroxylase","display_name":"FA2H","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6650000214576721},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cannabinoid-signaling","display_name":"cannabinoid signaling","score":0.6600000262260437},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.7156563401222229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5618581771850586},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.4868430495262146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4117637574672699},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3633929491043091},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3415125906467438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.275165855884552}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002722","descriptor_name":"Chlorobenzenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tox.2014.09.011","doi":"https://doi.org/10.1016/j.tox.2014.09.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2014.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:25291031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25291031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3227839","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/abstract/MED/25291031","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4258431","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4258431/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3227839","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/abstract/MED/25291031","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2333850438","display_name":"Targeting Dynamics of CAR and PXR in the Mouse and Human Genomes","funder_award_id":"R01GM066411","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5486451112","display_name":"Delta9-Tetrahydrocannabinol, a major component of marijuana, disrupts estrogen-signaling through estrogen receptor beta","funder_award_id":"25460182","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8824941148","display_name":"Interindividual Variability in Human Microsomal Epoxide Hydrolase","funder_award_id":"R01ES016358","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W114320787","https://openalex.org/W1967299835","https://openalex.org/W1967374891","https://openalex.org/W1969190280","https://openalex.org/W1976720772","https://openalex.org/W1981101682","https://openalex.org/W1984056625","https://openalex.org/W1988307205","https://openalex.org/W2006334693","https://openalex.org/W2010237936","https://openalex.org/W2011038073","https://openalex.org/W2013139454","https://openalex.org/W2018003279","https://openalex.org/W2019396114","https://openalex.org/W2020584025","https://openalex.org/W2034131665","https://openalex.org/W2037329582","https://openalex.org/W2045594266","https://openalex.org/W2059498883","https://openalex.org/W2062172999","https://openalex.org/W2078919991","https://openalex.org/W2089130879","https://openalex.org/W2094288583","https://openalex.org/W2094760916","https://openalex.org/W2096377599","https://openalex.org/W2097293959","https://openalex.org/W2111251212","https://openalex.org/W2112755850","https://openalex.org/W2113118782","https://openalex.org/W2124317382","https://openalex.org/W2134599380","https://openalex.org/W2136506025","https://openalex.org/W2136771849","https://openalex.org/W2139002144","https://openalex.org/W2145297882","https://openalex.org/W2145369111","https://openalex.org/W2148028702","https://openalex.org/W2151173006","https://openalex.org/W2216709092","https://openalex.org/W2313014814","https://openalex.org/W2334675414","https://openalex.org/W2334810900","https://openalex.org/W6647206636"],"related_works":["https://openalex.org/W2904914465","https://openalex.org/W7001154484","https://openalex.org/W2334675414","https://openalex.org/W1503846628","https://openalex.org/W2987270336","https://openalex.org/W4377020780","https://openalex.org/W4304123896","https://openalex.org/W4225819575","https://openalex.org/W1968630708","https://openalex.org/W7164632812"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
