{"id":"https://openalex.org/W2015264243","doi":"https://doi.org/10.1016/j.ejmech.2015.03.067","title":"Towards small molecule inhibitors of mono-ADP-ribosyltransferases","display_name":"Towards small molecule inhibitors of mono-ADP-ribosyltransferases","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W2015264243","doi":"https://doi.org/10.1016/j.ejmech.2015.03.067","mag":"2015264243","pmid":"https://pubmed.ncbi.nlm.nih.gov/25847771"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2015.03.067","doi":"https://doi.org/10.1016/j.ejmech.2015.03.067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2015.03.067","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0223523415002421/pdf","source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0223523415002421/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036215286","display_name":"Torun Ekblad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Torun Ekblad","raw_affiliation_strings":["Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110214064","display_name":"Anders E. G. Lindgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders E.G. Lindgren","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","Department of Chemistry, Umea University, SE 90187 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Department of Chemistry, Umea University, SE 90187 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. David Andersson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"C. David Andersson","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","Department of Chemistry, Umea University, SE 90187 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Department of Chemistry, Umea University, SE 90187 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058182950","display_name":"R\u00e9mi Caraballo","orcid":"https://orcid.org/0000-0001-5912-8429","observed_orcids":["https://orcid.org/0000-0001-5912-8429"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"R\u00e9mi Caraballo","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","Department of Chemistry, Umea University, SE 90187 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Department of Chemistry, Umea University, SE 90187 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045560512","display_name":"A.G. Thorsell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ann-Gerd Thorsell","raw_affiliation_strings":["Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018683664","display_name":"T. Karlberg","orcid":"https://orcid.org/0000-0002-5275-9460","observed_orcids":["https://orcid.org/0000-0002-5275-9460"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tobias Karlberg","raw_affiliation_strings":["Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074720898","display_name":"Sara Spjut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sara Spjut","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","Department of Chemistry, Umea University, SE 90187 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Department of Chemistry, Umea University, SE 90187 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056397946","display_name":"Anna Linusson","orcid":"https://orcid.org/0000-0003-0063-8912","observed_orcids":["https://orcid.org/0000-0003-0063-8912"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Linusson","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","Department of Chemistry, Umea University, SE 90187 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Department of Chemistry, Umea University, SE 90187 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078517414","display_name":"Herwig Schuler","orcid":"https://orcid.org/0000-0003-4059-3501","observed_orcids":["https://orcid.org/0000-0003-4059-3501"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Herwig Sch\u00fcler","raw_affiliation_strings":["Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. Electronic address: herwig.schuler@ki.se","Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4059-3501","affiliations":[{"raw_affiliation_string":"Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. Electronic address: herwig.schuler@ki.se","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072343210","display_name":"Mikael Elofsson","orcid":"https://orcid.org/0000-0002-3219-4669","observed_orcids":["https://orcid.org/0000-0002-3219-4669"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Mikael Elofsson","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden. Electronic address: mikael.elofsson@chem.umu.se","Department of Chemistry, Umea University, SE 90187 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden. Electronic address: mikael.elofsson@chem.umu.se","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Department of Chemistry, Umea University, SE 90187 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072343210","https://openalex.org/A5078517414"],"corresponding_institution_ids":["https://openalex.org/I28166907","https://openalex.org/I90267481"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":{"value":4650,"currency":"USD","value_usd":4650},"fwci":4.1787,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.96076689,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"95","issue":null,"first_page":"546","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mono-adp-ribosyltransferase","display_name":"mono-ADP-ribosyltransferase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.7089999914169312},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.5440000295639038},{"id":"https://openalex.org/keywords/inhibitor-synthesis","display_name":"inhibitor synthesis","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C45510557","wikidata":"https://www.wikidata.org/wiki/Q61420","display_name":"ADP-ribosylation","level":4,"score":0.7236791849136353},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.7133327722549438},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6780468225479126},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.595094621181488},{"id":"https://openalex.org/C33057221","wikidata":"https://www.wikidata.org/wiki/Q421580","display_name":"Diphtheria toxin","level":3,"score":0.4893586039543152},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.48813924193382263},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.47245481610298157},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.46902480721473694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.449482798576355},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.43366923928260803},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.433284193277359},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.34734901785850525},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33017778396606445},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.30277127027511597},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.25813835859298706}],"mesh":[{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ejmech.2015.03.067","doi":"https://doi.org/10.1016/j.ejmech.2015.03.067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2015.03.067","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0223523415002421/pdf","source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:25847771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25847771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:umu-106136","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ejmech.2015.03.067","doi":"https://doi.org/10.1016/j.ejmech.2015.03.067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2015.03.067","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0223523415002421/pdf","source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1328497706","display_name":null,"funder_award_id":"2012-5247","funder_id":"https://openalex.org/F4320321033","funder_display_name":"Svenska Forskningsr\u00e5det Formas"},{"id":"https://openalex.org/G2872782692","display_name":"Kemiska verktyg f\u00f6r att studera epigenetisk signalering","funder_award_id":"RBc08-0014","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G8236807698","display_name":"Structure-function analysis of PARP-family ADP-ribose transferases","funder_award_id":"2012-05247","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320321033","display_name":"Svenska Forskningsr\u00e5det Formas","ror":"https://ror.org/03pjs1y45"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F5043892423","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015264243.pdf","grobid_xml":"https://content.openalex.org/works/W2015264243.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W200431164","https://openalex.org/W1575178924","https://openalex.org/W1965006127","https://openalex.org/W1975272351","https://openalex.org/W1993582972","https://openalex.org/W1996995837","https://openalex.org/W1999460643","https://openalex.org/W2014875983","https://openalex.org/W2017171454","https://openalex.org/W2017387563","https://openalex.org/W2022350916","https://openalex.org/W2035098081","https://openalex.org/W2057023085","https://openalex.org/W2058058143","https://openalex.org/W2072493619","https://openalex.org/W2076592490","https://openalex.org/W2080422741","https://openalex.org/W2081630196","https://openalex.org/W2083059154","https://openalex.org/W2085215116","https://openalex.org/W2085789404","https://openalex.org/W2096529411","https://openalex.org/W2106714479","https://openalex.org/W2166571825","https://openalex.org/W2166594615","https://openalex.org/W2415998998","https://openalex.org/W4241294072","https://openalex.org/W6608244327"],"related_works":["https://openalex.org/W2072493619","https://openalex.org/W2887989764","https://openalex.org/W4224271887","https://openalex.org/W1992110781","https://openalex.org/W4385544179","https://openalex.org/W3171129155","https://openalex.org/W2809572644","https://openalex.org/W2609026834","https://openalex.org/W6911066110","https://openalex.org/W6964688311"],"abstract_inverted_index":{"Protein":[0],"ADP-ribosylation":[1,18],"is":[2,19],"a":[3,42],"post-translational":[4],"modification":[5],"involved":[6],"in":[7],"DNA":[8],"repair,":[9],"protein":[10],"degradation,":[11],"transcription":[12],"regulation,":[13],"and":[14,56,72,80],"epigenetic":[15],"events.":[16],"Intracellular":[17],"catalyzed":[20],"predominantly":[21],"by":[22],"ADP-ribosyltransferases":[23],"with":[24,60,90],"diphtheria":[25],"toxin":[26],"homology":[27],"(ARTDs).":[28],"The":[29,84],"most":[30,85],"prominent":[31],"member":[32],"of":[33,68],"the":[34,58,66,75,81],"ARTD":[35],"family,":[36],"poly(ADP-ribose)":[37],"polymerase-1":[38],"(ARTD1/PARP1)":[39],"has":[40],"been":[41],"target":[43],"for":[44,48],"cancer":[45],"drug":[46],"development":[47],"decades.":[49],"Current":[50],"PARP":[51],"inhibitors":[52],"are":[53],"generally":[54],"non-selective,":[55],"inhibit":[57],"mono-ADP-ribosyltransferases":[59,76],"low":[61],"potency.":[62],"Here":[63],"we":[64],"describe":[65],"synthesis":[67],"acylated":[69],"amino":[70],"benzamides":[71],"screening":[73],"against":[74],"ARTD7/PARP15,":[77],"ARTD8/PARP14,":[78],"ARTD10/PARP10,":[79],"poly-ADP-ribosyltransferase":[82],"ARTD1/PARP1.":[83],"potent":[86],"compound":[87],"inhibits":[88],"ARTD10":[89],"sub-micromolar":[91],"IC50.":[92]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
