{"id":"https://openalex.org/W2015230620","doi":"https://doi.org/10.1002/acr.20440","title":"Effects of rosuvastatin on vascular biomarkers and carotid atherosclerosis in lupus: A randomized, double\u2010blind, placebo\u2010controlled trial","display_name":"Effects of rosuvastatin on vascular biomarkers and carotid atherosclerosis in lupus: A randomized, double\u2010blind, placebo\u2010controlled trial","publication_year":2011,"publication_date":"2011-01-26","ids":{"openalex":"https://openalex.org/W2015230620","doi":"https://doi.org/10.1002/acr.20440","mag":"2015230620","pmid":"https://pubmed.ncbi.nlm.nih.gov/21309005"},"language":"en","primary_location":{"id":"doi:10.1002/acr.20440","doi":"https://doi.org/10.1002/acr.20440","is_oa":false,"landing_page_url":"https://doi.org/10.1002/acr.20440","pdf_url":null,"source":{"id":"https://openalex.org/S13698240","display_name":"Arthritis Care & Research","issn_l":"0893-7524","issn":["0893-7524","1529-0123","2151-464X","2151-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Care &amp; Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033947419","display_name":"Chi Chiu Mok","orcid":"https://orcid.org/0000-0003-3696-1228","observed_orcids":["https://orcid.org/0000-0003-3696-1228"]},"institutions":[{"id":"https://openalex.org/I2800783597","display_name":"Tuen Mun Hospital","ror":"https://ror.org/018nkky79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800783597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chi Chiu Mok","raw_affiliation_strings":["Tuen Mun Hospital, Hong Kong, China. ccmok2005@yahoo.com","Tuen Mun Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuen Mun Hospital, Hong Kong, China. ccmok2005@yahoo.com","institution_ids":["https://openalex.org/I2800783597"]},{"raw_affiliation_string":"Tuen Mun Hospital Hong Kong, China","institution_ids":["https://openalex.org/I2800783597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075382903","display_name":"Chun Kwok Wong","orcid":"https://orcid.org/0000-0002-5637-8331","observed_orcids":["https://orcid.org/0000-0002-5637-8331"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Chun Kwok Wong","raw_affiliation_strings":["Chinese University of Hong Kong, , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese University of Hong Kong, , China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101439084","display_name":"Chi Hung To","orcid":"https://orcid.org/0000-0002-5219-4332","observed_orcids":["https://orcid.org/0000-0002-5219-4332"]},"institutions":[{"id":"https://openalex.org/I2800783597","display_name":"Tuen Mun Hospital","ror":"https://ror.org/018nkky79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800783597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chi Hung To","raw_affiliation_strings":["Tuen Mun Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuen Mun Hospital Hong Kong, China","institution_ids":["https://openalex.org/I2800783597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110177905","display_name":"Judy Po Shan Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800783597","display_name":"Tuen Mun Hospital","ror":"https://ror.org/018nkky79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800783597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Judy Po Shan Lai","raw_affiliation_strings":["Tuen Mun Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuen Mun Hospital Hong Kong, China","institution_ids":["https://openalex.org/I2800783597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102390788","display_name":"Cheuk Sum Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800783597","display_name":"Tuen Mun Hospital","ror":"https://ror.org/018nkky79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800783597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheuk Sum Lam","raw_affiliation_strings":["Tuen Mun Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuen Mun Hospital Hong Kong, China","institution_ids":["https://openalex.org/I2800783597"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":5.1524,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.96015206,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"63","issue":"6","first_page":"875","last_page":"883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.2754000127315521,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rosuvastatin","display_name":"rosuvastatin","score":1.0},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9240000247955322},{"id":"https://openalex.org/keywords/subclinical-atherosclerosis","display_name":"subclinical atherosclerosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/vascular-markers","display_name":"vascular biomarkers","score":0.9160000085830688},{"id":"https://openalex.org/keywords/low-dose-aspirin","display_name":"low-dose aspirin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9330000281333923},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/soluble-vascular-cell-adhesion-molecule-1","display_name":"soluble vascular cell adhesion molecule-1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8539999723434448},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.861958384513855},{"id":"https://openalex.org/C2780499067","wikidata":"https://www.wikidata.org/wiki/Q415159","display_name":"Rosuvastatin","level":2,"score":0.8325257897377014},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6747699975967407},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.6651914119720459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.648603081703186},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6217375993728638},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5914716124534607},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.4927683174610138},{"id":"https://openalex.org/C2908737378","wikidata":"https://www.wikidata.org/wiki/Q415159","display_name":"Rosuvastatin Calcium","level":3,"score":0.4837755858898163},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.44301509857177734},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10142907500267029},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068718","descriptor_name":"Rosuvastatin Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005464","descriptor_name":"Fluorobenzenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018180","descriptor_name":"Thrombomodulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/acr.20440","doi":"https://doi.org/10.1002/acr.20440","is_oa":false,"landing_page_url":"https://doi.org/10.1002/acr.20440","pdf_url":null,"source":{"id":"https://openalex.org/S13698240","display_name":"Arthritis Care & Research","issn_l":"0893-7524","issn":["0893-7524","1529-0123","2151-464X","2151-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Care &amp; Research","raw_type":"journal-article"},{"id":"pmid:21309005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21309005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis care & research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1546258268","https://openalex.org/W1968240228","https://openalex.org/W1972751508","https://openalex.org/W1975307585","https://openalex.org/W2014530534","https://openalex.org/W2015878901","https://openalex.org/W2018379041","https://openalex.org/W2026129223","https://openalex.org/W2033357663","https://openalex.org/W2058242677","https://openalex.org/W2063414048","https://openalex.org/W2065538858","https://openalex.org/W2070671835","https://openalex.org/W2099717407","https://openalex.org/W2118154631","https://openalex.org/W2119475547","https://openalex.org/W2137983259","https://openalex.org/W2139168645","https://openalex.org/W2142043065","https://openalex.org/W2146203649","https://openalex.org/W2146872006","https://openalex.org/W2152130764","https://openalex.org/W2169503288","https://openalex.org/W2171971495"],"related_works":["https://openalex.org/W7096836844","https://openalex.org/W2116079924","https://openalex.org/W2418558163","https://openalex.org/W2102364720","https://openalex.org/W7128036273","https://openalex.org/W2378659532","https://openalex.org/W7171668841","https://openalex.org/W811660035","https://openalex.org/W1999140731","https://openalex.org/W2365260893"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2,135],"the":[3,69,134,153,159,200,216,219,276,279],"effect":[4],"of":[5,78,103,133,218,225,278],"rosuvastatin":[6,38,63,201,271,302],"on":[7,68],"vascular":[8,85],"biomarkers":[9,220],"and":[10,26,64,91,99,148,179,210,255,310],"carotid":[11,104,281],"intima-media":[12],"thickness":[13],"(IMT)":[14],"in":[15,31,45,139,199,208,241,287,308],"systemic":[16],"lupus":[17],"erythematosus":[18],"(SLE).":[19],"METHODS:":[20],"SLE":[21,299],"patients":[22,113,127,138,226,288],"with":[23,62,227,270,290],"inactive":[24],"disease":[25],"subclinical":[27],"atherosclerosis":[28],"were":[29,48,66,93,114,128,150],"randomized":[30],"a":[32,228,238,305],"double-blinded":[33],"manner":[34],"to":[35,131,171,189,247,262,284,304,317],"receive":[36],"either":[37],"(10":[39],"mg/day)":[40],"or":[41],"matching":[42],"placebo":[43],"(half":[44],"each":[46,132,140],"group":[47],"also":[49,142],"randomly":[50,129],"allocated":[51],"low-dose":[52,301],"aspirin).":[53,144],"After":[54],"12":[55,74,100,157],"months,":[56,98,158,275],"treatment":[57],"was":[58,106,204,293],"unblinded.":[59],"Patients":[60],"treated":[61,289],"aspirin":[65,211],"continued":[67],"same":[70],"medications":[71,149],"for":[72],"another":[73],"months.":[75,101,110],"Plasma":[76],"levels":[77,182,217,257],"homocysteine,":[79,209],"high-sensitivity":[80],"C-reactive":[81],"protein":[82],"(hsCRP),":[83],"soluble":[84],"cell":[86],"adhesion":[87],"molecule":[88],"1,":[89],"P-selectin,":[90],"thrombomodulin":[92,256,311],"measured":[94],"at":[95,108],"baseline,":[96],"6":[97],"Measurement":[102],"IMT":[105,277],"repeated":[107],"24":[109,274],"RESULTS:":[111],"Seventy-two":[112],"studied":[115],"(97%":[116],"women,":[117],"mean":[118,160],"\u00b1":[119,123,165,168,173],"SD":[120,166],"age":[121],"50.8":[122],"9.7":[124],"years).":[125],"Thirty-six":[126],"assigned":[130],"arms":[136],"(18":[137],"arm":[141],"received":[143],"Baseline":[145],"clinical":[146],"characteristics":[147],"similar":[151],"between":[152],"two":[154],"groups.":[155],"At":[156,273],"low-density":[161],"lipoprotein":[162],"cholesterol":[163],"(mean":[164],"2.62":[167],"1.04":[169],"mmoles/liter":[170],"1.69":[172],"0.72":[174],"mmoles/liter;":[175],"P":[176,194,252,267],"<":[177],"0.001)":[178,269],"median":[180],"hsCRP":[181,242,309],"(1.26":[183],"mg/liter,":[184,191,244,249],"interquartile":[185],"range":[186],"[IQR]":[187],"2.3":[188,246],"0.88":[190],"IQR":[192,245,250,260,265],"1.1;":[193,251],"=":[195,253,268],"0.02)":[196],"decreased":[197,286],"significantly":[198],"group.":[202],"There":[203],"no":[205],"significant":[206,239,306],"change":[207],"use":[212],"did":[213],"not":[214],"influence":[215],"studied.":[221],"A":[222],"subgroup":[223],"analysis":[224],"Systemic":[229],"Lupus":[230],"Erythematosus":[231],"Disease":[232],"Activity":[233],"Index":[234],"score":[235],"\u22642":[236],"revealed":[237],"decrease":[240],"(1.20":[243],"0.92":[248],"0.04)":[254],"(0.76":[258],"ng/ml,":[259,264],"1.2":[261],"0.67":[263],"1.0;":[266],"treatment.":[272],"internal":[280],"arteries":[282],"appeared":[283],"be":[285],"rosuvastatin,":[291],"which":[292,313],"well":[294],"tolerated.":[295],"CONCLUSION:":[296],"In":[297],"stable":[298],"patients,":[300],"leads":[303],"reduction":[307],"levels,":[312],"may":[314],"possibly":[315],"help":[316],"reduce":[318],"cardiovascular":[319],"risk.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
