{"id":"https://openalex.org/W2015223945","doi":"https://doi.org/10.1006/cyto.2002.2011","title":"CONTRIBUTION OF CIRCULATING LEUKOCYTES TO CYTOKINE PRODUCTION IN PANCREATIC DUCT OBSTRUCTION-INDUCED ACUTE PANCREATITIS IN RATS","display_name":"CONTRIBUTION OF CIRCULATING LEUKOCYTES TO CYTOKINE PRODUCTION IN PANCREATIC DUCT OBSTRUCTION-INDUCED ACUTE PANCREATITIS IN RATS","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2015223945","doi":"https://doi.org/10.1006/cyto.2002.2011","mag":"2015223945","pmid":"https://pubmed.ncbi.nlm.nih.gov/12633572"},"language":"en","primary_location":{"id":"doi:10.1006/cyto.2002.2011","doi":"https://doi.org/10.1006/cyto.2002.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cyto.2002.2011","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000824900","display_name":"Isabel DE DIOS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel de Dios","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain. bel@gugu.usal.es","Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain. bel@gugu.usal.es","institution_ids":["https://openalex.org/I184999862"]},{"raw_affiliation_string":"Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030925049","display_name":"Mart\u00edn P\u00e9rez\u2010Andr\u00e9s","orcid":"https://orcid.org/0000-0003-4599-0776","observed_orcids":["https://orcid.org/0000-0003-4599-0776"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Martin Perez","raw_affiliation_strings":["Flow Cytometry Service, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Service, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035835338","display_name":"A.M de la Mano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana de La Mano","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]},{"raw_affiliation_string":"Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023810607","display_name":"Sara Sevillano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sara Sevillano","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]},{"raw_affiliation_string":"Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088409474","display_name":"Alberto \u00d3rf\u00e3o","orcid":"https://orcid.org/0000-0002-0007-7230","observed_orcids":["https://orcid.org/0000-0002-0007-7230"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Orfao","raw_affiliation_strings":["Flow Cytometry Service, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Service, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035822761","display_name":"Laura Ramudo","orcid":"https://orcid.org/0000-0002-3451-9244","observed_orcids":["https://orcid.org/0000-0002-3451-9244"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Ramudo","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]},{"raw_affiliation_string":"Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113556488","display_name":"Manuel Antonio Manso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Antonio Manso","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]},{"raw_affiliation_string":"Department of Physiology & Pharmacology, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184999862"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":3.6773,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.92131044,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"6","first_page":"295","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pancreatic-duct-obstruction","display_name":"pancreatic duct obstruction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/circulating-leukocytes","display_name":"circulating leukocytes","score":0.953000009059906},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9919999837875366},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7229999899864197},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.968999981880188},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7689999938011169},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pma-ionomycin-stimulation","display_name":"PMA/ionomycin stimulation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cd11b","display_name":"CD11b","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.8012323379516602},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.7410577535629272},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5605536103248596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5544007420539856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5466743111610413},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.48633891344070435},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.4825667440891266},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.44592276215553284},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4392060935497284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40353015065193176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3859327435493469},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36974036693573}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/cyto.2002.2011","doi":"https://doi.org/10.1006/cyto.2002.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cyto.2002.2011","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},{"id":"pmid:12633572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12633572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W57967720","https://openalex.org/W117432842","https://openalex.org/W180338758","https://openalex.org/W637769748","https://openalex.org/W1569113772","https://openalex.org/W1603492810","https://openalex.org/W1819705760","https://openalex.org/W1886020135","https://openalex.org/W1967002916","https://openalex.org/W1967329990","https://openalex.org/W1987642364","https://openalex.org/W1997632362","https://openalex.org/W2007433998","https://openalex.org/W2017116431","https://openalex.org/W2022580158","https://openalex.org/W2025986194","https://openalex.org/W2034338667","https://openalex.org/W2037909767","https://openalex.org/W2043168251","https://openalex.org/W2046478175","https://openalex.org/W2046979440","https://openalex.org/W2049868653","https://openalex.org/W2052005512","https://openalex.org/W2057807822","https://openalex.org/W2066254024","https://openalex.org/W2066277926","https://openalex.org/W2076278533","https://openalex.org/W2081935849","https://openalex.org/W2085323817","https://openalex.org/W2088406252","https://openalex.org/W2092228454","https://openalex.org/W2093943951","https://openalex.org/W2099814989","https://openalex.org/W2113039096","https://openalex.org/W2113810300","https://openalex.org/W2119160047","https://openalex.org/W2125796919","https://openalex.org/W2127877851","https://openalex.org/W2158956822","https://openalex.org/W2171290005","https://openalex.org/W2176899369","https://openalex.org/W2177675467","https://openalex.org/W4231581694"],"related_works":["https://openalex.org/W2002719282","https://openalex.org/W2047320981","https://openalex.org/W2030179158","https://openalex.org/W2026531996","https://openalex.org/W1563828805","https://openalex.org/W2057599182","https://openalex.org/W2083589550","https://openalex.org/W2158990429","https://openalex.org/W1569667056","https://openalex.org/W2402131614"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}