{"id":"https://openalex.org/W2015216655","doi":"https://doi.org/10.1210/endo-90-4-992","title":"An Intercellular Response to Estrogen by Granulosa Cells in the Rat Ovary; An Electron Microscope Study*","display_name":"An Intercellular Response to Estrogen by Granulosa Cells in the Rat Ovary; An Electron Microscope Study*","publication_year":1972,"publication_date":"1972-04-01","ids":{"openalex":"https://openalex.org/W2015216655","doi":"https://doi.org/10.1210/endo-90-4-992","mag":"2015216655","pmid":"https://pubmed.ncbi.nlm.nih.gov/5011067"},"language":"en","primary_location":{"id":"doi:10.1210/endo-90-4-992","doi":"https://doi.org/10.1210/endo-90-4-992","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-90-4-992","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108202154","display_name":"Frederick B. Merk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FREDERICK B. MERK","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts, 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts, 02215","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016290298","display_name":"Charles R. Botticelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHARLES R. BOTTICELLI","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts, 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts, 02215","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111586785","display_name":"John T. Albright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN T. ALBRIGHT","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts, 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts, 02215","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":14.8294,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.98916835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"90","issue":"4","first_page":"992","last_page":"1007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.13619999587535858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.5139999985694885},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ovarian-follicles","display_name":"ovarian follicles","score":0.7229999899864197},{"id":"https://openalex.org/keywords/diethylstilbestrol","display_name":"diethylstilbestrol","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.843999981880188},{"id":"https://openalex.org/keywords/intercellular-junctions","display_name":"intercellular junctions","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nexus","display_name":"NEXUS","score":0.8190000057220459},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.7350000143051147},{"id":"https://openalex.org/keywords/immature-rats","display_name":"immature rats","score":0.6039999723434448},{"id":"https://openalex.org/keywords/preovulatory-follicles","display_name":"preovulatory follicles","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.7651355266571045},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6624651551246643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6564744114875793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6448373198509216},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.6125280857086182},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5060688853263855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42296916246414185},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3755013644695282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21040421724319458},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20588263869285583},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06444445252418518},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004054","descriptor_name":"Diethylstilbestrol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-90-4-992","doi":"https://doi.org/10.1210/endo-90-4-992","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-90-4-992","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:5011067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5011067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149573140","https://openalex.org/W2004987983","https://openalex.org/W2021445249","https://openalex.org/W2044746275","https://openalex.org/W2077018960","https://openalex.org/W2039980719","https://openalex.org/W2098332112","https://openalex.org/W2065914273","https://openalex.org/W2130474704","https://openalex.org/W2033366577"],"abstract_inverted_index":{"ABSTRACT.":[0],"Ultrastructural":[1],"responses":[2],"of":[3,23,45,80,88,130,136,142],"ovarian":[4,75],"granulosa":[5,137],"cells":[6,87],"to":[7,73,116],"exogenous":[8],"estrogen":[9],"have":[10],"been":[11],"investigated":[12],"in":[13,86,100,121,140],"immature":[14],"rats.":[15,148],"Animals,":[16],"21-daysold,":[17],"were":[18,42,54,68],"hypophysectomized":[19,147],"and":[20,40,133],"a":[21,94],"regimen":[22],"6":[24,48],"daily":[25],"injections":[26],"was":[27],"initiated":[28],"30":[29],"hr":[30,59],"after":[31,60],"the":[32,61,78,89,101,128,134,150],"operation.":[33],"Some":[34],"rats":[35,67],"received":[36],"sesame":[37],"oil":[38],"only":[39],"others":[41],"given":[43],"totals":[44],"3":[46],"or":[47],"mg":[49],"diethylstilbestrol":[50],"(DES).":[51],"Ovarian":[52],"tissues":[53],"prepared":[55],"for":[56,96],"microscopy":[57],"24":[58],"last":[62],"injection.":[63],"In":[64],"addition,":[65],"normal":[66,143],"sacrificed":[69],"at":[70,77],"21":[71],"days":[72],"monitor":[74],"morphology":[76],"time":[79],"hypophysectomy.":[81],"Rapid":[82],"simultaneous":[83],"changes,":[84],"occurring":[85],"pre-ovulatory":[90],"rat":[91],"follicle,":[92],"suggest":[93],"necessity":[95],"cell":[97,138],"communication,":[98],"particularly":[99],"multilayered":[102],"avascular":[103],"granulosa.":[104],"Therefore,":[105],"emphasis":[106],"is":[107,125],"placed":[108],"on":[109],"an":[110,118],"intercellular":[111],"junction":[112],"(the":[113],"nexus)":[114],"thought":[115],"play":[117],"important":[119],"role":[120],"communication.":[122],"A":[123],"correlation":[124],"made":[126],"between":[127],"extent":[129],"thecal":[131],"development":[132],"incidence":[135],"nexuses":[139],"follicles":[141],"as":[144,146],"well":[145],"If":[149],"\u201cthec...":[151]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}