{"id":"https://openalex.org/W2015202978","doi":"https://doi.org/10.1074/jbc.274.29.20281","title":"Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1","display_name":"Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2015202978","doi":"https://doi.org/10.1074/jbc.274.29.20281","mag":"2015202978","pmid":"https://pubmed.ncbi.nlm.nih.gov/10400647"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.29.20281","doi":"https://doi.org/10.1074/jbc.274.29.20281","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.29.20281","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.274.29.20281","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109574864","display_name":"Andreas Barthel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas Barthel","raw_affiliation_strings":["Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027705783","display_name":"Steven T. Okino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven T. Okino","raw_affiliation_strings":["From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057976112","display_name":"Jinfang Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinfang Liao","raw_affiliation_strings":["From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027464317","display_name":"Kaname Nakatani","orcid":"https://orcid.org/0000-0001-6709-541X","observed_orcids":["https://orcid.org/0000-0001-6709-541X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaname Nakatani","raw_affiliation_strings":["From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100603461","display_name":"Jin\u2010Ping Li","orcid":"https://orcid.org/0000-0002-4255-3581","observed_orcids":["https://orcid.org/0000-0002-4255-3581","https://orcid.org/0009-0005-1990-299X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinping Li","raw_affiliation_strings":["From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112727836","display_name":"James P. Whitlock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Whitlock","raw_affiliation_strings":["From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103438325","display_name":"Richard A. Roth","orcid":"https://orcid.org/0000-0001-9714-4745","observed_orcids":["https://orcid.org/0000-0001-9714-4745"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard A. Roth","raw_affiliation_strings":["From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103438325"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.6913,"has_fulltext":false,"cited_by_count":328,"citation_normalized_percentile":{"value":0.9397905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"274","issue":"29","first_page":"20281","last_page":"20286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.75},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.5180000066757202},{"id":"https://openalex.org/keywords/hepatoma-cells","display_name":"hepatoma cells","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mrna-synthesis","display_name":"mRNA synthesis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.6050000190734863},{"id":"https://openalex.org/keywords/kinase-activity","display_name":"kinase activity","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.931019127368927},{"id":"https://openalex.org/C88216763","wikidata":"https://www.wikidata.org/wiki/Q4652205","display_name":"AKT2","level":5,"score":0.8867290019989014},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.874821662902832},{"id":"https://openalex.org/C154779307","wikidata":"https://www.wikidata.org/wiki/Q18034943","display_name":"AKT3","level":5,"score":0.6735782027244568},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.49595603346824646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46340322494506836},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41378918290138245},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37556490302085876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3309888243675232}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.29.20281","doi":"https://doi.org/10.1074/jbc.274.29.20281","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.29.20281","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10400647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10400647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.29.20281","doi":"https://doi.org/10.1074/jbc.274.29.20281","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.29.20281","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4245170535","display_name":null,"funder_award_id":"DK34926","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6216579798","display_name":null,"funder_award_id":"ES 08655","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6362790579","display_name":"ADAPTATION TO ENVIRONMENTAL STRESS--MECHANISTIC ANALYSES","funder_award_id":"R01ES008655","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W34285493","https://openalex.org/W177380973","https://openalex.org/W1529396499","https://openalex.org/W1543750783","https://openalex.org/W1568605582","https://openalex.org/W1593855912","https://openalex.org/W1599478288","https://openalex.org/W1602403912","https://openalex.org/W1606639029","https://openalex.org/W1791888878","https://openalex.org/W1841050729","https://openalex.org/W1876033686","https://openalex.org/W1944789111","https://openalex.org/W1966099909","https://openalex.org/W1972307668","https://openalex.org/W1975313140","https://openalex.org/W1976288322","https://openalex.org/W1983566655","https://openalex.org/W1989294105","https://openalex.org/W1993836723","https://openalex.org/W1997054933","https://openalex.org/W2001001554","https://openalex.org/W2015437728","https://openalex.org/W2019759067","https://openalex.org/W2020790836","https://openalex.org/W2026802896","https://openalex.org/W2034777081","https://openalex.org/W2059424055","https://openalex.org/W2067677059","https://openalex.org/W2071686558","https://openalex.org/W2074854450","https://openalex.org/W2075104267","https://openalex.org/W2085814948","https://openalex.org/W2085837280","https://openalex.org/W2087085892","https://openalex.org/W2119744230","https://openalex.org/W2124432707","https://openalex.org/W2152127342","https://openalex.org/W2380936111"],"related_works":["https://openalex.org/W1975313140","https://openalex.org/W2028043988","https://openalex.org/W2124880593","https://openalex.org/W1598767975","https://openalex.org/W2024524127","https://openalex.org/W588506659","https://openalex.org/W2037308821","https://openalex.org/W2171404549","https://openalex.org/W1602403912","https://openalex.org/W1989294105"],"abstract_inverted_index":{"We":[0],"used":[1],"mouse":[2],"hepatoma":[3],"(Hepa1c1c7)":[4],"cells":[5],"to":[6,24,56,83,86,98,122,155],"study":[7],"the":[8,11,16,28,46,61,94,116,119,128,151,158,168],"role":[9],"of":[10,18,37,63,73,93,109,118,130,170],"serine/threonine":[12],"kinase":[13,30],"Akt":[14,29,38,65,95,112,134,163],"in":[15,45,103,167,174],"induction":[17,129],"GLUT1":[19,78,100,120,131,152,171],"gene":[20,101,121,153,172],"expression.":[21],"In":[22],"order":[23],"selectively":[25],"turn":[26],"on":[27],"cascade,":[31],"we":[32,49],"expressed":[33],"a":[34,57,110,165],"hydroxytamoxifen-regulatable":[35],"form":[36],"(myristoylated":[39],"Akt1":[40],"estrogen":[41],"receptor":[42],"chimera":[43],"(MER-Akt1))":[44],"Hepa1c1c7":[47],"cells;":[48],"verified":[50],"that":[51,71,87,127,150,162],"hydroxytamoxifen":[52,76],"stimulates":[53],"MER-Akt1":[54,74],"activity":[55],"similar":[58],"extent":[59],"as":[60],"activation":[62,92,169],"endogenous":[64],"by":[66,75,89,133,136],"insulin.":[67,123],"Our":[68,147],"studies":[69,125],"reveal":[70,126],"stimulation":[72],"induces":[77],"mRNA":[79,132,140,145],"and":[80,135,142,161],"protein":[81],"accumulation":[82],"levels":[84],"comparable":[85],"induced":[88],"insulin;":[90],"therefore,":[91],"cascade":[96],"suffices":[97],"induce":[99],"expression":[102,108,173],"this":[104,175],"cell":[105],"system.":[106,176],"Furthermore,":[107],"kinase-inactive":[111],"mutant":[113],"partially":[114],"inhibits":[115],"response":[117],"Additional":[124],"insulin":[137,156],"reflects":[138],"increased":[139],"synthesis":[141],"not":[143],"decreased":[144],"degradation.":[146],"findings":[148],"imply":[149],"responds":[154],"at":[157],"transcriptional":[159],"level":[160],"mediates":[164],"step":[166]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}