{"id":"https://openalex.org/W2015199000","doi":"https://doi.org/10.1089/107999099313640","title":"Antioxidants Attenuate Acute Toxicity of Tumor Necrosis Factor-alpha Induced by Brain Injury in Rat","display_name":"Antioxidants Attenuate Acute Toxicity of Tumor Necrosis Factor-alpha Induced by Brain Injury in Rat","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2015199000","doi":"https://doi.org/10.1089/107999099313640","mag":"2015199000","pmid":"https://pubmed.ncbi.nlm.nih.gov/10454350"},"language":"en","primary_location":{"id":"doi:10.1089/107999099313640","doi":"https://doi.org/10.1089/107999099313640","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999099313640","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111675981","display_name":"Victoria Trembovler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Victoria Trembovler","raw_affiliation_strings":["Department of Pharmacology, The Hebrew University, School of Pharmacy and Medicine, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Hebrew University, School of Pharmacy and Medicine, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021829215","display_name":"Elie Beit\u2010Yannai","orcid":"https://orcid.org/0000-0001-9347-822X","observed_orcids":["https://orcid.org/0000-0001-9347-822X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elie Beit-Yannai","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011083210","display_name":"Firas M. Younis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Firas Younis","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086332980","display_name":"Ruth Gallily","orcid":"https://orcid.org/0000-0002-2106-3460","observed_orcids":["https://orcid.org/0000-0002-2106-3460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth Gallily","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035023438","display_name":"Michal Horowitz","orcid":"https://orcid.org/0000-0003-0516-5851","observed_orcids":["https://orcid.org/0000-0003-0516-5851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Horowitz","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016644943","display_name":"Esther Shohami","orcid":"https://orcid.org/0000-0001-7651-5228","observed_orcids":["https://orcid.org/0000-0001-7651-5228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther Shohami","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8596,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.89646652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"19","issue":"7","first_page":"791","last_page":"795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.996999979019165},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tempol","display_name":"tempol","score":0.8740000128746033},{"id":"https://openalex.org/keywords/nitroxide-radicals","display_name":"nitroxide radicals","score":0.7620000243186951},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8050000071525574},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8799999952316284},{"id":"https://openalex.org/keywords/closed-head-injury","display_name":"closed head injury","score":0.9879999756813049},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8429999947547913},{"id":"https://openalex.org/keywords/heat-acclimation","display_name":"heat acclimation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7799999713897705},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7110000252723694},{"id":"https://openalex.org/keywords/endogenous-antioxidants","display_name":"endogenous antioxidants","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.778712272644043},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6573240756988525},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5674991607666016},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5655405521392822},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5446471571922302},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5274410843849182},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5220624804496765},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5215175747871399},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.4839956760406494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4745517671108246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4208364486694336},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4170486629009247},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.41494864225387573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31591713428497314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2739604413509369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2222585380077362},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17829740047454834},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17677077651023865},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08484712243080139},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003497","descriptor_name":"Cyclic N-Oxides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016489","descriptor_name":"Head Injuries, Closed","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016489","descriptor_name":"Head Injuries, Closed","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/107999099313640","doi":"https://doi.org/10.1089/107999099313640","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999099313640","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},{"id":"pmid:10454350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10454350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W104389636","https://openalex.org/W115895558","https://openalex.org/W282565772","https://openalex.org/W1496877897","https://openalex.org/W1568529372","https://openalex.org/W1887482671","https://openalex.org/W1967081185","https://openalex.org/W1971216963","https://openalex.org/W1973554117","https://openalex.org/W1976750335","https://openalex.org/W1982838274","https://openalex.org/W1987036493","https://openalex.org/W1994192842","https://openalex.org/W2020303700","https://openalex.org/W2024906564","https://openalex.org/W2029545663","https://openalex.org/W2030485098","https://openalex.org/W2033913986","https://openalex.org/W2055257936","https://openalex.org/W2055859653","https://openalex.org/W2063081233","https://openalex.org/W2069333165","https://openalex.org/W2076339827","https://openalex.org/W2084473246","https://openalex.org/W2091394421","https://openalex.org/W2096091602","https://openalex.org/W2122175586","https://openalex.org/W2132482183","https://openalex.org/W2149818957","https://openalex.org/W2417546929","https://openalex.org/W4300196626","https://openalex.org/W4313333645"],"related_works":["https://openalex.org/W2076339827","https://openalex.org/W2059407857","https://openalex.org/W1540863311","https://openalex.org/W2034540486","https://openalex.org/W1996160406","https://openalex.org/W1603434131","https://openalex.org/W2899784799","https://openalex.org/W2126749451","https://openalex.org/W2045210813","https://openalex.org/W2030485098"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor-alpha":[2],"alpha":[3],"(TNF-alpha)":[4],"and":[5,18,41,76,107,181],"reactive":[6],"oxygen":[7],"species":[8],"(ROS)":[9],"are":[10],"produced":[11],"in":[12,52,55,137,150,192],"the":[13,31,35,43,57,72,126,140,151,166,189,204],"brain":[14,90,162],"after":[15,50,66,78,82,118,182],"traumatic":[16],"injury":[17,29,119],"have":[19,60],"deleterious":[20],"effects.":[21],"In":[22],"a":[23],"rat":[24],"model":[25],"of":[26,92,96,124,128,139,158,165,203],"closed":[27],"head":[28],"(CHI),":[30],"synthetic":[32],"antioxidant":[33],"from":[34],"nitroxide":[36],"family,":[37],"Tempol,":[38],"improved":[39],"recovery":[40,134],"protected":[42],"blood-brain":[44,167],"barrier.":[45],"Similar":[46],"protection":[47],"was":[48,130,135,146,177],"found":[49],"CHI":[51],"heat-acclimated":[53,109],"rats,":[54],"which":[56],"endogenous":[58],"antioxidants":[59,84,194],"been":[61],"shown":[62],"to":[63,100],"be":[64],"elevated":[65],"CHI.":[67],"The":[68],"present":[69],"study":[70],"examined":[71],"relationship":[73],"between":[74],"TNF-alpha":[75,129,144,159,196],"ROS":[77],"CHI,":[79,83],"namely,":[80],"whether":[81],"that":[85,191],"afforded":[86],"cerebroprotection":[87],"also":[88],"attenuated":[89,178],"levels":[91],"TNF-alpha.":[93],"Three":[94],"groups":[95],"rats":[97,138],"were":[98],"subjected":[99],"CHI:":[101],"(1)":[102],"control,":[103],"nontreated,":[104],"(2)":[105],"Tempol-treated,":[106],"(3)":[108],"(30":[110],"days":[111],"at":[112],"34":[113],"degrees":[114],"C).":[115],"Four":[116],"hours":[117],"(time":[120],"for":[121],"peak":[122],"production":[123],"TNF-alpha),":[125],"activity":[127,145],"measured.":[131],"Although":[132],"clinical":[133],"facilitated":[136],"two":[141],"treated":[142],"groups,":[143],"as":[147,149],"high":[148],"traumatized,":[152],"untreated":[153],"rats.":[154],"Moreover,":[155],"direct":[156],"injection":[157],"into":[160],"mouse":[161],"induced":[163],"disruption":[164],"barrier,":[168],"indicating":[169],"its":[170],"acute":[171],"harmful":[172],"effect.":[173],"This":[174],"toxic":[175],"effect":[176],"by":[179,199],"before":[180],"treatment":[183],"with":[184,201],"Tempol.":[185],"Our":[186],"results":[187],"support":[188],"hypothesis":[190],"vivo":[193],"neutralize":[195],"toxicity,":[197],"probably":[198],"interfering":[200],"activation":[202],"transcription":[205],"factor":[206],"NF-kappa-B.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}