{"id":"https://openalex.org/W2015188671","doi":"https://doi.org/10.1097/00129334-200401000-00012","title":"Growth Factors and Chronic Wound Healing: Past, Present, and Future","display_name":"Growth Factors and Chronic Wound Healing: Past, Present, and Future","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2015188671","doi":"https://doi.org/10.1097/00129334-200401000-00012","mag":"2015188671","pmid":"https://pubmed.ncbi.nlm.nih.gov/14752324"},"language":"en","primary_location":{"id":"doi:10.1097/00129334-200401000-00012","doi":"https://doi.org/10.1097/00129334-200401000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00129334-200401000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S162191074","display_name":"Advances in Skin & Wound Care","issn_l":"1527-7941","issn":["1527-7941","1538-8654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Skin & Wound Care","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010793735","display_name":"Robert J. Goldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Goldman","raw_affiliation_strings":["Department of Rehabilitation Medicine, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010793735"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":3.3018,"has_fulltext":false,"cited_by_count":327,"citation_normalized_percentile":{"value":0.95767575,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"24","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.7429999709129333},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8040000200271606},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/keratinocyte-growth-factor","display_name":"keratinocyte growth factor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9890000224113464},{"id":"https://openalex.org/keywords/becaplermin","display_name":"becaplermin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7719491124153137},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.765844464302063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.717738687992096},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.7165148854255676},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.6632668972015381},{"id":"https://openalex.org/C2778615670","wikidata":"https://www.wikidata.org/wiki/Q3811988","display_name":"Keratinocyte growth factor","level":4,"score":0.5363584160804749},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5231375098228455},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.49555671215057373},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.46304112672805786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41976478695869446},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3973004221916199},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3415151834487915},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33034735918045044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29959142208099365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2219219207763672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19061189889907837},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13699615001678467}],"mesh":[{"descriptor_ui":"D000077214","descriptor_name":"Becaplermin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00129334-200401000-00012","doi":"https://doi.org/10.1097/00129334-200401000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00129334-200401000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S162191074","display_name":"Advances in Skin & Wound Care","issn_l":"1527-7941","issn":["1527-7941","1538-8654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Skin & Wound Care","raw_type":"journal-article"},{"id":"pmid:14752324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14752324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in skin & wound care","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W59778569","https://openalex.org/W107705299","https://openalex.org/W140241974","https://openalex.org/W141591003","https://openalex.org/W165446420","https://openalex.org/W181443925","https://openalex.org/W1277182343","https://openalex.org/W1503290529","https://openalex.org/W1508203333","https://openalex.org/W1527208138","https://openalex.org/W1547475680","https://openalex.org/W1934754959","https://openalex.org/W1965327586","https://openalex.org/W1971394402","https://openalex.org/W1974562534","https://openalex.org/W1976155616","https://openalex.org/W1979364075","https://openalex.org/W1980923037","https://openalex.org/W1983007964","https://openalex.org/W1983187343","https://openalex.org/W1986585534","https://openalex.org/W1992872297","https://openalex.org/W1993950854","https://openalex.org/W1995720047","https://openalex.org/W2002956742","https://openalex.org/W2006027198","https://openalex.org/W2007716988","https://openalex.org/W2013263828","https://openalex.org/W2015776844","https://openalex.org/W2021489532","https://openalex.org/W2022380979","https://openalex.org/W2027626402","https://openalex.org/W2035683007","https://openalex.org/W2036173323","https://openalex.org/W2036857231","https://openalex.org/W2041437171","https://openalex.org/W2044214845","https://openalex.org/W2047428308","https://openalex.org/W2056105632","https://openalex.org/W2058087004","https://openalex.org/W2058460635","https://openalex.org/W2060363425","https://openalex.org/W2062093468","https://openalex.org/W2068061989","https://openalex.org/W2069160715","https://openalex.org/W2071322590","https://openalex.org/W2071574094","https://openalex.org/W2072847918","https://openalex.org/W2077355093","https://openalex.org/W2084099797","https://openalex.org/W2084121599","https://openalex.org/W2095318593","https://openalex.org/W2101703166","https://openalex.org/W2105421453","https://openalex.org/W2106499996","https://openalex.org/W2108104357","https://openalex.org/W2110051960","https://openalex.org/W2115465396","https://openalex.org/W2116568004","https://openalex.org/W2119750705","https://openalex.org/W2120500721","https://openalex.org/W2123434168","https://openalex.org/W2124471328","https://openalex.org/W2128087994","https://openalex.org/W2134996775","https://openalex.org/W2137838799","https://openalex.org/W2140273413","https://openalex.org/W2144533837","https://openalex.org/W2159634847","https://openalex.org/W2167533411","https://openalex.org/W2168132872","https://openalex.org/W2265310757","https://openalex.org/W2395763616","https://openalex.org/W2428630324","https://openalex.org/W2603360489"],"related_works":["https://openalex.org/W1968528332","https://openalex.org/W2249069816","https://openalex.org/W2040108044","https://openalex.org/W1949832432","https://openalex.org/W2400597336","https://openalex.org/W46295608","https://openalex.org/W4390345103","https://openalex.org/W2414876288","https://openalex.org/W139988424","https://openalex.org/W2079023278"],"abstract_inverted_index":{"In":[0],"Brief":[1],"Growth":[2],"substances":[3],"(cytokines":[4],"and":[5,27,45,77,147,155],"growth":[6,36,39,43,47,51,71,95,104,132,153],"factors)":[7],"are":[8],"soluble":[9],"signaling":[10],"proteins":[11],"affecting":[12],"the":[13,21,55,69,75,158],"process":[14],"of":[15,64,150],"normal":[16],"wound":[17,65,85],"healing.":[18,66,86],"Cytokines":[19],"govern":[20],"inflammatory":[22],"phase":[23,116],"that":[24],"clears":[25],"cellular":[26],"extracellular":[28],"matrix":[29],"debris.":[30],"Wound":[31],"repair":[32],"is":[33,59,89],"controlled":[34],"by":[35,74],"factors":[37,52,133,154],"(platelet-derived":[38],"factor":[40,48,72,96,105],"[PDGF],":[41],"keratinocyte":[42],"factor,":[44],"transforming":[46],"\u03b2).":[49],"Endogenous":[50],"communicate":[53],"across":[54],"dermal-epidermal":[56],"interface.":[57],"PDGF":[58,123],"important":[60],"for":[61,83,92,107,138],"most":[62],"phases":[63],"Becaplermin":[67],"(PDGF-BB),":[68],"only":[70],"approved":[73],"Food":[76],"Drug":[78],"Administration,":[79],"requires":[80],"daily":[81],"application":[82,100],"neuropathic":[84],"Gene":[87],"therapy":[88,161],"under":[90],"development":[91],"more":[93],"efficient":[94],"delivery;":[97],"a":[98,115,122,129],"single":[99],"will":[101],"induce":[102],"constitutive":[103],"expression":[106],"weeks.":[108],"Based":[109],"on":[110,121],"dramatic":[111],"preclinical":[112,146],"animal":[113],"studies,":[114],"1":[117],"clinical":[118,148],"trial":[119],"planned":[120],"genetic":[124],"construct":[125],"appears":[126],"promising.":[127],"Despite":[128],"slow":[130],"start,":[131],"have":[134],"great":[135],"therapeutic":[136],"potential":[137],"chronic":[139],"wounds.":[140],"This":[141],"literature":[142],"review":[143],"examines":[144],"notable":[145],"trials":[149],"topically":[151],"applied":[152],"looks":[156],"at":[157],"impact":[159],"gene":[160],"could":[162],"have.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}