{"id":"https://openalex.org/W2015168704","doi":null,"title":"[Oocyte activation with calcium ionophore A23187 and puromycin on human oocytes that fail to fertilize after intracytoplasmic sperm injection].","display_name":"[Oocyte activation with calcium ionophore A23187 and puromycin on human oocytes that fail to fertilize after intracytoplasmic sperm injection].","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2015168704","mag":"2015168704","pmid":"https://pubmed.ncbi.nlm.nih.gov/16640885"},"language":"zh","primary_location":{"id":"pmid:16640885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16640885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054280328","display_name":"Qun Lu","orcid":"https://orcid.org/0000-0002-5873-2146","observed_orcids":["https://orcid.org/0000-0002-5873-2146"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Lu","raw_affiliation_strings":["Reproductive Medicine Center, Shandong Provincial Hospital, Shandong University, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Shandong Provincial Hospital, Shandong University, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108064842","display_name":"Zi\u2010Jiang Chen","orcid":"https://orcid.org/0000-0001-6637-6631","observed_orcids":["https://orcid.org/0000-0001-6637-6631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zi-jiang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044683577","display_name":"Xuan Gao","orcid":"https://orcid.org/0000-0002-9437-389X","observed_orcids":["https://orcid.org/0000-0002-9437-389X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuan Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060607563","display_name":"Shuiying Ma","orcid":"https://orcid.org/0000-0001-8369-8421","observed_orcids":["https://orcid.org/0000-0001-8369-8421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shui-ying Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745803","display_name":"Mei Li","orcid":"https://orcid.org/0000-0002-1852-6567","observed_orcids":["https://orcid.org/0000-0002-1852-6567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038705570","display_name":"Jing-mei Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing-mei Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100721496","display_name":"Yuan Li","orcid":"https://orcid.org/0000-0002-1683-6801","observed_orcids":["https://orcid.org/0000-0002-1683-6801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6614,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73902299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"41","issue":"3","first_page":"182","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oocyte-activation","display_name":"oocyte activation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.9750000238418579},{"id":"https://openalex.org/keywords/puromycin","display_name":"puromycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.9190000295639038},{"id":"https://openalex.org/keywords/unfertilized-oocytes","display_name":"unfertilized oocytes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/human-oocytes","display_name":"human oocytes","score":0.6779999732971191},{"id":"https://openalex.org/keywords/in-vitro-maturation","display_name":"in vitro maturation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/pronucleus-formation","display_name":"pronuclear formation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/embryonic-cleavage","display_name":"embryo cleavage","score":0.7820000052452087},{"id":"https://openalex.org/keywords/embryo-sex-determination","display_name":"embryo sex determination","score":0.703000009059906},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.33000001311302185},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.4099999964237213},{"id":"https://openalex.org/keywords/embryo-culture-duration","display_name":"embryo culture duration","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C2778278907","wikidata":"https://www.wikidata.org/wiki/Q28700","display_name":"Intracytoplasmic sperm injection","level":4,"score":0.8842031359672546},{"id":"https://openalex.org/C179265757","wikidata":"https://www.wikidata.org/wiki/Q7095247","display_name":"Oocyte activation","level":4,"score":0.827804684638977},{"id":"https://openalex.org/C110758877","wikidata":"https://www.wikidata.org/wiki/Q2614103","display_name":"Pronucleus","level":5,"score":0.7787485718727112},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.7542946338653564},{"id":"https://openalex.org/C2779014961","wikidata":"https://www.wikidata.org/wiki/Q415168","display_name":"Ionophore","level":3,"score":0.620378851890564},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.5512675046920776},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.496338427066803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4930209815502167},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.49190855026245117},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.45222312211990356},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.38180845975875854},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.31654876470565796},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.31509286165237427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2861737310886383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23602184653282166},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21726858615875244},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.16955381631851196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.084217369556427},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002970","descriptor_name":"Cleavage Stage, Ovum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011691","descriptor_name":"Puromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015053","descriptor_name":"Zygote","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015053","descriptor_name":"Zygote","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015053","descriptor_name":"Zygote","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020554","descriptor_name":"Sperm Injections, Intracytoplasmic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16640885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16640885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"English Abstract"},{"id":"mag:2015168704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16640885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967784577","https://openalex.org/W2042255225","https://openalex.org/W4296983823","https://openalex.org/W2388531580","https://openalex.org/W2007140476","https://openalex.org/W2384414367","https://openalex.org/W2354526301","https://openalex.org/W3028731558","https://openalex.org/W1502340163","https://openalex.org/W7125685088"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,59,114,156,178,220,230,295],"effect":[4],"of":[5,36,129,170,199,204,210,229,263,283,294],"assisted":[6],"oocyte":[7],"activation":[8,126,200,224,289],"with":[9,105,174,250,255,267],"calcium":[10,94,171,264],"ionophore":[11,95,172,265],"A23187":[12,96,173,266],"and":[13,49,81,102,135,162,207,226,240,252,291,305],"puromycin":[14,106,175,268],"on":[15,155],"human":[16],"oocytes":[17,31,90,115,130,180,273,285],"that":[18,32,131,158,301],"fail":[19],"to":[20,54,58,93,219],"fertilize":[21],"after":[22,43,61,140,185,278,286],"intracytoplasmic":[23],"sperm":[24],"injection":[25],"(ICSI).":[26],"METHODS:":[27],"All":[28,88],"113":[29],"discarded":[30],"showed":[33,132,247],"no":[34],"evidence":[35],"fertilization":[37],"at":[38],"16":[39,258],"-":[40,122,182,275],"18":[41],"hours":[42,184,277],"in":[44,118,151,191,215,233,257],"vitro":[45,119],"maturation":[46],"(IVM)-ICSI":[47],"cycles":[48],"conventional":[50],"ICSI":[51,75,82,237,241,287],"were":[52,91,116,138,189],"assigned":[53],"four":[55],"groups":[56],"according":[57],"time":[60,282],"ICSI:":[62],"IVM-ICSI":[63,69,192,234],"22-hour":[64,193],"group":[65,71,77,84,217,239,243],"(n":[66,72,78,85],"=":[67,73,79,86],"33),":[68],"44-hour":[70,76,235,238],"18),":[74],"37)":[80],"68-hour":[83,242],"25).":[87],"unfertilized":[89,179,272,284],"exposed":[92],"(5":[97],"micromol/L)":[98],"for":[99,109,120],"5":[100,123],"minutes":[101],"subsequently":[103],"incubated":[104],"(10":[107],"microg/ml)":[108],"4":[110,248],"hours.":[111],"After":[112],"incubation,":[113],"cultured":[117,281],"3":[121],"days.":[124],"The":[125,168,223,261,280,298],"rate,":[127,201],"proportion":[128],"pronucleus":[133],"formation":[134],"cleavage":[136,205],"rate":[137,206,225],"calculated":[139],"activation.":[141],"Sex":[142],"chromosomal":[143],"analysis":[144,246],"was":[145],"performed":[146],"by":[147],"dual":[148],"color":[149],"fluorescence":[150],"situ":[152],"hybridization":[153],"(FISH)":[154],"embryos":[157,232,249,254],"displayed":[159],"two":[160,303],"pronuclei":[161,304],"a":[163,306],"second":[164,307],"polar":[165,308],"body.":[166],"RESULTS:":[167],"combination":[169,262],"could":[176,269],"activate":[177,271],"22":[181,274],"68":[183,276],"ICSI.":[186,279],"Best":[187],"results":[188],"achieved":[190],"group,":[194,236],"which":[195],"elicited":[196],"88%":[197],"(29/33)":[198],"62%":[202],"(18/29)":[203],"28%":[208],"(5/18)":[209],"4-cell":[211],"embryos.":[212,259,297],"One":[213],"embryo":[214],"this":[216],"developed":[218],"morular":[221],"stage.":[222],"developmental":[227,292],"potential":[228,293],"activated":[231,296,299],"decreased.":[244],"FISH":[245],"XX":[251],"9":[253],"XY":[256],"CONCLUSIONS:":[260],"effectively":[270],"affects":[288],"efficiency":[290],"zygotes":[300],"display":[302],"body":[309],"can":[310],"develop":[311],"normally.":[312]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
