{"id":"https://openalex.org/W2015157072","doi":"https://doi.org/10.1113/jphysiol.1972.sp009700","title":"A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium","display_name":"A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium","publication_year":1972,"publication_date":"1972-01-01","ids":{"openalex":"https://openalex.org/W2015157072","doi":"https://doi.org/10.1113/jphysiol.1972.sp009700","mag":"2015157072","pmid":"https://pubmed.ncbi.nlm.nih.gov/5059233","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1331695"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1972.sp009700","doi":"https://doi.org/10.1113/jphysiol.1972.sp009700","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1972.sp009700","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1331695","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110028304","display_name":"Chulani T. Kappagoda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. T. Kappagoda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108587559","display_name":"Ronald J. Linden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. J. Linden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087410088","display_name":"H. M. Snow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. M. Snow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":8.8806,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.97826276,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"220","issue":"1","first_page":"177","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superior-vena-cava","display_name":"superior vena cava","score":0.9210000038146973},{"id":"https://openalex.org/keywords/right-atrium","display_name":"right atrium","score":0.9850000143051147},{"id":"https://openalex.org/keywords/venous-distension","display_name":"venous distension","score":0.7599999904632568},{"id":"https://openalex.org/keywords/atrial-receptors","display_name":"atrial receptors","score":0.6380000114440918},{"id":"https://openalex.org/keywords/vagal-afferents","display_name":"vagal afferents","score":0.8080000281333923},{"id":"https://openalex.org/keywords/sympathetic-efferents","display_name":"sympathetic efferents","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cardiac-reflexes","display_name":"cardiac reflexes","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2776625112","wikidata":"https://www.wikidata.org/wiki/Q5282934","display_name":"Distension","level":2,"score":0.9251748323440552},{"id":"https://openalex.org/C2776512019","wikidata":"https://www.wikidata.org/wiki/Q1816418","display_name":"Efferent","level":3,"score":0.6599096059799194},{"id":"https://openalex.org/C2777001951","wikidata":"https://www.wikidata.org/wiki/Q1074839","display_name":"Right atrium","level":2,"score":0.6155422329902649},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.615095317363739},{"id":"https://openalex.org/C2908767450","wikidata":"https://www.wikidata.org/wiki/Q736995","display_name":"Superior vena cava","level":2,"score":0.6042588949203491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5926483869552612},{"id":"https://openalex.org/C47323905","wikidata":"https://www.wikidata.org/wiki/Q3506185","display_name":"Venous return curve","level":3,"score":0.5590255856513977},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5209911465644836},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4866426885128021},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.46268191933631897},{"id":"https://openalex.org/C114021368","wikidata":"https://www.wikidata.org/wiki/Q189265","display_name":"Atrium (architecture)","level":3,"score":0.46020999550819397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43897706270217896},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.42635029554367065},{"id":"https://openalex.org/C2910216633","wikidata":"https://www.wikidata.org/wiki/Q745438","display_name":"Inferior vena cava","level":2,"score":0.4252339005470276},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.15676695108413696},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.1484549343585968},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.12920624017715454}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001949","descriptor_name":"Bretylium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005263","descriptor_name":"Femoral Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008365","descriptor_name":"Manometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009476","descriptor_name":"Neurons, Efferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014683","descriptor_name":"Vena Cava, Superior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014690","descriptor_name":"Venous Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016275","descriptor_name":"Atrial Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1972.sp009700","doi":"https://doi.org/10.1113/jphysiol.1972.sp009700","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1972.sp009700","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1331695","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1331695","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:5059233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5059233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1331695","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1331695","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1971729333","https://openalex.org/W2004799361","https://openalex.org/W2005783780","https://openalex.org/W2016297895","https://openalex.org/W2028309496","https://openalex.org/W2045797647","https://openalex.org/W2048866290","https://openalex.org/W2056274829","https://openalex.org/W2071265389","https://openalex.org/W2083303602","https://openalex.org/W2087121409","https://openalex.org/W2094452259","https://openalex.org/W2097131409","https://openalex.org/W2116771015","https://openalex.org/W2155029067","https://openalex.org/W2155936208","https://openalex.org/W2160408590","https://openalex.org/W2160525275","https://openalex.org/W2164996315","https://openalex.org/W2273843043","https://openalex.org/W2295237965","https://openalex.org/W2326020098","https://openalex.org/W2328520316","https://openalex.org/W2341900767","https://openalex.org/W2411047004","https://openalex.org/W2412401284","https://openalex.org/W2413042587","https://openalex.org/W2424889284","https://openalex.org/W2426044314","https://openalex.org/W2427551807","https://openalex.org/W2471532416","https://openalex.org/W2597017250"],"related_works":["https://openalex.org/W2019946464","https://openalex.org/W2164996315","https://openalex.org/W2094452259","https://openalex.org/W2161766254","https://openalex.org/W2004799361","https://openalex.org/W2428629674","https://openalex.org/W1977922700","https://openalex.org/W2067271740","https://openalex.org/W2416477508","https://openalex.org/W2078390267"],"abstract_inverted_index":{"1.":[0],"Localized":[1],"distension":[2,58],"of":[3,59,81,85],"the":[4,7,12,34,39,42,46,57,60,63,68,72,78,82,86],"junction":[5,61],"between":[6,62],"superior":[8,64,87],"vena":[9,65,88],"cava":[10,66],"and":[11,41,67],"right":[13,69,73],"atrium":[14,70],"without":[15],"obstructing":[16],"venous":[17],"return":[18],"caused":[19],"an":[20],"increase":[21,26],"in":[22,27,38,45],"heart":[23,28],"rate.2.":[24],"This":[25],"rate":[29],"was":[30,37],"a":[31],"reflex":[32],"response;":[33],"afferent":[35],"path":[36],"vagi":[40],"efferent":[43],"solely":[44],"sympathetic":[47],"nerves.3.":[48],"The":[49],"receptors":[50,75],"most":[51],"likely":[52],"to":[53],"be":[54],"stimulated":[55],"by":[56],"are":[71],"atrial":[74,90],"located":[76],"on":[77],"endocardial":[79],"surface":[80],"intrapericardial":[83],"portion":[84],"caval-right":[89],"junction.":[91]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}