{"id":"https://openalex.org/W2015156262","doi":"https://doi.org/10.1016/j.tiv.2011.12.016","title":"Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility","display_name":"Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility","publication_year":2012,"publication_date":"2012-01-09","ids":{"openalex":"https://openalex.org/W2015156262","doi":"https://doi.org/10.1016/j.tiv.2011.12.016","mag":"2015156262","pmid":"https://pubmed.ncbi.nlm.nih.gov/22244922"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2011.12.016","doi":"https://doi.org/10.1016/j.tiv.2011.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2011.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109162124","display_name":"James Brian. Houston","orcid":"https://orcid.org/0000-0002-9322-0533","observed_orcids":["https://orcid.org/0000-0002-9322-0533","https://orcid.org/0000-0003-0962-0620"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. Brian Houston","raw_affiliation_strings":["Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom. brian.houston@manchester.ac.uk","Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom. brian.houston@manchester.ac.uk","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045719833","display_name":"K Rowland\u2010Yeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161181","display_name":"Simcyp (United Kingdom)","ror":"https://ror.org/02j65kc59","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210161181"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen Rowland-Yeo","raw_affiliation_strings":["Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, United Kingdom","institution_ids":["https://openalex.org/I4210161181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009359323","display_name":"Ugo Zanelli","orcid":"https://orcid.org/0000-0002-8942-412X","observed_orcids":["https://orcid.org/0000-0002-8942-412X"]},"institutions":[{"id":"https://openalex.org/I4210117667","display_name":"Siena Biotech (Italy)","ror":"https://ror.org/02ka1d450","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210117667"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ugo Zanelli","raw_affiliation_strings":["Met Profiling, Department of Screening and Technologies, Siena Biotech S.p.A., via del Petriccio e Belriguardo 35, 53100 Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Met Profiling, Department of Screening and Technologies, Siena Biotech S.p.A., via del Petriccio e Belriguardo 35, 53100 Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109162124"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.9818,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75346846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"8","first_page":"1265","last_page":"1271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.3617999851703644,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.3617999851703644,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.16660000383853912,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probe-compounds","display_name":"probe compounds","score":0.8629999756813049},{"id":"https://openalex.org/keywords/metabolic-competence","display_name":"metabolic competence","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cellular-integrity","display_name":"cell integrity","score":0.871999979019165},{"id":"https://openalex.org/keywords/predictive-utility","display_name":"predictive utility","score":0.5370000004768372},{"id":"https://openalex.org/keywords/model-compounds","display_name":"model compounds","score":0.7950000166893005},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4399999976158142},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5641221404075623},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4465333819389343},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.42526325583457947},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3674841821193695},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3294220566749573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19530659914016724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1645025610923767},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.09910407662391663},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08926290273666382},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.tiv.2011.12.016","doi":"https://doi.org/10.1016/j.tiv.2011.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2011.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:22244922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22244922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/b3de4b72-a499-4e71-8754-26e7aa49c62d","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/b3de4b72-a499-4e71-8754-26e7aa49c62d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Houston, J B, Rowland-Yeo, K & Zanelli, U 2012, 'Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility', Toxicology in Vitro, vol. 26, no. 8, pp. 1265-71. https://doi.org/10.1016/j.tiv.2011.12.016","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W68169567","https://openalex.org/W74649421","https://openalex.org/W1497221593","https://openalex.org/W1982755239","https://openalex.org/W2017983838","https://openalex.org/W2042506106","https://openalex.org/W2056455169","https://openalex.org/W2064799851","https://openalex.org/W2076546070","https://openalex.org/W2095319468","https://openalex.org/W2099474947","https://openalex.org/W2108458189","https://openalex.org/W2118872033","https://openalex.org/W2132047249","https://openalex.org/W2132603119","https://openalex.org/W2133032469","https://openalex.org/W2133105878","https://openalex.org/W2139964908","https://openalex.org/W2140084077","https://openalex.org/W2140178508","https://openalex.org/W2140474672","https://openalex.org/W2150823598","https://openalex.org/W2152923211","https://openalex.org/W2157870298","https://openalex.org/W2161213051","https://openalex.org/W2168398891","https://openalex.org/W2171534546","https://openalex.org/W2171671443","https://openalex.org/W2395369933"],"related_works":["https://openalex.org/W2025284778","https://openalex.org/W4220944232","https://openalex.org/W2028936105","https://openalex.org/W149557332","https://openalex.org/W2886557322","https://openalex.org/W4403588448","https://openalex.org/W1941354194","https://openalex.org/W1001064239","https://openalex.org/W2084606759","https://openalex.org/W7100828351"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}