{"id":"https://openalex.org/W2015152052","doi":"https://doi.org/10.1016/j.hfc.2010.12.003","title":"Role of Antiarrhythmic Drugs: Frequent Implantable Cardioverter-Defibrillator Shocks, Risk of Proarrhythmia, and New Drug Therapy","display_name":"Role of Antiarrhythmic Drugs: Frequent Implantable Cardioverter-Defibrillator Shocks, Risk of Proarrhythmia, and New Drug Therapy","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2015152052","doi":"https://doi.org/10.1016/j.hfc.2010.12.003","mag":"2015152052","pmid":"https://pubmed.ncbi.nlm.nih.gov/21439498"},"language":"en","primary_location":{"id":"doi:10.1016/j.hfc.2010.12.003","doi":"https://doi.org/10.1016/j.hfc.2010.12.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.hfc.2010.12.003","pdf_url":null,"source":{"id":"https://openalex.org/S174878270","display_name":"Heart Failure Clinics","issn_l":"1551-7136","issn":["1551-7136","2374-9334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Failure Clinics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072224754","display_name":"Christopher J. Droogan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313504624","display_name":"Main Line Health","ror":"https://ror.org/04rgsag55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313504624"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]},{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher Droogan","raw_affiliation_strings":["Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 356, Wynnewood, PA 19096, USA. drooganc@mlhs.org","Department of Cardiology, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 356, Wynnewood, PA 19096, USA","Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University Hospital, 111 South 11th Street, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 356, Wynnewood, PA 19096, USA. drooganc@mlhs.org","institution_ids":["https://openalex.org/I1313504624"]},{"raw_affiliation_string":"Department of Cardiology, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]},{"raw_affiliation_string":"Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 356, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I1313504624"]},{"raw_affiliation_string":"Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University Hospital, 111 South 11th Street, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2799360765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080400831","display_name":"Chinmay Patel","orcid":"https://orcid.org/0000-0002-2934-8786","observed_orcids":["https://orcid.org/0000-0002-2934-8786"]},"institutions":[{"id":"https://openalex.org/I1313504624","display_name":"Main Line Health","ror":"https://ror.org/04rgsag55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313504624"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinmay Patel","raw_affiliation_strings":["Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I1313504624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080084015","display_name":"Gan\u2010Xin Yan","orcid":"https://orcid.org/0000-0002-3118-5680","observed_orcids":["https://orcid.org/0000-0002-3118-5680"]},"institutions":[{"id":"https://openalex.org/I1313504624","display_name":"Main Line Health","ror":"https://ror.org/04rgsag55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313504624"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]},{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gan-Xin Yan","raw_affiliation_strings":["Department of Cardiology, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University Hospital, 111 South 11th Street, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]},{"raw_affiliation_string":"Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I1313504624"]},{"raw_affiliation_string":"Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University Hospital, 111 South 11th Street, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2799360765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001241147","display_name":"Peter Russell Kowey","orcid":"https://orcid.org/0000-0001-7189-1638","observed_orcids":["https://orcid.org/0000-0001-7189-1638"]},"institutions":[{"id":"https://openalex.org/I1313504624","display_name":"Main Line Health","ror":"https://ror.org/04rgsag55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313504624"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]},{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter R. Kowey","raw_affiliation_strings":["Department of Cardiology, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University Hospital, 111 South 11th Street, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]},{"raw_affiliation_string":"Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 558, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I1313504624"]},{"raw_affiliation_string":"Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University Hospital, 111 South 11th Street, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2799360765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072224754"],"corresponding_institution_ids":["https://openalex.org/I1313504624","https://openalex.org/I149251103","https://openalex.org/I182321934","https://openalex.org/I2799360765"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":null,"fwci":0.2113,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.20405819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"2","first_page":"195","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/implantable-cardioverter-defibrillator","display_name":"implantable cardioverter-defibrillator","score":0.9229999780654907},{"id":"https://openalex.org/keywords/icd-shocks","display_name":"ICD shocks","score":0.8259999752044678},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.9750000238418579},{"id":"https://openalex.org/keywords/drug-induced-arrhythmia","display_name":"drug-induced arrhythmia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8379999995231628},{"id":"https://openalex.org/keywords/sotalol","display_name":"sotalol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amiodarone","display_name":"amiodarone","score":1.0},{"id":"https://openalex.org/keywords/azimilide","display_name":"azimilide","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.890999972820282},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.8899999856948853},{"id":"https://openalex.org/keywords/supraventricular-arrhythmias","display_name":"supraventricular arrhythmias","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9686221480369568},{"id":"https://openalex.org/C2777008848","wikidata":"https://www.wikidata.org/wiki/Q7246836","display_name":"Proarrhythmia","level":3,"score":0.9555753469467163},{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.8910974264144897},{"id":"https://openalex.org/C2776639339","wikidata":"https://www.wikidata.org/wiki/Q413591","display_name":"Sotalol","level":3,"score":0.8529397249221802},{"id":"https://openalex.org/C2777093960","wikidata":"https://www.wikidata.org/wiki/Q594446","display_name":"Implantable cardioverter-defibrillator","level":2,"score":0.7022275924682617},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6558120846748352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5820834636688232},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.4996933937072754},{"id":"https://openalex.org/C2777561782","wikidata":"https://www.wikidata.org/wiki/Q420377","display_name":"Mexiletine","level":2,"score":0.4505208730697632},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.429055780172348},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.4153834879398346},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3839852809906006},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.26041480898857117},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.19640019536018372},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12221595644950867}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017147","descriptor_name":"Defibrillators, Implantable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.hfc.2010.12.003","doi":"https://doi.org/10.1016/j.hfc.2010.12.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.hfc.2010.12.003","pdf_url":null,"source":{"id":"https://openalex.org/S174878270","display_name":"Heart Failure Clinics","issn_l":"1551-7136","issn":["1551-7136","2374-9334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Failure Clinics","raw_type":"journal-article"},{"id":"pmid:21439498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21439498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart failure clinics","raw_type":"Journal Article"},{"id":"pmh:oai:jdc.jefferson.edu:medfp-1077","doi":null,"is_oa":false,"landing_page_url":"https://jdc.jefferson.edu/medfp/53","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Medicine Faculty Papers","raw_type":"article"},{"id":"mag:2483821080","doi":null,"is_oa":false,"landing_page_url":"https://www.heartfailure.theclinics.com/article/S1551-7136(10)00133-9/pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W37135593","https://openalex.org/W93907487","https://openalex.org/W161121640","https://openalex.org/W229233559","https://openalex.org/W1505375105","https://openalex.org/W1981025912","https://openalex.org/W1981919609","https://openalex.org/W1981964073","https://openalex.org/W1985277411","https://openalex.org/W1986336067","https://openalex.org/W1986843348","https://openalex.org/W1987539123","https://openalex.org/W1988814768","https://openalex.org/W1998487877","https://openalex.org/W1999349447","https://openalex.org/W2002864523","https://openalex.org/W2008559341","https://openalex.org/W2009887763","https://openalex.org/W2010778759","https://openalex.org/W2014177473","https://openalex.org/W2016958168","https://openalex.org/W2026225505","https://openalex.org/W2030786785","https://openalex.org/W2033536203","https://openalex.org/W2033778430","https://openalex.org/W2047448176","https://openalex.org/W2053060792","https://openalex.org/W2055864381","https://openalex.org/W2060605213","https://openalex.org/W2061361200","https://openalex.org/W2066371755","https://openalex.org/W2069645043","https://openalex.org/W2075175982","https://openalex.org/W2091984080","https://openalex.org/W2098335122","https://openalex.org/W2102156052","https://openalex.org/W2108304318","https://openalex.org/W2115951287","https://openalex.org/W2117048956","https://openalex.org/W2118214230","https://openalex.org/W2119818163","https://openalex.org/W2121258303","https://openalex.org/W2121290795","https://openalex.org/W2125455490","https://openalex.org/W2127242612","https://openalex.org/W2129316398","https://openalex.org/W2136518010","https://openalex.org/W2139803224","https://openalex.org/W2143944190","https://openalex.org/W2147134314","https://openalex.org/W2156243767","https://openalex.org/W2546907931","https://openalex.org/W2580776676","https://openalex.org/W2900850603","https://openalex.org/W4251530540"],"related_works":["https://openalex.org/W2073124752","https://openalex.org/W2924145984","https://openalex.org/W334165867","https://openalex.org/W2084892644","https://openalex.org/W2000529202","https://openalex.org/W2077377551","https://openalex.org/W2071380692","https://openalex.org/W2064087590","https://openalex.org/W2147911859","https://openalex.org/W1979272850"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}