{"id":"https://openalex.org/W2015148142","doi":"https://doi.org/10.1002/ijc.27918","title":"Cytotoxic and immune\u2010mediated killing of human colorectal cancer by reovirus\u2010loaded blood and liver mononuclear cells","display_name":"Cytotoxic and immune\u2010mediated killing of human colorectal cancer by reovirus\u2010loaded blood and liver mononuclear cells","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2015148142","doi":"https://doi.org/10.1002/ijc.27918","mag":"2015148142","pmid":"https://pubmed.ncbi.nlm.nih.gov/23114986","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891508"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.27918","doi":"https://doi.org/10.1002/ijc.27918","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.27918","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3891508","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113497399","display_name":"Robert A. Adair","orcid":"https://orcid.org/0000-0002-5639-7081","observed_orcids":["https://orcid.org/0000-0002-5639-7081"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert A. Adair","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","R.A.A. and K.J.S. contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"R.A.A. and K.J.S. contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000089296","display_name":"Karen J. Scott","orcid":"https://orcid.org/0000-0002-5790-9579","observed_orcids":["https://orcid.org/0000-0002-5790-9579"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen J. Scott","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","R.A.A. and K.J.S. contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"R.A.A. and K.J.S. contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009666375","display_name":"Sheila Fraser","orcid":"https://orcid.org/0000-0002-2299-8778","observed_orcids":["https://orcid.org/0000-0002-2299-8778"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sheila Fraser","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046824020","display_name":"Fiona Errington\u2010Mais","orcid":"https://orcid.org/0000-0003-2155-534X","observed_orcids":["https://orcid.org/0000-0003-2155-534X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fiona Errington\u2010Mais","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067211956","display_name":"Hardev Pandha","orcid":"https://orcid.org/0000-0002-9420-7701","observed_orcids":["https://orcid.org/0000-0002-9420-7701"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hardev Pandha","raw_affiliation_strings":["Leggett Building, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leggett Building, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078521568","display_name":"Matt C. Coffey","orcid":"https://orcid.org/0000-0002-7211-829X","observed_orcids":["https://orcid.org/0000-0002-7211-829X"]},"institutions":[{"id":"https://openalex.org/I874317431","display_name":"Oncolytics Biotech (Canada)","ror":"https://ror.org/05phqqn85","country_code":"CA","type":"company","lineage":["https://openalex.org/I874317431"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matt Coffey","raw_affiliation_strings":["Oncolytics Biotech Incorporated, Calgary, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncolytics Biotech Incorporated, Calgary, Canada","institution_ids":["https://openalex.org/I874317431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086212361","display_name":"Peter John Selby","orcid":"https://orcid.org/0000-0002-3782-069X","observed_orcids":["https://orcid.org/0000-0002-3782-069X","https://orcid.org/0000-0001-5401-2996","https://orcid.org/0000-0001-9465-9268"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Selby","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003708582","display_name":"Graham P. Cook","orcid":"https://orcid.org/0000-0003-0223-3652","observed_orcids":["https://orcid.org/0000-0003-0223-3652"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham P. Cook","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070554485","display_name":"Richard G. Vile","orcid":"https://orcid.org/0000-0003-2192-9372","observed_orcids":["https://orcid.org/0000-0003-2192-9372"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Richard Vile","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","Molecular Medicine Program and Department of Immunology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Molecular Medicine Program and Department of Immunology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072284989","display_name":"Kevin Joseph Harrington","orcid":"https://orcid.org/0000-0002-6014-348X","observed_orcids":["https://orcid.org/0000-0002-6014-348X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin J. Harrington","raw_affiliation_strings":["Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007919521","display_name":"Giles J. Toogood","orcid":"https://orcid.org/0000-0003-4535-6249","observed_orcids":["https://orcid.org/0000-0003-4535-6249"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giles Toogood","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069116024","display_name":"Alan A. Melcher","orcid":"https://orcid.org/0000-0002-2042-3380","observed_orcids":["https://orcid.org/0000-0002-2042-3380"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alan A. Melcher","raw_affiliation_strings":["Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","Tel.: 0113 343 8456,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Tel.: 0113 343 8456,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5069116024"],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":3.2282,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.92926704,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"132","issue":"10","first_page":"2327","last_page":"2338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reovirus","display_name":"reovirus","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/liver-mononuclear-cells","display_name":"liver mononuclear cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.6710000038146973},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8429999947547913},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.703000009059906},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7520366907119751},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.7446357011795044},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6820976734161377},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6781885623931885},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5709816217422485},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.536514937877655},{"id":"https://openalex.org/C206191192","wikidata":"https://www.wikidata.org/wiki/Q17149636","display_name":"NK-92","level":5,"score":0.4723972976207733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45176345109939575},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44141292572021484},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4328627586364746},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4124809503555298},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2607768177986145},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.19038274884223938},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.18055912852287292},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06029242277145386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012087","descriptor_name":"Reoviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1002/ijc.27918","doi":"https://doi.org/10.1002/ijc.27918","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.27918","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:23114986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23114986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2877272","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3891508","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3891508","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3891508/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Cancer","raw_type":"Text"},{"id":"pmh:oai:alma.44SUR_INST:11138959990002346","doi":null,"is_oa":false,"landing_page_url":"https://openresearch.surrey.ac.uk/esploro/outputs/journalArticle/Cytotoxic-and-immune-mediated-killing-of-human/99512798602346","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:epubs.surrey.ac.uk:825144","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/825144/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2877272","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3891508","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1425549394","display_name":null,"funder_award_id":"13244","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4387789583","display_name":"Immune Cell Carriers for the Delivery of Oncolytic Viruses to Metastatic Tumors","funder_award_id":"R01CA107082","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1484464171","https://openalex.org/W1854596437","https://openalex.org/W1969063827","https://openalex.org/W1987427709","https://openalex.org/W1996515420","https://openalex.org/W2004030192","https://openalex.org/W2004734349","https://openalex.org/W2008658418","https://openalex.org/W2016149207","https://openalex.org/W2024557213","https://openalex.org/W2028577286","https://openalex.org/W2029055826","https://openalex.org/W2064379047","https://openalex.org/W2079528891","https://openalex.org/W2080273948","https://openalex.org/W2092601545","https://openalex.org/W2099657083","https://openalex.org/W2102833781","https://openalex.org/W2103156714","https://openalex.org/W2103437371","https://openalex.org/W2110410873","https://openalex.org/W2118845971","https://openalex.org/W2118852328","https://openalex.org/W2122170158","https://openalex.org/W2126383453","https://openalex.org/W2128892990","https://openalex.org/W2135686776","https://openalex.org/W2139397653","https://openalex.org/W2144445863","https://openalex.org/W2151241812","https://openalex.org/W2158427957","https://openalex.org/W2419758366","https://openalex.org/W2424125503"],"related_works":["https://openalex.org/W1572868754","https://openalex.org/W2103437371","https://openalex.org/W2185160665","https://openalex.org/W2578704408","https://openalex.org/W2407340489","https://openalex.org/W2080273948","https://openalex.org/W2899965137","https://openalex.org/W2144445863","https://openalex.org/W2755688921","https://openalex.org/W2128892990"],"abstract_inverted_index":{"Reovirus":[0],"is":[1],"a":[2,145],"promising":[3],"oncolytic":[4,123],"virus,":[5],"acting":[6],"by":[7,19,37,84,165,173],"both":[8,191],"direct":[9,80,122,192],"and":[10,40,181,193],"immune-mediated":[11,195],"mechanisms,":[12],"although":[13],"its":[14],"potential":[15,188],"may":[16,107,170],"be":[17,32],"limited":[18],"inactivation":[20],"after":[21,110],"systemic":[22],"delivery.":[23],"Our":[24],"study":[25],"addressed":[26],"whether":[27,41],"systemically":[28],"delivered":[29],"reovirus":[30,67,96,169],"might":[31],"shielded":[33],"from":[34],"neutralising":[35,94],"antibodies":[36],"cell":[38,82,184],"carriage":[39,185],"virus-loaded":[42],"blood":[43,103,131,183],"or":[44,200],"hepatic":[45],"innate":[46,194],"immune":[47],"effector":[48],"cells":[49,56,73,128,133,152,156,162],"become":[50],"activated":[51,164],"to":[52,58,136,177,189,204],"kill":[53,137],"colorectal":[54,199],"cancer":[55],"metastatic":[57,203],"the":[59,91,187,205],"liver":[60,154],"in":[61,90,113,144],"human":[62,198],"systems.":[63],"We":[64],"found":[65],"that":[66],"was":[68,87,97],"directly":[69],"cytotoxic":[70,159],"against":[71,76,197],"tumour":[72,81,138,161],"but":[74,140],"not":[75,141],"fresh":[77],"hepatocytes.":[78],"Although":[79],"killing":[83],"neat":[85],"virus":[86,109,120],"significantly":[88],"reduced":[89],"presence":[92],"of":[93],"serum,":[95],"protected":[98],"when":[99,163],"loaded":[100],"onto":[101],"peripheral":[102],"mononuclear":[104,132,155,179],"cells,":[105,180],"which":[106],"carry":[108],"intravenous":[111,168],"administration":[112],"patients.":[114],"As":[115],"well":[116],"as":[117],"handing":[118],"off":[119],"for":[121],"killing,":[124],"natural":[125],"killer":[126],"(NK)":[127],"within":[129,153],"reovirus-treated":[130],"were":[134],"stimulated":[135],"targets,":[139],"normal":[142],"hepatocytes,":[143],"Type":[146],"I":[147],"interferon-dependent":[148],"manner.":[149],"Similarly,":[150],"NK":[151],"became":[157],"selectively":[158],"towards":[160],"reovirus.":[166],"Hence,":[167],"evade":[171],"neutralisation":[172],"serum":[174],"via":[175],"binding":[176],"circulating":[178],"this":[182],"has":[186],"investigate":[190],"therapy":[196],"other":[201],"cancers":[202],"liver.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
