{"id":"https://openalex.org/W2015146945","doi":"https://doi.org/10.1097/00001721-199907000-00008","title":"Lipid-lowering therapy corrects endothelial cell dysfunction in a short time but does not affect hypercoagulable state even after long-term use in hyperlipidemic patients","display_name":"Lipid-lowering therapy corrects endothelial cell dysfunction in a short time but does not affect hypercoagulable state even after long-term use in hyperlipidemic patients","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2015146945","doi":"https://doi.org/10.1097/00001721-199907000-00008","mag":"2015146945","pmid":"https://pubmed.ncbi.nlm.nih.gov/10456618"},"language":"en","primary_location":{"id":"doi:10.1097/00001721-199907000-00008","doi":"https://doi.org/10.1097/00001721-199907000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001721-199907000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation &amp; Fibrinolysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017863780","display_name":"Kazuomi Kario","orcid":"https://orcid.org/0000-0002-8251-4480","observed_orcids":["https://orcid.org/0000-0002-8251-4480"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"K. Kario","raw_affiliation_strings":["Department of Cardiology, Jichi Medical School, Tochigi, Japan. kak2012@mail.med.cornell.edu","K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Jichi Medical School, Tochigi, Japan. kak2012@mail.med.cornell.edu","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]},{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"T. Matsuo","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058572301","display_name":"Satoshi Hoshide","orcid":"https://orcid.org/0000-0001-7541-5751","observed_orcids":["https://orcid.org/0000-0001-7541-5751"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"S. Hoshide","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039388112","display_name":"Hitomi Kobayashi","orcid":"https://orcid.org/0000-0002-0282-7074","observed_orcids":["https://orcid.org/0000-0002-0282-7074"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"H. Kobayashi","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Sakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"T. Sakata","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034691133","display_name":"Osamu Mizuno","orcid":"https://orcid.org/0000-0001-8061-7657","observed_orcids":["https://orcid.org/0000-0001-8061-7657","https://orcid.org/0000-0002-9731-9258"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"O. Mizuno","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113957498","display_name":"Toshitake Mitsuhashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"T. Mitsuhashi","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":null,"display_name":"U. Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"U. Ikeda","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069692585","display_name":"Tetsuro Miyata","orcid":"https://orcid.org/0000-0002-2893-9744","observed_orcids":["https://orcid.org/0000-0002-2893-9744"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"T. Miyata","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111475759","display_name":"Kentarou SHIMADA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"K. Shimada","raw_affiliation_strings":["K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Kario is with the Hypertension Center, The New York Hospital/Cornell University Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sponsorship: This study was supported completely by grants-in-aid (K.K.) from the Foundation for the Development of the Community (Tochigi, Japan). K. Kario, S. Hoshide, Y. O. Mizuno, T. Mitsuhashi, U. Ikeda, and K Shimada are with the Department of Cardiology, Jichi Medical School, Tochigi","institution_ids":[]},{"raw_affiliation_string":"T. Matsuo and H. Kobayashi are with the Department of Internal Medicine and Central Laboratory, Hyogo Prefect Hral Awaji Hospital, Sumoto, Hyogo","institution_ids":["https://openalex.org/I4210097704"]},{"raw_affiliation_string":"T. Sakata and T. Miyata are with the Research Institute and the Clinical Laboratory, National Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4442,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.82702685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"5","first_page":"269","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/factor-vii","display_name":"factor VII","score":0.7409999966621399},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.8769999742507935},{"id":"https://openalex.org/keywords/prothrombin-fragment-1-2","display_name":"prothrombin fragment 1+2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6309999823570251},{"id":"https://openalex.org/keywords/coronary-atherosclerosis-regression","display_name":"coronary atherosclerosis regression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.47999998927116394},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.5339999794960022},{"id":"https://openalex.org/keywords/fibrinolytic-activity","display_name":"fibrinolytic activity","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.9454752206802368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8434985876083374},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.765826940536499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7419565916061401},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6108155846595764},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6046460866928101},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5573319792747498},{"id":"https://openalex.org/C2780930249","wikidata":"https://www.wikidata.org/wiki/Q412850","display_name":"Factor VII","level":3,"score":0.5261948704719543},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.5151268243789673},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4907008409500122},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.4792214035987854},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.4634663164615631},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.45805418491363525},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.4354499280452728},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.4353767931461334},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4173663258552551},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36668717861175537},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2640773057937622},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1008637547492981}],"mesh":[{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001721-199907000-00008","doi":"https://doi.org/10.1097/00001721-199907000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001721-199907000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation &amp; Fibrinolysis","raw_type":"journal-article"},{"id":"pmid:10456618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10456618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087014659","https://openalex.org/W96518285","https://openalex.org/W29778464","https://openalex.org/W7099985946","https://openalex.org/W7096578450","https://openalex.org/W1973547693","https://openalex.org/W2007704497","https://openalex.org/W2036370600","https://openalex.org/W2381528956","https://openalex.org/W2382256057"],"abstract_inverted_index":{"Lipid-lowering":[0],"therapy":[1,152,193,240,303],"reduces":[2],"cardiac":[3,310],"events":[4,311],"to":[5,11,184,306],"an":[6],"extent":[7],"that":[8,278],"is":[9],"disproportionate":[10],"the":[12,27,35,133,270,307],"small":[13],"degree":[14],"of":[15,17,29,47,66,99,150,176,191,204,214,216,226,243,257,273],"regression":[16],"coronary":[18],"atherosclerosis":[19],"observed":[20],"among":[21],"hyperlipidemic":[22,42,87,112,138,291,319],"patients.":[23,43,253,292,320],"We":[24,44,131,276],"prospectively":[25],"investigated":[26],"effects":[28],"lipid":[30,279],"reduction":[31,196,280,308],"using":[32,281],"simvastatin":[33,151,192,217,239,274,282],"on":[34],"endothelial":[36,78,284,296],"dysfunction":[37,80,286],"and":[38,62,64,77,92,106,120,141,147,153,165,168,194,241,262],"hypercoagulability":[39,289],"found":[40],"in":[41,85,111,125,129,136,159,251,290,295,309,318],"measured":[45,132],"levels":[46,98,122,250,256],"coagulation":[48,67],"factors":[49],"[factor":[50],"VII":[51],"(FVII)":[52],"coagulant":[53],"activity":[54],"(FVIIc),":[55],"FVII":[56,60],"antigen":[57],"(FVIIAg),":[58],"activated":[59],"(FVIIa),":[61],"fibrinogen],":[63],"markers":[65],"activation":[68],"[prothrombin":[69],"fragment":[70],"1":[71,189,212],"+":[72,75,104,118,264],"2":[73,199,236,265,271],"(F1":[74],"2)]":[76],"cell":[79,285,297],"[von":[81],"Willebrand":[82],"factor":[83],"(vWF)]":[84],"20":[86,89,93],"patients,":[88,91,113],"hypertensive":[90,126,161,252],"normotensive":[94],"normolipidemic":[95],"controls.":[96,130],"The":[97,171,201,293],"FVIIa,":[100,116,261],"FVIIc,":[101,259],"FVIIAg,":[102,260],"F1":[103,117,263],"2,":[105,119],"vWF":[107,121,205],"were":[108,123,246],"all":[109],"higher":[110,124],"but":[114,220,287],"only":[115],"patients":[127,139,162],"than":[128],"above":[134],"parameters":[135],"13":[137],"before":[140],"after":[142,166,188,211,223],"1,":[143],"3,":[144],"6,":[145],"12":[146,167],"24":[148,169],"months":[149,225],"compared":[154,248],"these":[155,244],"values":[156],"with":[157,249],"those":[158],"15":[160],"at":[163],"baseline":[164],"months.":[170],"median":[172],"(25th-75th":[173],"percentile)":[174],"level":[175,203],"total":[177],"cholesterol":[178],"was":[179,208,221],"decreased":[180,222],"from":[181],"259":[182],"(255-278)":[183],"206":[185],"(176-220)":[186],"mg/dl":[187],"month":[190,213],"this":[195],"persisted":[197,234],"for":[198,235],"years.":[200],"plasma":[202],"[136%":[206],"(113-158%)]":[207],"not":[209,267,288],"changed":[210],"administration":[215],"[132%":[218],"(115-153%)],":[219],"3":[224],"treatment":[227],"[114%":[228],"(96-128%),":[229],"P<0.01].":[230],"This":[231],"decrease":[232],"also":[233],"years":[237,272],"during":[238],"both":[242],"reductions":[245],"significant,":[247],"In":[254],"contrast,":[255],"fibrinogen,":[258],"did":[266],"change":[268],"throughout":[269],"therapy.":[275],"conclude":[277],"corrects":[283],"improvement":[294],"function":[298],"brought":[299],"about":[300],"by":[301],"lipid-lowering":[302],"might":[304],"contribute":[305],"within":[312],"a":[313],"relatively":[314],"short":[315],"time":[316],"period":[317]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}