{"id":"https://openalex.org/W2015146751","doi":"https://doi.org/10.1210/jcem-15-11-1315","title":"A NEW SERUM IODINE COMPONENT IN PATIENTS WITH FUNCTIONAL CARCINOMA OF THE THYROID*\u2020","display_name":"A NEW SERUM IODINE COMPONENT IN PATIENTS WITH FUNCTIONAL CARCINOMA OF THE THYROID*\u2020","publication_year":1955,"publication_date":"1955-11-01","ids":{"openalex":"https://openalex.org/W2015146751","doi":"https://doi.org/10.1210/jcem-15-11-1315","mag":"2015146751","pmid":"https://pubmed.ncbi.nlm.nih.gov/13271519"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-15-11-1315","doi":"https://doi.org/10.1210/jcem-15-11-1315","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-15-11-1315","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111678245","display_name":"JACOB JOHN ROBBINS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JACOB ROBBINS","raw_affiliation_strings":["Memorial Center for Cancer and Allied Diseases New York 21, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Center for Cancer and Allied Diseases New York 21, N. Y","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110348881","display_name":"J. Edward Rall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. E. RALL","raw_affiliation_strings":["Memorial Center for Cancer and Allied Diseases New York 21, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Center for Cancer and Allied Diseases New York 21, N. Y","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113686478","display_name":"Rulon W. Rawson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RULON W. RAWSON","raw_affiliation_strings":["Memorial Center for Cancer and Allied Diseases New York 21, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Center for Cancer and Allied Diseases New York 21, N. Y","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":8.4532,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.97562037,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"11","first_page":"1315","last_page":"1331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.20679999887943268,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-iodine","display_name":"serum iodine","score":0.7200000286102295},{"id":"https://openalex.org/keywords/radioiodine","display_name":"radioactive iodine","score":0.8109999895095825},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.6449999809265137},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/iodide-metabolism","display_name":"iodide metabolism","score":0.6399999856948853},{"id":"https://openalex.org/keywords/iodine-131","display_name":"iodine-131","score":0.6069999933242798},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.5870000123977661},{"id":"https://openalex.org/keywords/serum-protein-electrophoresis","display_name":"serum protein electrophoresis","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7576742172241211},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.7510124444961548},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.7005906105041504},{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.6886911392211914},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6759991645812988},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6592459678649902},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.611248254776001},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.5916668176651001},{"id":"https://openalex.org/C158479217","wikidata":"https://www.wikidata.org/wiki/Q2352460","display_name":"Wolff\u2013Chaikoff effect","level":4,"score":0.5786297917366028},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5249171853065491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4906805753707886},{"id":"https://openalex.org/C2778870691","wikidata":"https://www.wikidata.org/wiki/Q44794658","display_name":"Iodide","level":2,"score":0.445330947637558},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.4297259449958801},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42087921500205994},{"id":"https://openalex.org/C2776254400","wikidata":"https://www.wikidata.org/wiki/Q165135","display_name":"Goiter","level":3,"score":0.41519543528556824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4119938313961029},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-15-11-1315","doi":"https://doi.org/10.1210/jcem-15-11-1315","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-15-11-1315","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:13271519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13271519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1519559444","https://openalex.org/W1580809633","https://openalex.org/W2055935149","https://openalex.org/W2103706286","https://openalex.org/W2037638436","https://openalex.org/W2087127909","https://openalex.org/W2326537263","https://openalex.org/W1971770545","https://openalex.org/W2418209380","https://openalex.org/W1966823787"],"abstract_inverted_index":{"CERTAIN":[0],"carcinomas":[1],"of":[2,10,61,78,104,115,121,126,149,156,222],"the":[3,8,24,40,59,75,79,105,127,150,154,167,208],"thyroid":[4,12,63,158,172,194],"in":[5,58,69,98,130,142,153,189,201],"man":[6],"acquire":[7],"function":[9],"normal":[11,62,131,157,176,202],"tissue":[13,159],"with":[14,51,101,146,193],"respect":[15],"to":[16,26,31,44,48,199],"iodine":[17,38,129,215],"metabolism":[18],"(1,":[19],"2).":[20],"Such":[21],"tumors":[22,85],"have":[23,138,183],"ability":[25],"concentrate":[27],"iodide,":[28],"convert":[29],"it":[30],"organic":[32],"form,":[33],"and":[34,47,111,118,132,228],"secrete":[35],"organically":[36],"bound":[37],"into":[39,166],"blood.":[41],"They":[42],"respond":[43],"thyrotropic":[45],"hormone":[46],"goitrogenic":[49],"drugs":[50],"an":[52],"increased":[53],"avidity":[54],"for":[55],"iodide":[56],"and,":[57],"absence":[60,155],"tissue,":[64],"may":[65],"maintain":[66],"their":[67],"hosts":[68],"a":[70,185,212],"euthyroid":[71],"state.":[72],"Observations":[73],"on":[74,95],"chemical":[76],"nature":[77,230],"iodinated":[80],"compounds":[81,137],"elaborated":[82],"by":[83],"these":[84],"have,":[86],"however,":[87,211],"been":[88,140,164,218],"scanty.":[89],"The":[90,220],"present":[91,209],"report":[92],"concerns":[93],"studies":[94],"serum":[96,143,190,214],"radioiodine":[97],"23":[99],"patients":[100,145,192],"functional":[102,147],"carcinoma":[103,148,173],"thyroid,":[106],"following":[107],"13":[108],"tracer":[109],"doses":[110,114],"37":[112],"therapeutic":[113],"I131.":[116],"Thyroxine,":[117],"small":[119],"amounts":[120],"triiodothyronine,":[122],"constitute":[123],"essentially":[124],"all":[125],"circulating":[128],"hyperthyroid":[133,204],"individuals":[134],"(3\u20136).":[135],"These":[136],"also":[139],"demonstrated":[141],"from":[144,169,191],"thyorid,":[151],"even":[152],"(7\u20139).":[160],"Thyroglobulin":[161],"which":[162,196],"has":[163,217],"discharged":[165],"blood":[168],"intensively":[170],"irradiated":[171],"likewise":[174],"resembles":[175],"thyroglobulin":[177],"(8\u201311).":[178],"Investigations":[179],"employing":[180],"zone":[181],"electrophoresis":[182],"revealed":[184],"specific":[186],"thyroxine-binding":[187],"protein":[188],"carcinoma,":[195],"is":[197],"similar":[198],"that":[200],"or":[203],"subjects":[205],"(11\u201316).":[206],"In":[207],"study,":[210],"new":[213],"component":[216],"found.":[219],"characteristics":[221],"this":[223],"abnormality":[224],"will":[225],"be":[226],"described,":[227],"its":[229],"discussed.":[231]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}