{"id":"https://openalex.org/W2015137678","doi":"https://doi.org/10.1039/c4nr00595c","title":"Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies","display_name":"Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2015137678","doi":"https://doi.org/10.1039/c4nr00595c","mag":"2015137678","pmid":"https://pubmed.ncbi.nlm.nih.gov/24777583"},"language":"en","primary_location":{"id":"doi:10.1039/c4nr00595c","doi":"https://doi.org/10.1039/c4nr00595c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4nr00595c","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2014/nr/c4nr00595c","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2014/nr/c4nr00595c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025577541","display_name":"Kristof Zarschler","orcid":"https://orcid.org/0000-0002-7571-4732","observed_orcids":["https://orcid.org/0000-0002-7571-4732"]},"institutions":[{"id":"https://openalex.org/I2801798921","display_name":"Helmholtz-Zentrum Dresden-Rossendorf","ror":"https://ror.org/01zy2cs03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801798921"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Zarschler","raw_affiliation_strings":["D-01328 Dresden, Germany","Helmholtz-Zentrum Dresden-Rossendorf","Institute of Radiopharmaceutical Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D-01328 Dresden, Germany","institution_ids":[]},{"raw_affiliation_string":"Helmholtz-Zentrum Dresden-Rossendorf","institution_ids":["https://openalex.org/I2801798921"]},{"raw_affiliation_string":"Institute of Radiopharmaceutical Cancer Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002990237","display_name":"Kanlaya Prapainop Katewongsa","orcid":"https://orcid.org/0000-0001-6417-4921","observed_orcids":["https://orcid.org/0000-0001-6417-4921"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"K. Prapainop","raw_affiliation_strings":["Belfield, Ireland","Centre For BioNano Interactions (CBNI)","School of Chemistry and Chemical Biology","University College Dublin","Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belfield, Ireland","institution_ids":[]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI)","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"University College Dublin","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065357816","display_name":"Eugene Mahon","orcid":"https://orcid.org/0000-0002-5170-6332","observed_orcids":["https://orcid.org/0000-0002-5170-6332"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"E. Mahon","raw_affiliation_strings":["Belfield, Ireland","Centre For BioNano Interactions (CBNI)","School of Chemistry and Chemical Biology","University College Dublin","Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belfield, Ireland","institution_ids":[]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI)","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"University College Dublin","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073568154","display_name":"Louise Rocks","orcid":"https://orcid.org/0000-0002-1870-4212","observed_orcids":["https://orcid.org/0000-0002-1870-4212"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"L. Rocks","raw_affiliation_strings":["Belfield, Ireland","Centre For BioNano Interactions (CBNI)","School of Chemistry and Chemical Biology","University College Dublin","Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belfield, Ireland","institution_ids":[]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI)","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"University College Dublin","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010831738","display_name":"Mattia Bramini","orcid":"https://orcid.org/0000-0002-0381-9391","observed_orcids":["https://orcid.org/0000-0002-0381-9391"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M. Bramini","raw_affiliation_strings":["Belfield, Ireland","Centre For BioNano Interactions (CBNI)","School of Chemistry and Chemical Biology","University College Dublin","Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belfield, Ireland","institution_ids":[]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI)","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"University College Dublin","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040613645","display_name":"Philip M. Kelly","orcid":"https://orcid.org/0000-0001-8933-2367","observed_orcids":["https://orcid.org/0000-0001-8933-2367"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"P. M. Kelly","raw_affiliation_strings":["Belfield, Ireland","Centre For BioNano Interactions (CBNI)","School of Chemistry and Chemical Biology","University College Dublin","Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belfield, Ireland","institution_ids":[]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI)","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"University College Dublin","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010748930","display_name":"Holger Stephan","orcid":"https://orcid.org/0000-0002-2972-2803","observed_orcids":["https://orcid.org/0000-0002-2972-2803"]},"institutions":[{"id":"https://openalex.org/I2801798921","display_name":"Helmholtz-Zentrum Dresden-Rossendorf","ror":"https://ror.org/01zy2cs03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801798921"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"H. Stephan","raw_affiliation_strings":["D-01328 Dresden, Germany","Helmholtz-Zentrum Dresden-Rossendorf","Institute of Radiopharmaceutical Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D-01328 Dresden, Germany","institution_ids":[]},{"raw_affiliation_string":"Helmholtz-Zentrum Dresden-Rossendorf","institution_ids":["https://openalex.org/I2801798921"]},{"raw_affiliation_string":"Institute of Radiopharmaceutical Cancer Research","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036495855","display_name":"Kenneth A. Dawson","orcid":"https://orcid.org/0000-0002-0568-6588","observed_orcids":["https://orcid.org/0000-0002-0568-6588"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"K. A. Dawson","raw_affiliation_strings":["Belfield, Ireland","Centre For BioNano Interactions (CBNI)","School of Chemistry and Chemical Biology","University College Dublin","Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belfield, Ireland","institution_ids":[]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI)","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"University College Dublin","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin,Belfield,Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010748930","https://openalex.org/A5036495855"],"corresponding_institution_ids":["https://openalex.org/I100930933","https://openalex.org/I2801798921"],"apc_list":null,"apc_paid":null,"fwci":4.3236,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.95437299,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"11","first_page":"6046","last_page":"6056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticle-targeting","display_name":"nanoparticle targeting","score":0.8199999928474426},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nanobodies","display_name":"nanobodies","score":0.9409999847412109},{"id":"https://openalex.org/keywords/camelid-antibodies","display_name":"camelid antibodies","score":0.753000020980835},{"id":"https://openalex.org/keywords/peptide-ligands","display_name":"peptide ligands","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tumour-biomarkers","display_name":"tumour biomarkers","score":0.6779999732971191},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.6449999809265137},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5910000205039978},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2777820669","wikidata":"https://www.wikidata.org/wiki/Q408338","display_name":"Single-domain antibody","level":3,"score":0.7362732291221619},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6370018720626831},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6295059323310852},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6074366569519043},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5833642482757568},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5339288711547852},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.4397689700126648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43564194440841675},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4279782176017761},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39078277349472046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38702133297920227},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3391963243484497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24504303932189941},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16111353039741516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08748438954353333}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003301","descriptor_name":"Copper Radioisotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003301","descriptor_name":"Copper Radioisotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003301","descriptor_name":"Copper Radioisotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/c4nr00595c","doi":"https://doi.org/10.1039/c4nr00595c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4nr00595c","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2014/nr/c4nr00595c","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:24777583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24777583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"},{"id":"pmh:oai:digibug.ugr.es:10481/111081","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10481/111081","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1039/c4nr00595c","doi":"https://doi.org/10.1039/c4nr00595c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4nr00595c","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2014/nr/c4nr00595c","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.6700000166893005}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320842","display_name":"Irish Research Council for Science, Engineering and Technology","ror":null},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015137678.pdf","grobid_xml":"https://content.openalex.org/works/W2015137678.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1557061959","https://openalex.org/W1871308790","https://openalex.org/W1966494834","https://openalex.org/W1966542709","https://openalex.org/W1968583232","https://openalex.org/W1976504918","https://openalex.org/W1979020916","https://openalex.org/W1989195046","https://openalex.org/W1990163407","https://openalex.org/W1990443366","https://openalex.org/W1993823385","https://openalex.org/W1995704440","https://openalex.org/W1997787046","https://openalex.org/W1998813476","https://openalex.org/W1999992364","https://openalex.org/W2000469371","https://openalex.org/W2002528172","https://openalex.org/W2005655958","https://openalex.org/W2012915718","https://openalex.org/W2013521422","https://openalex.org/W2015665955","https://openalex.org/W2019922318","https://openalex.org/W2027137358","https://openalex.org/W2035523379","https://openalex.org/W2036271174","https://openalex.org/W2041024369","https://openalex.org/W2041061652","https://openalex.org/W2054981131","https://openalex.org/W2059282715","https://openalex.org/W2063156737","https://openalex.org/W2070003597","https://openalex.org/W2070986221","https://openalex.org/W2072587957","https://openalex.org/W2075882321","https://openalex.org/W2080076901","https://openalex.org/W2081477031","https://openalex.org/W2087898932","https://openalex.org/W2095412415","https://openalex.org/W2098033797","https://openalex.org/W2100090013","https://openalex.org/W2102449174","https://openalex.org/W2102838769","https://openalex.org/W2103229964","https://openalex.org/W2104263066","https://openalex.org/W2108890560","https://openalex.org/W2110634891","https://openalex.org/W2114458369","https://openalex.org/W2119012416","https://openalex.org/W2127083883","https://openalex.org/W2127410754","https://openalex.org/W2127757892","https://openalex.org/W2136633731","https://openalex.org/W2141920788","https://openalex.org/W2144952712","https://openalex.org/W2145688027","https://openalex.org/W2152631611","https://openalex.org/W2154709290","https://openalex.org/W2156354702","https://openalex.org/W2156661377","https://openalex.org/W2157016784","https://openalex.org/W2161946327","https://openalex.org/W2164851891","https://openalex.org/W2166609912","https://openalex.org/W2322857556","https://openalex.org/W2766250687","https://openalex.org/W4211075026"],"related_works":["https://openalex.org/W2138350991","https://openalex.org/W2409285845","https://openalex.org/W2434195791","https://openalex.org/W1566729005","https://openalex.org/W3015376786","https://openalex.org/W1700716001","https://openalex.org/W2054843986","https://openalex.org/W2116210813","https://openalex.org/W2013908504","https://openalex.org/W2440701365"],"abstract_inverted_index":{"For":[0,176],"effective":[1],"localization":[2],"of":[3,31,61,92,108,166,211,216],"functionalized":[4],"nanoparticles":[5],"at":[6,99],"diseased":[7],"tissues":[8],"such":[9,32,181,187],"as":[10,182,188],"solid":[11],"tumours":[12],"or":[13,110],"metastases":[14],"through":[15,43],"biorecognition,":[16],"appropriate":[17],"targeting":[18,59,151,179,184,214],"vectors":[19],"directed":[20],"against":[21],"selected":[22],"tumour":[23],"biomarkers":[24],"are":[25],"a":[26,70,185],"key":[27],"prerequisite.":[28],"The":[29],"diversity":[30],"vector":[33],"molecules":[34],"ranges":[35],"from":[36],"proteins,":[37],"including":[38],"antibodies":[39],"and":[40,45,50,67,69,97,115,121,146],"fragments":[41],"thereof,":[42],"aptamers":[44],"glycans":[46],"to":[47,119,224],"short":[48],"peptides":[49,65],"small":[51,71],"molecules.":[52],"Here,":[53,206],"we":[54,207],"analyse":[55],"the":[56,81,139,209,213],"specific":[57,126],"nanoparticle":[58,168,217],"capabilities":[60],"two":[62],"previously":[63],"suggested":[64],"(D4":[66],"GE11)":[68],"camelid":[72],"single-domain":[73],"antibody":[74],"(sdAb),":[75],"representing":[76],"potential":[77],"recognition":[78,196],"agents":[79],"for":[80,156],"epidermal":[82],"growth":[83],"factor":[84],"receptor":[85,93,186,195],"(EGFR).":[86],"We":[87],"investigate":[88],"specificity":[89,152],"by":[90,104],"way":[91],"RNA":[94],"silencing":[95],"techniques":[96],"look":[98],"increasing":[100,106,157,173],"complexity":[101],"in":[102,124,142,203,219,227],"vitro":[103],"introducing":[105],"concentrations":[107],"human":[109,147,161],"bovine":[111,145],"serum.":[112],"Peptides":[113],"D4":[114],"GE11":[116],"proved":[117],"problematic":[118],"employ":[120],"conjugation":[122],"resulted":[123],"non-receptor":[125],"uptake":[127,169],"into":[128],"cells.":[129],"Our":[130],"results":[131],"show":[132],"that":[133],"sdAb-functionalized":[134],"particles":[135],"can":[136,198],"effectively":[137],"target":[138],"EGFR,":[140],"even":[141],"more":[143,225],"complex":[144,204],"serum":[148,158,162,192],"conditions":[149],"where":[150],"is":[153,170],"largely":[154],"conserved":[155],"concentration.":[159,175],"In":[160],"however,":[163],"an":[164],"inhibition":[165],"overall":[167],"observed":[171],"with":[172,190],"protein":[174],"highly":[177],"affine":[178],"ligands":[180],"sdAbs,":[183],"EGFR":[189],"low":[191],"competitor":[193],"abundance,":[194],"function":[197],"still":[199],"be":[200],"partially":[201],"realised":[202],"conditions.":[205],"stress":[208],"value":[210],"evaluating":[212],"efficiency":[215],"constructs":[218],"realistic":[220],"biological":[221],"milieu,":[222],"prior":[223],"extensive":[226],"vivo":[228],"studies.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}