{"id":"https://openalex.org/W2015128104","doi":"https://doi.org/10.1055/s-0030-1264842","title":"Zebrafish bioassay-guided microfractionation combined with CapNMR a comprehensive approach for the identification of anti-inflammatory and anti-angiogenic constituents of Rhynchosia viscosa","display_name":"Zebrafish bioassay-guided microfractionation combined with CapNMR a comprehensive approach for the identification of anti-inflammatory and anti-angiogenic constituents of Rhynchosia viscosa","publication_year":2010,"publication_date":"2010-08-24","ids":{"openalex":"https://openalex.org/W2015128104","doi":"https://doi.org/10.1055/s-0030-1264842","mag":"2015128104"},"language":"en","primary_location":{"id":"doi:10.1055/s-0030-1264842","doi":"https://doi.org/10.1055/s-0030-1264842","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0030-1264842","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110445929","display_name":"A.D. Crawford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"A Crawford","raw_affiliation_strings":["Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017772278","display_name":"Nadine Bohni","orcid":"https://orcid.org/0000-0001-5188-1256","observed_orcids":["https://orcid.org/0000-0001-5188-1256"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"N Bohni","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, School of Pharmaceutical Sciences, Quai E Ansermet 30, 1211 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, School of Pharmaceutical Sciences, Quai E Ansermet 30, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102755785","display_name":"Jan Maes","orcid":"https://orcid.org/0000-0002-0774-9394","observed_orcids":["https://orcid.org/0000-0002-0774-9394"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J Maes","raw_affiliation_strings":["Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077433476","display_name":"Appolinary A. R. Kamuhabwa","orcid":"https://orcid.org/0000-0001-6895-9187","observed_orcids":["https://orcid.org/0000-0001-6895-9187"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"A Kamuhabwa","raw_affiliation_strings":["Muhimbili University of Health and Allied Sciences, P. O Box, 35091 Dar es Salaam, Tanzania, United Republic Of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muhimbili University of Health and Allied Sciences, P. O Box, 35091 Dar es Salaam, Tanzania, United Republic Of","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064621758","display_name":"Mainen Julius Moshi","orcid":"https://orcid.org/0000-0002-8850-3221","observed_orcids":["https://orcid.org/0000-0002-8850-3221"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"M Moshi","raw_affiliation_strings":["Muhimbili University of Health and Allied Sciences, P. O Box, 35091 Dar es Salaam, Tanzania, United Republic Of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muhimbili University of Health and Allied Sciences, P. O Box, 35091 Dar es Salaam, Tanzania, United Republic Of","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013832811","display_name":"Camila Vicencio Esguerra","orcid":"https://orcid.org/0000-0002-2271-8094","observed_orcids":["https://orcid.org/0000-0002-2271-8094"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C Esguerra","raw_affiliation_strings":["Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010582324","display_name":"Peter A.M. de Witte","orcid":"https://orcid.org/0000-0002-9989-9567","observed_orcids":["https://orcid.org/0000-0002-9989-9567"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P de Witte","raw_affiliation_strings":["Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Genetics Initiative and Laboratory for Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052105510","display_name":"Jean\u2010Luc Wolfender","orcid":"https://orcid.org/0000-0002-0125-952X","observed_orcids":["https://orcid.org/0000-0002-0125-952X"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J Wolfender","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, School of Pharmaceutical Sciences, Quai E Ansermet 30, 1211 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, School of Pharmaceutical Sciences, Quai E Ansermet 30, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3787,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6830202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"76","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.44699999690055847,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.44699999690055847,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.17820000648498535,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.7829999923706055},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukocyte-migration-inhibition","display_name":"leukocyte migration inhibition","score":0.8140000104904175},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.878000020980835},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.6029999852180481},{"id":"https://openalex.org/keywords/natural-product-discovery","display_name":"natural product discovery","score":0.8889999985694885},{"id":"https://openalex.org/keywords/inflammatory-skin-diseases","display_name":"inflammatory skin diseases","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9396699666976929},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.7469461560249329},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6358835697174072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.594199001789093},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5458498597145081},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.48364436626434326},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38842839002609253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3081664443016052},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.14228785037994385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08455806970596313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06838107109069824}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0030-1264842","doi":"https://doi.org/10.1055/s-0030-1264842","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0030-1264842","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2118879229","https://openalex.org/W2063588566","https://openalex.org/W2087140037","https://openalex.org/W2066963158","https://openalex.org/W2017158839","https://openalex.org/W2088039782","https://openalex.org/W2526517703","https://openalex.org/W2519110539","https://openalex.org/W2322682608","https://openalex.org/W2991708230"],"abstract_inverted_index":{"Zebrafish":[0],"have":[1],"recently":[2],"emerged":[3],"as":[4,89],"an":[5,42],"attractive":[6],"i":[7],"n":[8],"vivo":[9],"system":[10],"for":[11,45,79,163,190],"functional":[12],"genomics":[13],"and":[14,27,31,38,61,82,94,170,186,202,217],"drug":[15],"discovery":[16,71],"[1].":[17],"Because":[18],"of":[19,56,76,85,106,109,118,126,136,151,166,179,209,215,224],"their":[20],"small":[21],"size,":[22],"rapid":[23],"development,":[24],"optical":[25],"transparency,":[26],"high":[28],"genetic,":[29],"physiologic,":[30],"pharmacologic":[32],"similarity":[33],"with":[34,148,230],"humans,":[35],"zebrafish":[36,50,147,225],"embryos":[37],"larvae":[39],"are":[40,65],"also":[41,141],"ideal":[43],"model":[44],"natural":[46,69,86,238],"product":[47,70],"discovery.":[48],"As":[49],"bioassays":[51],"require":[52],"only":[53],"microgram":[54],"amounts":[55],"crude":[57,181],"extracts,":[58],"chromatographic":[59],"fractions,":[60],"pure":[62],"compounds,":[63],"we":[64],"developing":[66],"a":[67,212],"zebrafish-based":[68,103],"platform":[72],"that":[73],"takes":[74],"advantage":[75],"modern":[77],"techniques":[78],"the":[80,116,134,164,180,207,222],"isolation":[81],"structural":[83],"elucidation":[84],"products,":[87],"such":[88],"UHPLC-TOF-MS":[90],"profiling,":[91],"LC-MS":[92],"microfractionation":[93],"subsequent":[95],"capillary":[96],"NMR":[97,232],"characterization":[98],"[2].":[99],"An":[100],"in":[101,115,133,145,161,176,192,206,228],"vivo,":[102],"anti-inflammatory":[104],"screen":[105],"methanolic":[107,182],"extracts":[108],"East":[110],"African":[111],"medicinal":[112],"plants":[113],"resulted":[114],"identification":[117,208],"R.":[119,154],"viscosa":[120,155],",":[121],"which":[122],"revealed":[123],"potent":[124],"inhibition":[125],"leukocyte":[127],"migration":[128],"after":[129],"larval":[130],"tail":[131],"transection":[132],"presence":[135],"bacterial":[137],"lipopolysaccharides.":[138],"This":[139],"extract":[140,183],"displayed":[142],"anti-angiogenic":[143],"activity":[144],"transgenic":[146],"vasculature-specific":[149],"expression":[150],"GFP.":[152],"Intriguingly,":[153],"is":[156],"used":[157],"by":[158],"traditional":[159],"healers":[160],"Tanzania":[162],"treatment":[165],"inflammatory":[167],"skin":[168],"disorders":[169],"insect":[171],"bites,":[172],"corroborating":[173],"our":[174],"findings":[175],"zebrafish.":[177,193],"Microfractionation":[178],"was":[184,198],"performed,":[185],"individual":[187],"fractions":[188],"tested":[189],"bioactivity":[191],"One":[194],"highly":[195],"active":[196],"fraction":[197],"subjected":[199],"to":[200,234],"HR-ESI-MS":[201],"CapNMR":[203],"analysis,":[204],"resulting":[205],"genistein":[210],"\u2013":[211],"known":[213],"inhibitor":[214],"inflammation":[216],"angiogenesis.":[218],"These":[219],"results":[220],"indicate":[221],"potential":[223],"bioassay-guided":[226],"microfractionation,":[227],"combination":[229],"sub-milligram":[231],"techniques,":[233],"rapidly":[235],"identify":[236],"bioactive":[237],"products.":[239],"References:":[240],"1.":[241],"Crawford,":[242],"A.":[243],"et":[244,254],"al.":[245,255],"(2008)":[246],"Planta":[247],"Med.,":[248],"6,":[249],"624\u2013632.":[250],"2.":[251],"Glauser,":[252],"G.":[253],"(2009)J.":[256],"Agric.":[257],"Food":[258],"Chem.,":[259],"57,":[260],"1127\u201334.":[261]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
