{"id":"https://openalex.org/W2015127256","doi":"https://doi.org/10.1016/s0955-2863(99)00003-0","title":"Biotin enhances glucose-stimulated insulin secretion in the isolated perfused pancreas of the rat","display_name":"Biotin enhances glucose-stimulated insulin secretion in the isolated perfused pancreas of the rat","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2015127256","doi":"https://doi.org/10.1016/s0955-2863(99)00003-0","mag":"2015127256","pmid":"https://pubmed.ncbi.nlm.nih.gov/15539296"},"language":"en","primary_location":{"id":"doi:10.1016/s0955-2863(99)00003-0","doi":"https://doi.org/10.1016/s0955-2863(99)00003-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0955-2863(99)00003-0","pdf_url":null,"source":{"id":"https://openalex.org/S548917","display_name":"The Journal of Nutritional Biochemistry","issn_l":"0955-2863","issn":["0955-2863","1873-4847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutritional Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102884811","display_name":"Hideyuki Sone","orcid":"https://orcid.org/0000-0002-4574-1772","observed_orcids":["https://orcid.org/0000-0002-4574-1772"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideyuki Sone","raw_affiliation_strings":["Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020275398","display_name":"Michiko Ito","orcid":"https://orcid.org/0000-0001-5593-305X","observed_orcids":["https://orcid.org/0000-0001-5593-305X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiko Ito","raw_affiliation_strings":["Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kimihiko Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimihiko Sugiyama","raw_affiliation_strings":["Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019556201","display_name":"Makoto Ohneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Ohneda","raw_affiliation_strings":["The Second Department of Internal Medicine, School of Medicine, Tohoku University, Aoba-ku, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, School of Medicine, Tohoku University, Aoba-ku, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110109007","display_name":"Masaru Maebashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Maebashi","raw_affiliation_strings":["The Second Department of Internal Medicine, School of Medicine, Tohoku University, Aoba-ku, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, School of Medicine, Tohoku University, Aoba-ku, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036740463","display_name":"Yuji Furukawa","orcid":"https://orcid.org/0000-0002-3722-293X","observed_orcids":["https://orcid.org/0000-0002-3722-293X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Furukawa","raw_affiliation_strings":["Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102884811"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.4078,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.58379707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"10","issue":"4","first_page":"237","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biotin","display_name":"biotin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9639999866485596},{"id":"https://openalex.org/keywords/biotin-deficiency","display_name":"biotin deficiency","score":0.9110000133514404},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.5899999737739563},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.5350000262260437},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.8814880847930908},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.854521632194519},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8319252729415894},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.818002462387085},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6452068090438843},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5659002065658569},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4337097406387329},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3784683048725128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22520571947097778},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20679029822349548},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.13346615433692932}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/s0955-2863(99)00003-0","doi":"https://doi.org/10.1016/s0955-2863(99)00003-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0955-2863(99)00003-0","pdf_url":null,"source":{"id":"https://openalex.org/S548917","display_name":"The Journal of Nutritional Biochemistry","issn_l":"0955-2863","issn":["0955-2863","1873-4847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutritional Biochemistry","raw_type":"journal-article"},{"id":"pmid:15539296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15539296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of nutritional biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W40321310","https://openalex.org/W339813795","https://openalex.org/W1520184516","https://openalex.org/W1564656332","https://openalex.org/W1759896623","https://openalex.org/W1966878918","https://openalex.org/W1975599578","https://openalex.org/W1984304216","https://openalex.org/W1984541901","https://openalex.org/W1985770721","https://openalex.org/W1992478978","https://openalex.org/W1994115989","https://openalex.org/W1996701347","https://openalex.org/W1997849672","https://openalex.org/W2003859301","https://openalex.org/W2003992400","https://openalex.org/W2028994036","https://openalex.org/W2035078216","https://openalex.org/W2036232265","https://openalex.org/W2040593177","https://openalex.org/W2041203733","https://openalex.org/W2042851717","https://openalex.org/W2047665588","https://openalex.org/W2052054828","https://openalex.org/W2052361056","https://openalex.org/W2052688835","https://openalex.org/W2053544705","https://openalex.org/W2054168560","https://openalex.org/W2057458993","https://openalex.org/W2057509558","https://openalex.org/W2065249636","https://openalex.org/W2066108840","https://openalex.org/W2070092454","https://openalex.org/W2074546186","https://openalex.org/W2077020215","https://openalex.org/W2091528336","https://openalex.org/W2110234792","https://openalex.org/W2116828634","https://openalex.org/W2117267087","https://openalex.org/W2122258473","https://openalex.org/W2131540338","https://openalex.org/W2135221670","https://openalex.org/W2140143708","https://openalex.org/W2153605535","https://openalex.org/W2162898930","https://openalex.org/W2170289608","https://openalex.org/W2218148748","https://openalex.org/W2323400995","https://openalex.org/W4211027922"],"related_works":["https://openalex.org/W2077020215","https://openalex.org/W2411891527","https://openalex.org/W1975599578","https://openalex.org/W2022325261","https://openalex.org/W2020672168","https://openalex.org/W2284656999","https://openalex.org/W2063987154","https://openalex.org/W2034752576","https://openalex.org/W2171844824","https://openalex.org/W2355862128"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}