{"id":"https://openalex.org/W2015075645","doi":"https://doi.org/10.1016/j.ijd.2012.12.006","title":"Laboratory evaluation of the antibacterial and cytotoxic effect of alpha-mangostin when used as a root canal irrigant","display_name":"Laboratory evaluation of the antibacterial and cytotoxic effect of alpha-mangostin when used as a root canal irrigant","publication_year":2013,"publication_date":"2013-01-08","ids":{"openalex":"https://openalex.org/W2015075645","doi":"https://doi.org/10.1016/j.ijd.2012.12.006","mag":"2015075645"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijd.2012.12.006","doi":"https://doi.org/10.1016/j.ijd.2012.12.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijd.2012.12.006","pdf_url":null,"source":{"id":"https://openalex.org/S2764628807","display_name":"Indian Journal of Dentistry","issn_l":"0975-962X","issn":["0975-962X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Dentistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073702015","display_name":"Ruchadaporn Kaomongkolgit","orcid":"https://orcid.org/0000-0003-2055-6412","observed_orcids":["https://orcid.org/0000-0003-2055-6412"]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Ruchadaporn Kaomongkolgit","raw_affiliation_strings":["Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055188547","display_name":"Kusuma Jamdee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kusuma Jamdee","raw_affiliation_strings":["Dental Science Research Center, Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dental Science Research Center, Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064909036","display_name":"Jittima Pumklin","orcid":"https://orcid.org/0000-0002-2152-7245","observed_orcids":["https://orcid.org/0000-0002-2152-7245"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Jittima Pumklin","raw_affiliation_strings":["Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053148496","display_name":"Prasit Pavasant","orcid":"https://orcid.org/0000-0002-8909-5928","observed_orcids":["https://orcid.org/0000-0002-8909-5928"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Prasit Pavasant","raw_affiliation_strings":["Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073702015"],"corresponding_institution_ids":["https://openalex.org/I66200439"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"12","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-mangostin","display_name":"\u03b1-mangostin","score":1.0},{"id":"https://openalex.org/keywords/root-canal-irrigants","display_name":"root canal irrigants","score":0.8069999814033508},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.984000027179718},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/periodontal-ligament-cells","display_name":"periodontal ligament cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sodium-hypochlorite","display_name":"sodium hypochlorite","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chlorhexidine","display_name":"chlorhexidine","score":1.0},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7720000147819519},{"id":"https://openalex.org/keywords/minimum-bactericidal-concentration","display_name":"minimum bactericidal concentration","score":0.9369999766349792},{"id":"https://openalex.org/keywords/time-kill-kinetics","display_name":"time-kill kinetics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mangosteen-pericarp-extract","display_name":"mangosteen pericarp extract","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.9314050078392029},{"id":"https://openalex.org/C2776776456","wikidata":"https://www.wikidata.org/wiki/Q407204","display_name":"Sodium hypochlorite","level":2,"score":0.733992338180542},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.663720428943634},{"id":"https://openalex.org/C26381139","wikidata":"https://www.wikidata.org/wiki/Q1158816","display_name":"Minimum bactericidal concentration","level":4,"score":0.6111780405044556},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6064181327819824},{"id":"https://openalex.org/C2777084678","wikidata":"https://www.wikidata.org/wiki/Q15646788","display_name":"Chlorhexidine","level":2,"score":0.5922749042510986},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5251840353012085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5026447772979736},{"id":"https://openalex.org/C2779747767","wikidata":"https://www.wikidata.org/wiki/Q848390","display_name":"Root canal","level":2,"score":0.4578835070133209},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.45328572392463684},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4353078603744507},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.40029600262641907},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3698005676269531},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2674291133880615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24850603938102722},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2395746409893036},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19712895154953003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17345687747001648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1400792896747589},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.10240346193313599},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ijd.2012.12.006","doi":"https://doi.org/10.1016/j.ijd.2012.12.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijd.2012.12.006","pdf_url":null,"source":{"id":"https://openalex.org/S2764628807","display_name":"Indian Journal of Dentistry","issn_l":"0975-962X","issn":["0975-962X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Dentistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W170265524","https://openalex.org/W1513526247","https://openalex.org/W1965051826","https://openalex.org/W1965055857","https://openalex.org/W1965705884","https://openalex.org/W1985308595","https://openalex.org/W1993319393","https://openalex.org/W1994075173","https://openalex.org/W1997025327","https://openalex.org/W2005839814","https://openalex.org/W2008757158","https://openalex.org/W2012596498","https://openalex.org/W2016763331","https://openalex.org/W2017127543","https://openalex.org/W2026334403","https://openalex.org/W2028808955","https://openalex.org/W2028982335","https://openalex.org/W2039207467","https://openalex.org/W2116907180","https://openalex.org/W2125824313","https://openalex.org/W2126814949","https://openalex.org/W2127582739","https://openalex.org/W2128021836","https://openalex.org/W2137591193","https://openalex.org/W2149273076","https://openalex.org/W2155837747","https://openalex.org/W2158036849","https://openalex.org/W2165674962","https://openalex.org/W2463234347"],"related_works":["https://openalex.org/W2896031577","https://openalex.org/W2008757158","https://openalex.org/W2908962168","https://openalex.org/W7062621131","https://openalex.org/W2889826566","https://openalex.org/W2087785003","https://openalex.org/W4324319753","https://openalex.org/W2726243303","https://openalex.org/W4388195308","https://openalex.org/W7124146681"],"abstract_inverted_index":{"The":[0,53,71,115],"aim":[1],"of":[2,14,47,56,73,90,120,126,168,182],"this":[3],"study":[4],"was":[5,42,61,76,84,93,122,144,171],"to":[6,17,31,86,202,211],"investigate":[7],"the":[8,45,88,98,104,140,149,153,160,174,183],"antibacterial":[9,194],"activity":[10,20,75,119,195],"against":[11,95,196],"Enterococcus":[12],"faecalis":[13,60,117,198],"alpha-mangostin":[15,57,121,191],"and":[16,25,65,103,111,132,152,177,199],"compare":[18],"its":[19,33,209],"with":[21],"sodium":[22],"hypochlorite":[23],"(NaOCl)":[24],"chlorhexidine":[26],"(CHX)":[27],"as":[28,30,214],"well":[29],"assess":[32,87],"biocompatibility":[34],"using":[35],"human":[36,203],"periodontal":[37],"ligament":[38],"(PDL)":[39],"cell.":[40],"Alpha-mangostin":[41,92],"extracted":[43],"from":[44],"pericarps":[46],"mangosteen":[48],"by":[49,63,78],"thin":[50],"layer":[51],"chromatography.":[52],"inhibitory":[54,100],"effect":[55],"on":[58],"E.":[59,96,116,197],"determined":[62],"cultures":[64],"an":[66],"applied":[67],"broth":[68],"dilution":[69],"test.":[70],"rate":[72],"bactericidal":[74,106],"evaluated":[77],"time-kill.":[79],"Human":[80],"PDL":[81,204],"cell":[82,169],"culture":[83],"used":[85,213],"cytotoxicity":[89,161],"alpha-mangostin.":[91],"effective":[94],"faecalis,":[97],"minimum":[99,105],"concentration":[101,107],"(MIC)":[102],"(MBC)":[108],"were":[109],"1.97":[110],"3.94":[112],"\u03bcg/ml,":[113],"respectively.":[114,136],"killing":[118],"higher":[123],"than":[124],"that":[125,164,190],"CHX":[127],"at":[128,139],"2":[129],"\u00d7":[130,134],"MBC":[131],"4":[133],"MBC,":[135],"When":[137],"compared":[138],"same":[141],"concentration,":[142],"there":[143],"no":[145,165],"significant":[146,166],"difference":[147,167],"between":[148,173],"alpha-mangostin-treated":[150,175],"group":[151,155,176,179],"NaOCl-treated":[154],"(P":[156],"<":[157],"0.05).":[158],"From":[159],"test":[162],"demonstrated":[163],"viability":[170],"observed":[172],"control":[178],"in":[180,206],"all":[181],"treatment":[184],"time":[185],"intervals.":[186],"These":[187],"findings":[188],"indicated":[189],"showed":[192],"promising":[193],"low":[200],"toxicity":[201],"cells":[205],"vitro,":[207],"suggesting":[208],"potential":[210],"be":[212],"a":[215],"root":[216],"canal":[217],"irrigant.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}