{"id":"https://openalex.org/W2015075423","doi":"https://doi.org/10.3892/ijmm.2.4.477","title":"Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine.","display_name":"Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine.","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2015075423","doi":"https://doi.org/10.3892/ijmm.2.4.477","mag":"2015075423","pmid":"https://pubmed.ncbi.nlm.nih.gov/9857238"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.2.4.477","doi":"https://doi.org/10.3892/ijmm.2.4.477","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.2.4.477","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Sumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Sumi","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027059300","display_name":"Kiyoshi Kidouchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kidouchi","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024798533","display_name":"Makiko Kondou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Kondou","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Hayashi","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Dobashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Dobashi","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089802472","display_name":"Masanori Kouwaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Kouwaki","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057783901","display_name":"Hajime Togari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Togari","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091812588","display_name":"Yoshiro Wada","orcid":"https://orcid.org/0000-0001-9394-9888","observed_orcids":["https://orcid.org/0000-0001-9394-9888"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Wada","raw_affiliation_strings":["Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":null,"apc_paid":null,"fwci":0.2306,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.46596215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"4","first_page":"477","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.12770000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dihydropyrimidine-dehydrogenase-deficiency","display_name":"dihydropyrimidine dehydrogenase deficiency","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pyrimidine-metabolism","display_name":"pyrimidine metabolism","score":0.7250000238418579},{"id":"https://openalex.org/keywords/adverse-drug-reaction-prediction","display_name":"adverse drug reaction prediction","score":0.8050000071525574},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.921999990940094},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dihydrouracil","display_name":"dihydrouracil","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2778050828","wikidata":"https://www.wikidata.org/wiki/Q1114455","display_name":"Dihydropyrimidine dehydrogenase","level":5,"score":0.7847707271575928},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.780524492263794},{"id":"https://openalex.org/C2779554091","wikidata":"https://www.wikidata.org/wiki/Q182990","display_name":"Uracil","level":3,"score":0.6193972826004028},{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.5793451070785522},{"id":"https://openalex.org/C200159599","wikidata":"https://www.wikidata.org/wiki/Q4893563","display_name":"Pyrimidine metabolism","level":4,"score":0.5183585286140442},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5035449862480164},{"id":"https://openalex.org/C2778143274","wikidata":"https://www.wikidata.org/wiki/Q1626599","display_name":"Reference range","level":2,"score":0.50262451171875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.488312691450119},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.46719953417778015},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4359990954399109},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.42755240201950073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41394418478012085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27828556299209595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2736697494983673},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22046193480491638},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.19827163219451904},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16014179587364197},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15758651494979858},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.07980754971504211},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.07240122556686401},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011686","descriptor_name":"Purine-Pyrimidine Metabolism, Inborn Errors","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011686","descriptor_name":"Purine-Pyrimidine Metabolism, Inborn Errors","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D054067","descriptor_name":"Dihydropyrimidine Dehydrogenase Deficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.2.4.477","doi":"https://doi.org/10.3892/ijmm.2.4.477","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.2.4.477","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:9857238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9857238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310756","display_name":"Japan Research Foundation for Clinical Pharmacology","ror":"https://ror.org/02900by63"},{"id":"https://openalex.org/F4320325453","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113414095","https://openalex.org/W1992274500","https://openalex.org/W4409118769","https://openalex.org/W4283257613","https://openalex.org/W2619919007","https://openalex.org/W2785266975","https://openalex.org/W1977980459","https://openalex.org/W1974140956","https://openalex.org/W7096171902","https://openalex.org/W2056086147"],"abstract_inverted_index":{"Dihydropyrimidine":[0],"dehydrogenase":[1],"(DPD)":[2],"deficiency":[3,30,64,159,168],"with":[4,106],"a":[5,157,162],"defect":[6],"of":[7,17,62,117,124,139,146,173,179,188,202,208],"the":[8,15,22,166,170,180,189,193,209],"pyrimidine":[9,42],"catabolic":[10],"pathway":[11],"has":[12],"recently":[13],"become":[14],"focus":[16],"considerable":[18],"attention,":[19],"due":[20],"to":[21,77,94,113,135,152],"severe":[23],"5-fluorouracil":[24],"(5-FU)":[25],"toxicities":[26,37],"occurring":[27],"in":[28,40,73,98,186],"DPD":[29,63,158,167],"patients.":[31],"Studies":[32],"also":[33],"suggest":[34],"that":[35,50],"5-FU":[36],"could":[38],"occur":[39],"another":[41],"metabolic":[43],"disorder,":[44],"dihydropyrimidinuria":[45],"(DHPuria).":[46],"This":[47],"study":[48,154],"shows":[49],"urinary":[51,69],"dihydrothymine":[52],"(DHT)":[53],"and":[54,65,71,83,89,121,143,161,204],"thymine":[55],"(THY)":[56],"are":[57],"useful":[58],"indexes":[59],"for":[60,109,119,126,131,141,148],"detection":[61],"DHPuria.":[66],"We":[67],"measured":[68],"DHT":[70,88,120,142,203],"THY":[72,90,171],"276":[74],"Japanese":[75],"adults":[76],"establish":[78],"reference":[79,101,129,181],"ranges.":[80],"When":[81],"males":[82,110],"females":[84,132],"were":[85,92,111,133,177,191],"compared,":[86],"both":[87,206],"levels":[91,185],"found":[93,112,134],"be":[95,114,136],"significantly":[96],"higher":[97],"females.":[99],"The":[100,128,196],"ranges":[102,130],"(mean":[103],"+/-":[104],"SD":[105],"logarithmic":[107],"values)":[108],"1.56-5.70":[115],"micromol/g":[116,123,138,145],"creatinine":[118,125,140,147],"0.40-1.47":[122],"THY.":[127,149],"1.89-8.33":[137],"0.58-2.30":[144],"In":[150,165],"addition":[151],"this":[153],"we":[155],"analyzed":[156],"case":[160,198],"DHPuria":[163,197],"case.":[164],"case,":[169],"concentrations":[172],"all":[174],"urine":[175],"samples":[176,190],"out":[178,207],"range.":[182,195,211],"However,":[183],"uracil":[184],"most":[187],"within":[192],"normal":[194,210],"excreted":[199],"large":[200],"amounts":[201],"dihydrouracil,":[205]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}