{"id":"https://openalex.org/W2015069286","doi":"https://doi.org/10.1099/0022-1317-62-2-271","title":"Molecular Epidemiology of Tick-borne Encephalitis Virus: Peptide Mapping of Large Non-structural Proteins of European Isolates and Comparison with Other Flaviviruses","display_name":"Molecular Epidemiology of Tick-borne Encephalitis Virus: Peptide Mapping of Large Non-structural Proteins of European Isolates and Comparison with Other Flaviviruses","publication_year":1982,"publication_date":"1982-10-01","ids":{"openalex":"https://openalex.org/W2015069286","doi":"https://doi.org/10.1099/0022-1317-62-2-271","mag":"2015069286","pmid":"https://pubmed.ncbi.nlm.nih.gov/6292351"},"language":"en","primary_location":{"id":"doi:10.1099/0022-1317-62-2-271","doi":"https://doi.org/10.1099/0022-1317-62-2-271","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-62-2-271","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110095607","display_name":"Franz-Xaver Heinz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F. X. Heinz","raw_affiliation_strings":["Institute of Virology, University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101910467","display_name":"Christophe Kunz","orcid":"https://orcid.org/0000-0002-0511-3915","observed_orcids":["https://orcid.org/0000-0002-0511-3915"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C. Kunz","raw_affiliation_strings":["Institute of Virology, University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":null,"apc_paid":null,"fwci":4.4554,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93647404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"2","first_page":"271","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.14100000262260437,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tick-borne-encephalitis-virus","display_name":"tick-borne encephalitis virus","score":1.0},{"id":"https://openalex.org/keywords/nonstructural-proteins","display_name":"non-structural proteins","score":0.8240000009536743},{"id":"https://openalex.org/keywords/peptide-mapping","display_name":"peptide mapping","score":0.7009999752044678},{"id":"https://openalex.org/keywords/flavivirus","display_name":"flavivirus","score":0.36000001430511475},{"id":"https://openalex.org/keywords/west-nile-virus","display_name":"West Nile virus","score":0.8970000147819519},{"id":"https://openalex.org/keywords/murray-valley-encephalitis-virus","display_name":"Murray Valley encephalitis virus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/louping-ill-virus","display_name":"louping ill virus","score":0.9649999737739563},{"id":"https://openalex.org/keywords/far-eastern-subtype","display_name":"Far Eastern subtype","score":0.7760000228881836},{"id":"https://openalex.org/keywords/protein-heterogeneity","display_name":"protein heterogeneity","score":0.5210000276565552},{"id":"https://openalex.org/keywords/serological-cross-reactivity","display_name":"serological cross-reactivity","score":0.48500001430511475},{"id":"https://openalex.org/keywords/limited-proteolysis","display_name":"limited proteolysis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/molecular-epidemiology","display_name":"molecular epidemiology","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8753150701522827},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8082578182220459},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7435134649276733},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.6486949920654297},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.627628743648529},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6100830435752869},{"id":"https://openalex.org/C2776281056","wikidata":"https://www.wikidata.org/wiki/Q251824","display_name":"Tick-borne encephalitis virus","level":4,"score":0.4968302547931671},{"id":"https://openalex.org/C2779141303","wikidata":"https://www.wikidata.org/wiki/Q738292","display_name":"Japanese encephalitis","level":4,"score":0.4466962218284607},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.21206146478652954}],"mesh":[{"descriptor_ui":"D004669","descriptor_name":"Encephalitis Viruses, Tick-Borne","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005416","descriptor_name":"Flavivirus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1099/0022-1317-62-2-271","doi":"https://doi.org/10.1099/0022-1317-62-2-271","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-62-2-271","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:6292351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6292351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2151249029","https://openalex.org/W2085633705","https://openalex.org/W2040407633","https://openalex.org/W2416820683","https://openalex.org/W2098522883","https://openalex.org/W8508461","https://openalex.org/W1995884754","https://openalex.org/W2023798372","https://openalex.org/W2038264026","https://openalex.org/W2471776615"],"abstract_inverted_index":{"Nine":[0],"virus-specified":[1,236],"proteins":[2,26,63,237],"were":[3,27,109,290],"identified":[4],"by":[5,20,192],"SDS-polyacrylamide":[6],"gel":[7],"electrophoresis":[8],"in":[9,194,204,239,262],"[35S]methionine-labelled":[10],"chick":[11],"embryo":[12],"cells":[13,69,240],"infected":[14,241],"with":[15,22,87,126,162,242,306],"tick-borne":[16],"encephalitis":[17,228],"(TBE)":[18],"virus":[19,67,101,141,176,182,229,270],"comparison":[21],"mock-infected":[23],"cells.":[24],"These":[25,292],"designated":[28],"P91,":[29,47],"p74,":[30],"p72,":[31],"P67,":[32,48],"GP53(E),":[33],"P47,":[34],"p25,":[35],"P15(C)":[36],"and":[37,50,75,107,116,128,177,225,276],"P14.5":[38],"according":[39],"to":[40,89,143,219,258,271,303],"their":[41,199],"molecular":[42],"weights.":[43],"Peptide":[44,111],"mapping":[45,112],"of":[46,60,80,92,99,113,149,159,174,198,206,235,282,288],"GP53(E)":[49],"P47":[51],"from":[52,64,102,119,188,265],"TBE":[53,100,140,175,269],"virus-infected":[54],"cells,":[55],"as":[56,58,284,286],"well":[57,285],"those":[59,205,287],"the":[61,78,90,150,157,163,167,170,178,189,195,207,220,232,251,279,307],"corresponding":[62],"West":[65],"Nile":[66],"(WNV)-infected":[68],"(previously":[70],"termed":[71],"NV5,":[72,210,255,283],"NV4,":[73,289],"V3":[74],"NV3),":[76],"demonstrated":[77],"uniqueness":[79],"these":[81,121],"proteins.":[82],"Almost":[83],"no":[84],"subtype":[85,173,191,212],"variability,":[86],"respect":[88],"pattern":[91],"intracellular":[93],"proteins,":[94,293],"was":[95,154],"found":[96,161,238],"when":[97],"isolates":[98,122],"Austria,":[103],"Switzerland,":[104],"Germany,":[105],"Finland":[106],"Czechoslovakia":[108],"compared.":[110],"NV5":[114],"(P91)":[115],"NV4":[117],"(P67)":[118],"all":[120],"using":[123],"limited":[124],"proteolysis":[125],"alpha-chymotrypsin":[127],"V8":[129],"protease":[130],"revealed":[131,231,295],"completely":[132],"identical":[133],"patterns,":[134],"thus":[135],"extending":[136],"our":[137],"observations":[138],"that":[139,249,277,304],"seems":[142],"represent":[144],"a":[145,296],"very":[146],"stable":[147],"member":[148],"flavivirus":[151],"genus,":[152],"which":[153],"based":[155],"on":[156],"lack":[158],"variation":[160],"structural":[164,200,308],"glycoprotein.":[165,223,309],"On":[166],"other":[168],"hand,":[169],"Far":[171],"Eastern":[172],"closely":[179],"related":[180],"louping-ill":[181],"could":[183],"not":[184,217],"only":[185],"be":[186],"differentiated":[187],"Western":[190],"differences":[193],"peptide":[196,280],"maps":[197,281],"glycoprotein":[201],"but":[202],"also":[203,250,278],"non-structural":[208,253],"protein":[209],"i.e.":[211],"or":[213],"subgroup":[214],"variations":[215],"are":[216],"confined":[218],"virion":[221],"surface":[222],"WNV":[224],"Murray":[226],"Valley":[227],"(MVEV)":[230],"expected":[233],"heterogeneity":[234],"different":[243],"flaviviruses.":[244],"It":[245],"is":[246,256],"especially":[247],"interesting":[248],"largest":[252],"protein,":[254],"subject":[257],"this":[259],"heterogeneity,":[260],"ranging":[261],"mol.":[263],"wt.":[264],"91":[266],"000":[267,273],"for":[268,274],"98":[272],"MVEV":[275],"unrelated.":[291],"therefore,":[294],"variability":[297],"between":[298],"serologically":[299],"distinct":[300],"flaviviruses":[301],"similar":[302],"observed":[305]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}